This study investigates the factors influencing e-commerce adoption among Nigerian business organizations, analyzing data from 70 CEOs in Lagos. The results show that innovation culture, infrastructure, finance, knowledge and skills, compatibility, and security significantly predict e-commerce adoption, explaining 84% of its variance. The research concludes that improvements in infrastructure and security are critical for enhancing e-commerce utilization in Nigeria, with recommendations for government support and the establishment of an independent e-commerce agency.