The first commandment serves as the foundation for the other commandments, emphasizing the need for worship and adoration of the one true God. It fosters key virtues such as faith, prayer, sacrifice, and charity, while condemning practices like idolatry and divination that deviate from true religious devotion. Violations of this commandment include irreligion, sacrilege, and simony, highlighting the seriousness of upholding God's lordship.