What do we know? Some more published studies of heme iron supplementation Heme iron is not affected by other simultaneously ingested food or drink. Proton-pump inhibitors such as Losec e.g stops the uptake of non-heme iron leading to iron depletion in many cases. Heme iron enters as a whole structure without disintegrating before uptake and does not compete with non-heme iron for uptake. There are few, if any, side-effects and good efficacy for heme iron when used with fertile females. Heme Iron works well with children and is absorbed to a greater degree than syntethic iron. It will also not inhibit zinc absorption. Heme iron will not interact with non-heme iron for uptake or efficacy. The uptake of heme iron is very high, up to 40 %

1. HEMOGLOBIN IRON II
What do we know?
Some more published studies of heme iron supplementation

2. EFFECT OF TEA AND OTHER DIETARY FACTORS ON
IRON ABSORPTION.
Zijp IM, Korver O, Tijburg LB.
Crit Rev Food Sci Nutr. 2000 Sep;40(5):371-98.
“Iron deficiency is a major world health problem, that is, to a great
extent, caused by poor iron absorption from the diet. Several dietary
factors can influence this absorption. Absorption enhancing factors are
ascorbic acid and meat, fish and poultry; inhibiting factors are plant
components in vegetables, tea and coffee (e.g., polyphenols, phytates),
and calcium. After identifying these factors their individual impact on
iron absorption is described. Specific attention was paid to the effects of
tea on iron absorption..
For subjects at risk of iron deficecency the following recommendations
are made..Increase heme-iron intake (this form of dietary iron present in
meat fish and poultry is hardly influenced by other dietary factors with
respect to its absorption)..”
Heme iron is not affected by other simultaneously
ingested food or drink.

3. PROTON PUMP INHIBITORS SUPPRESS ABSORPTION OF
DIETARY NON-HAEM IRON IN HEREDITARY
HAEMOCHROMATOSIS.
Hutchinson C, Geissler CA, Powell JJ, Bomford A.
Gut. 2007 Sep;56(9):1291-5
"Low iron counts and even anaemia is often found in patiens using
proton pumb inhibitors such as Losec (omeprazole).
These drugs make stomach content less acidic.
A lowered gastric acid pH effectively stops syntethic iron uptake."
Proton-pump inhibitors such as Losec e.g stops the
uptake of non-heme iron leading to iron depletion in
many cases.

4. PATHWAYS OF IRON ABSORPTION
Marcel E. Conrad and Jay N. Umbreit
Blood Cells, Molecules, and Diseases (2002) 29(3)
Nov/Dec: 336–355
"In the literature mechanisms for both organic (heme) and inorganic
(non-heme) iron uptake are well documented.
The special pathway through which heme iron is absorbed has great
benefits, mainly because the uptake is substantially higher.
Since the hemoglobin molecule is absorbed as a whole no free iron ions
are released in the intestine to trigger disturbancies."
Heme iron enters as a whole structure without
disintegrating before uptake and does not compete
with non-heme iron for uptake.

5. HEME IRON-BASED DIETARY INTERVENTION FOR
IMPROVEMENT OF IRON STATUS IN YOUNG WOMEN.
Hoppe M, Brun B, Larsson MP, Moraeus L, Hulthen L.
Nutrition. 2013 Jan;29(1):89-95.
"Heme iron tablets typically have a tolerance at placebo level, whereas
syntethic oral iron has a therapy failure rate due to side-effects of around 30
%
Heme iron products have the potential to complement anaemia therapy. This
would mean substantial savings for the community and a much improved
quality of life for the patients."
This means that there are few, if any, side-effects and good
efficacy for heme iron when used with fertile females.

6. PRODUCTION OF STABLE-ISOTOPE-LABELED BOVINE HEME
AND ITS USE TO MEASURE HEME-IRON ABSORPTION IN
CHILDREN.
Paz Etcheverry, Gordon E Carstens, Erin Brown, Keli M
Hawthorne, Zhensheng Chen, and Ian J Griffin
The American Journal of Clinical Nutrition Am J Clin Nutr
2007;85:452–9.
"The current study suggests that geometric mean heme-iron absorption
from 4 mg heme iron (13–16%) is higher, consistent with the expectation that
heme-iron absorption would be greater than nonheme-iron absorption."
Heme Iron works well with children and is absorbed to a
greater degree than syntethic iron. It will also not inhibit
zinc absorption.

7. NON-HEME IRON AS FERROUS SULFATE DOES NOT
INTERACT WITH HEME IRON ABSORPTION IN HUMANS.
Gaitán D, Olivares M, Lönnerdal B, Brito A, Pizarro F.
Biol Trace Elem Res. 2012 Dec;150(1-3):68-73
"The addition of non-heme iron as ferrous sulfate did not have any effect on
heme iron absorption (P = NS). We reported evidence that heme and non-
heme iron as ferrous sulfate does not compete for absorption."
Heme iron will not interact with non-heme iron for
uptake or efficacy.

8. PREDICTION OF DIETARY IRON ABSORPTION: AN
ALGORITHM FOR CALCULATING ABSORPTION AND
BIOAVAILABILITY OF DIETARY IRON.
Hallberg L, Hulthén L.
Am J Clin Nutr. 2000 May;71(5):1147-60.
” The basis for the algorithm was the absorption of iron from a wheat
roll (22.1 +/- 0.18%) containing no known inhibitors or enhancers of iron
absorption and adjusted to a reference dose absorption of 40%.”
The uptake of heme iron is very high, in this case 40
%