Papers and Patents

1. JENNIFER M. SEALY
e-mail: jennifermsealy@gmail.com
PUBLICATIONS
PAPERS
Simeon Bowers, Anh P. Truong, R. Jeffrey Neitz, Roy K. Hom, Jennifer M. Sealy, Gary D. Probst,
David Quincy, Brian Peterson, Wayman Chan, Robert A. Galemmo Jr., Andrei W. Konradi, Hing L.
Sham, Gergley Tóth, Hu Pan, May Lin, Nanhua Yao, Dean R. Artis, Heather Zhang, Linda Chen, Mark
Dryer, Bhushan Samant, Wes Zmolek, Karina Wong, Colin Lorentzen, Erich Goldbach, George Tonn,
Kevin P. Quinn, John-Michael Sauer, Sarah Wright, Kyle Powell, Lany Ruslim, Zhao Ren, Frédérique
Bard, Ted A. Yednock, Irene Griswold-Prenner. Design and synthesis of brain penetrant selective JNK
inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.
Bioorganic & Medicinal Chemistry Letters, (2011), 21(18), 5521-5527.
Probst, Gary D.; Bowers, Simeon; Sealy, Jennifer M.; Truong, Anh P.; Hom, Roy K.; Galemmo, Robert
A., Jr.; Konradi, Andrei W.; Sham, Hing L.; Quincy, David A.; Pan, Hu; Yao, Nanhua; Lin, May; Toth,
Gergley; Artis, Dean R.; Zmolek, Wes; Wong, Karina; Qin, Ann; Lorentzen, Colin; Nakamura, David F.;
Quinn, Kevin P.; Sauer, John-Michael; Powell, Kyle; Ruslim, Lany; Wright, Sarah; Chereau, David;
Ren, Zhao; Anderson, John P.; Bard, Frederique; Yednock, Ted A.; Griswold-Prenner, Irene. Highly
selective c-Jun N-terminal kinase (JNK)2 and 3 inhibitors with in vitro CNS-like pharmacokintetic
properties prevent neurodegeneration. Bioorganic & Medicinal Chemistry Letters, (2011), 21(1),
315-319.
Hom, Roy K.; Bowers, Simeon; Sealy, Jennifer M.; Truong, Anh P.; Probst, Gary D.; Neitzel, Martin
L.; Neitz, R. Jeffrey; Fang, Larry; Brogley, Louis; Wu, Jing; Konradi, Andrei W.; Sham, Hing L.; Toth,
Gergely; Pan, Hu; Yao, Nanhua; Artis, Dean R.; Quinn, Kevin; Sauer, John-Michael; Powell, Kyle; Ren,
Zhao; Bard, Frederique; Yednock, Ted A.; Griswold-Prenner, Irene. Design and synthesis of
disubstituted thiophene and thiazole based inhibitors of JNK. Bioorganic & Medicinal Chemistry
Letters, (2010), 20(24), 7303-7307.
Truong, Anh P.; Toth, Gergley; Probst, Gary D.; Sealy, Jennifer M.; Bowers, Simeon; Wone, David W.
G.; Dressen, Darren; Hom, Roy K.; Konradi, Andrei W.; Sham, Hing L.; Wu, Jing; Peterson, Brian T.;
Ruslim, Lany; Bova, Michael P.; Kholodenko, Dora; Motter, Ruth N.; Bard, Frederique; Santiago,
Pamela; Ni, Huifang; Chian, David; Soriano, Ferdie; Cole, Tracy; Brigham, Elizabeth F.; Wong, Karina;
Zmolek, Wes; Goldbach, Erich; Samant, Bhushan; Chen, Linda; Zhang, Hongbing; Nakamura, David F.;
Quinn, Kevin P.; Yednock, Ted A.; Sauer, John-Michael. Design of an orally efficacious
hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model. Bioorganic &
Medicinal Chemistry Letters, (2010), 20(21), 6231-6236.
Probst, Gary D.; Bowers, Simeon; Sealy, Jennifer M.; Stupi, Brian; Dressen, Darren; Jagodzinska,
Barbara M.; Aquino, Jose; Gailunas, Andrea; Truong, Anh P.; Tso, Luke; Xu, Ying-Zi; Hom, Roy K.;
John, Varghese; Tung, Jay S.; Pleiss, Michael A.; Tucker, John A.; Konradi, Andrei W.; Sham, Hing L.;
Jagodzinski, Jacek; Toth, Gergely; Brecht, Eric; Yao, Nanhua; Pan, Hu; Lin, May; Artis, Dean R.;
Ruslim, Lany; Bova, Michael P.; Sinha, Sukanto; Yednock, Ted A.; Gauby, Shawn; Zmolek, Wes;
Quinn, Kevin P.; Sauer, John-Michael. Design and synthesis of hydroxyethylamine (HEA) BACE-1
inhibitors: Structure-activity relationship of the aryl region. Bioorganic & Medicinal Chemistry
Letters, (2010), 20(20), 6034-6039.
Truong, Anh P.; Probst, Gary D.; Aquino, Jose; Fang, Larry; Brogley, Louis; Sealy, Jennifer M.; Hom,
Roy K.; Tucker, John A.; John, Varghese; Tung, Jay S.; Pleiss, Michael A.; Konradi, Andrei W.; Sham,
Hing L.; Dappen, Michael S.; Toth, Gergley; Yao, Nanhua; Brecht, Eric; Pan, Hu; Artis, Dean R.;

2. Ruslim, Lany; Bova, Michael P.; Sinha, Sukanto; Yednock, Ted A.; Zmolek, Wes; Quinn, Kevin P.;
Sauer, John-Michael. Improving the permeability of the hydroxyethylamine BACE-1 inhibitors:
Structure-activity relationship of P2' substituents. Bioorganic & Medicinal Chemistry Letters, (2010),
20(16), 4789-4794.
Sealy, Jennifer M.; Truong, Anh P.; Tso, Luke; Probst, Gary D.; Aquino, Jose; Hom, Roy K.;
Jagodzinska, Barbara M.; Dressen, Darren; Wone, David W. G.; Brogley, Louis; John, Varghese; Tung,
Jay S.; Pleiss, Michael A.; Tucker, John A.; Konradi, Andrei W.; Dappen, Michael S.; Toth, Gergely;
Pan, Hu; Ruslim, Lany; Miller, Jim; Bova, Michael P.; Sinha, Sukanto; Quinn, Kevin P.; Sauer, John-
Michael. Design and synthesis of cell potent BACE-1 inhibitors: Structure-activity relationship of P
1' substituents. Bioorganic & Medicinal Chemistry Letters, (2009), 19(22), 6386-6391.
Eichler, E.; Yan, F.; Sealy, J.; Whitfield, D. M. 1-Methyl 1'-cyclopropylmethyl: an acid labile O-
protecting group for polymer-supported oligosaccharide synthesis. Tetrahedron, (2001), 57(31),
6679-6693.
Miller, Rebecca S.; Sealy, Jennifer M.; Shabangi, Masangu; Kuhlman, Matthew L.; Fuchs, James R.;
Flowers, Robert A., II. Reactions of SmI2 with Alkyl Halides and Ketones: Inner-Sphere vs Outer-
Sphere Electron Transfer in Reactions of Sm(II) Reductants. Journal of the American Chemical
Society, (2000), 122(32), 7718-7722.
Flowers, Robert A., II; Caracoti, Andrei; Fuchs, James R.; Sealy, Jennifer; Shabangi, Masangu. The
influence of cosolvent and additives on the reactivity of samarium diiodide. Recent Research
Developments in Organic Chemistry, (1999), 3(Pt. 1), 141-149.
Shotwell, J. Brad; Sealy, Jennifer M.; Flowers, Robert A. II. Structure and energetics of the
samarium diiodide-HMPA complex in tetrahydrofuran. Journal of Organic Chemistry, (1999),
64(14), 5251-5255.
Shabangi, Masangu; Sealy, Jennifer M.; Fuchs, James R.; Flowers, Robert A., II. The effect of
cosolvent on the reducing power of SmI2 in tetrahydrofuran. Tetrahedron Letters, (1998), 39(25),
4429-4432.
PATENTS
Galemmo, Robert A., Jr.; Artis, Dean Richard; Ye, Xiaocong Michael; Aubele, Danielle L.; Truong, Anh
P.; Bowers, Simeon; Hom, Roy K.; Zhu, Yong-Liang; Neitz, R. Jeffrey; Sealy, Jennifer; Adler, Marc;
Beroza, Paul; Anderson, John P. Preparation of pteridinones as polo-like kinase inhibitors for
treating neurodegenerative diseases and cancers. PCT Int. Appl. (2011), 439pp. WO 2011079118.
Sham, Hing L.; Konradi, Andrei W.; Hom, Roy K.; Probst, Gary D.; Bowers, Simeon; Truong, Anh;
Neitz, R. Jeffrey; Sealy, Jennifer; Toth, Gergely. Preparation of N-(thiophen-3-yl)acetamide
derivatives as inhibitors of JNK N-terminal kinase. PCT Int. Appl. (2010), 269pp. WO 2010091310
Sealy, Jennifer; Hom, Roy; John, Varghese; Probst, Gary; Tung, Jay S. Preparation of oxime-
containing N-(3-amino-1-arylmethyl-2-hydroxypropyl) carboxamide and related selective β
-secretase inhibitors for treating amyloidosis. PCT Int. Appl. (2006), 225 pp. WO 2006010094
John, Varghese; Hom, Roy; Sealy, Jennifer; Tucker, John. Methods of treatment of amyloidosis using
bi-aryl aspartyl protease inhibitors. U.S. Pat. Appl. Publ. (2006), 86 pp. US 2006014737
John, Varghese; Hom, Roy; Sealy, Jennifer; Aquino, Jose; Probst, Gary; Tung, Jay; Fang, Larry.
Preparation of N-(3-amino-2-hydroxypropyl)acetamides as aspartyl protease and beta secretase
inhibitors for treating conditions associated with amyloidosis such as Alzheimer's disease. PCT Int.
Appl. (2005), 499 pp. WO 2005070407

3. Tung, Jay; Latimer, Lee; Wu, Jing; Garofalo, Albert; Pleiss, Michael; Dressen, Darren; Guinn, Ashley;
Jenkins, Scott; Sealy, Jennifer; Tucker, John; Wone, David. Acylated amino acid amidyl pyrazoles
and related compounds. PCT Int. (2005), 96pp. WO 2005009344
Varghese, John; Maillard, Michel; Jagodzinska, Barbara; Beck, James P.; Gailunas, Andrea; Fang, Larry;
Sealy, Jennifer; Tenbrink, Ruth; Freskos, John; Mickelson, John; Samala, Lakshman; Hom, Roy.
Preparation of N,N'-substituted-1,3-diamino-2-hydroxypropanes for treating Alzheimer's disease.
PCT Int. Appl. (2003), 1243 pp. WO 2003040096