Fat leaves our body through lungs
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The document summarizes a study that found lungs are the primary organ for weight loss. When fat is oxidized, 8.4 kg leaves the body as carbon dioxide through the lungs, while 1.6 kg becomes water. To fully oxidize 10 kg of fat, 29 kg of oxygen must be inhaled, producing 28 kg of carbon dioxide and 11 kg of water. The researchers were surprised by these results, which show lungs are the primary means of excreting weight loss from the body through carbon dioxide.
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70% of indians eat non veg, but veg diet getting popular
While 70% of Indians still eat non-vegetarian diets, that number is expected to decline as a vegetarian diet becomes more popular due to increasing health awareness. Rising rates of lifestyle diseases are influencing people to change their diets. Additionally, international studies have shown vegetarians to be healthier than meat-eaters. However, consumption and purchase of chicken and fish is still growing rapidly in India.
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Forced to leave us, jobless researcher drags centre to hc
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70% of indians eat non veg, but veg diet getting popular
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- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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All info about Diabetes and how to control it.
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Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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Fat leaves our body through lungs
- 1. Fat leaves our body through lungs Brought to you by
- 2. Contd.. Ever wondered where the fat goes when we lose weight? Most of it is breathed out as carbon dioxide, according to a new study. Lungs are the primary excretory organ for weight loss, scientists have found. Ruben Meerman and Andrew Brown at the University of New South Wales set out to calculate how we “lose weight“. Human fat cells store triglyceride, which consists of just three kinds of atoms; carbon, hydrogen and oxygen.Shedding unwanted fat requires unlocking the atoms in triglyceride molecules by a process known as oxidation. Brought to you by
- 3. Contd.. By tracing every atom's pathway out of the body , the researchers discovered that when 10 kg of fat are fully oxidized, 8.4 kg departs via the lungs as carbon dioxide. The remaining 1.6 kg becomes water. The analysis showed that the inhaled oxygen required for this metabolic process weighs nearly three times more than the fat being `lost'. Brought to you by
- 4. Contd.. To completely oxidize 10kg of human fat, 29 kg of oxygen must be inhaled producing a total of 28 kg of carbon dioxide and 11 kg of water. “None of this biochemistry is new, but for unknown reasons it seems nobody has thought of performing these calculations before. The quantities make perfect sense but we were surprised by the numbers that popped out,“ the study authors wrote in the journal BMJ. “These results show that the lungs are the primary excretory organ for weight loss. The water formed may be excreted in the urine, faeces, sweat, breath, tears, or other bodily fluids and is readily replenished,“ they added. Brought to you by
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