The trailer begins with a 1950s style commercial depicting a nuclear war and persuading the audience to seek shelter underground. It then shows the protagonist leaving the underground vault into a post-apocalyptic wasteland with mutants, aliens and bandits. The trailer highlights the action RPG gameplay including exploration of the vast open world, combat against enemies using various weapons, and V.A.T.S targeting system. It utilizes 1950s retro visuals and music to set the tone for the post-apocalyptic setting.