The document discusses several studies on heme iron supplementation. It finds that heme iron: 1) Is not affected by other foods or drinks consumed simultaneously, unlike non-heme iron which can be inhibited. 2) Is absorbed as an intact molecule without releasing reactive iron ions, unlike non-heme iron. This avoids gastrointestinal side effects. 3) Does not compete with non-heme iron for absorption. 4) Has potential to complement anemia therapy, providing substantial savings and better quality of life for patients compared to pharmacological iron treatments.

1. FERRO da hemoglobina II
O que sabemos?
Mais alguns estudos publicados sobre suplementação com ferro heme:

2. EFFECT OF TEA AND OTHER DIETARY FACTORS ON IRON
ABSORPTION.
Zijp IM, Korver O, Tijburg LB.
Crit Rev Food Sci Nutr. 2000 Sep;40(5):371-98.
“Iron deficiency is a major world health problem, that is, to a great extent, caused by poor
iron absorpcon from the diet. Several dietary factors can influence this absorpcon.
Absorpcon enhancing factors are ascorbic acid and meat, fish and poultry; inhibicng
factors are plant components in vegetables, tea and coffee (e.g., polyphenols, phytates),
and calcium. Afer idencfying these factors their individual impact on iron absorpcon is
described. Specific agencon was paid to the effects of tea on iron absorpcon.. For
subjects at risk of iron deficecency the following recommendacons are made..Increase
heme-iron intake (this form of dietary iron present in meat fish and poultry is hardly
influenced by other dietary factors with respect to its absorpcon)..”
O ferro heme não é afetado por outros alimentos ou
bebidas ingeridos simultaneamente.

3. PROTON PUMP INHIBITORS SUPPRESS ABSORPTION OF
DIETARY NON-HAEM IRON IN HEREDITARY
HAEMOCHROMATOSIS.
Hutchinson C, Geissler CA, Powell JJ, Bomford A.
Gut. 2007 Sep;56(9):1291-5
“Low iron counts and even anaemia is often found in patiens using proton
pumb inhibitors such as Losec (omeprazole).
These drugs make stomach content less acidic.
A lowered gastric acid pH effectively stops non-heme iron uptake.”
Os largamente uclizados inibidores da bomba de
prótons, tais como Losec, por exemplo, impedem
a absorção de ferro não-heme e causam, em muitos
casos, a depleção de ferro.

4. PATHWAYS OF IRON ABSORPTION
Hutchinson C, Geissler CA, Powell JJ, Bomford A.
Gut. 2007 Sep;56(9):1291-5
“In the literature mechanisms for both organic (heme) and inorganic (non-
heme) iron uptake are well documented.
The special pathway through which heme iron is absorbed has great benefits,
mainly because the uptake is substantially higher.
Since the hemoglobin molecule is absorbed as a whole no free iron ions are
released in the intestine to trigger disturbancies."
O ferro heme não se desintegra antes de ser absorvido,
se comporta como uma estrutura inteira e não
compete com o ferro não-heme na absorção.

5. NON-HEME IRON AS FERROUS SULFATE DOES NOT
INTERACT WITH HEME IRON ABSORPTION IN HUMANS.
Gaitán D, Olivares M, Lönnerdal B, Brito A, Pizarro F.
Biol Trace Elem Res. 2012 Dec;150(1-3):68-73
“The addicon of non-heme iron as ferrous sulfate did not have any effect on heme
iron absorpcon (P = NS). We reported evidence that heme and non-heme iron as
ferrous sulfate does not compete for absorpcon".
Significa que o ferro heme não vai interagir com o ferro
não-heme na absorção ou eficácia.

6. PATHWAYS OF IRON ABSORPTION
Marcel E. Conrad and Jay N. Umbreit
Blood Cells, Molecules, and Diseases (2002) 29(3) Nov/Dec: 336–355
”Iron is vital for all living organisms but excess iron can be lethal because it facilitates
free radical formacon. Thus iron absorpcon is carefully regulated to maintain an
equilibrium between absorpcon and body loss of iron. In countries where meat is a
significant part of the diet, most body iron is derived from dietary heme because heme
binds few of the dietary chelators that bind inorganic iron.”
”Women eat less food than men and must absorb about 2 mg of iron daily during the
childbearing years in order to avoid becoming iron deficient.”
”Heme enters the enterocyte as an intact metalloporphyrin. Heme uptake is not
compeccve with non-heme iron.”
O ferro heme é absorvido como uma estrutura inteira,
sem se desintegrar e sem liberar os íons de ferro livre
reacvos causadores dos efeitos colaterais
gastrointescnais tão comuns.

7. HEME IRON-BASED DIETARY INTERVENTION FOR
IMPROVEMENT OF IRON STATUS IN YOUNG WOMEN.
Hoppe M, Brun B, Larsson MP, Moraeus L, Hulthen L.
Nutricon. 2013 Jan;29(1):89-95.
”Objeccve:
Convenconal iron deficiency treatment with pharmacologic iron doses ofen
causes side effects. Heme iron has high bioavailability and a low capacity to cause
gastrointescnal side effects. This study invescgated the possibility of using heme
iron in the form of blood-based crisp bread as a diet-based treatment program to
improve the iron status of women of reproduccve age.
Conclusion:
Dietary-based treatment containing heme iron has few side effects and can be
used efficiently to improve the iron status of women of reproduccve age.”
Produtos de ferro heme têm potencial para
complementar a terapia da anemia. Isto significaria
uma economia substancial para a comunidade e uma
muito melhor qualidade de vida para os pacientes.

8. HEME IRON-BASED DIETARY INTERVENTION FOR
IMPROVEMENT OF IRON STATUS IN YOUNG WOMEN.
Paz Etcheverry, Gordon E Carstens, Erin Brown, Keli M Hawthorne,
Zhensheng Chen, and Ian J Griffin
Am J Clin Nutr 2007;85:452–9.
”Background: The use of stable isotopes has provided valuable insights into iron
absorpcon in humans, but the data have been limited to nonheme iron.
Conclusions: Heme iron intrinsically labeled with 58 Fe can be produced
at sufficient enrichments for use in human studies. In children, heme iron and zinc
absorpcon decrease as the dose of each mineral increases. Heme iron did not
inhibit zinc absorpcon. At lower heme intakes, zinc intakes may increase heme-iron
absorpcon.
The current study suggests that geometric mean heme-iron absorpcon
from 4 mg heme iron (13–16%) is higher, consistent with the expectacon that
heme-iron absorpcon would be greater than nonheme-iron absorpcon.”
O ferro heme funciona bem com crianças e é absorvido
num grau maior do que o ferro não-heme.

9. OpcFer®
A série OpcFer® de suplementos de ferro heme é feita na Suécia
de acordo com as normas GMP e HACCP e possui todas as
cercficações. A dosagem normal é de um a dois comprimidos por
dia, a qualquer momento. A matéria-prima da série OpcFer®
é totalmente natural e não sintécca.
www.opcfer.internaconal
www.hemeiron.com