This study examined the effects of Guna Reflux, a physiological regulating medicine, on 50 babies suffering from gastroesophageal reflux disease (GERD). The majority of babies experienced improvement in symptoms like regurgitation, restlessness, inability to gain weight, and arching of the head within 2-3 weeks. Specifically, 86.4% saw improvement and most recovered completely, while only 13.6% saw no improvement. No adverse reactions were reported. The study concludes that Guna Reflux is an excellent, safe remedy for treating GERD in babies with a high rate of success.