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Modelling	of	chronic	pa0ent	physical-ac0vity-
related	 behaviour	 towards	 healthy	 lifestyle	
support	
Kris0na	Livitckaia	
ESR	5	
Aristotle	University	of	Thessaloniki,	Greece	
This project has received funding from the European Union's Horizon 2020 research and innovation programme under the
Marie Sklodowska-Curie grant agreement No 676201
HYPOTHESIS	
Computa(onal	 models	 for	 pa(ent	
healthy	behaviour	and	lifestyle	support	
can	 allow	 to	 predict	 chronic	 pa(ent’s	
(non-)	 adherence	 to	 daily	 health-
related	 behaviour	 and	 choices	 with	
regard	 to	 the	 short-	 and/or	 long-term	
based	 on	 the	 combina(on	 of	
qualita0ve	 and	 quan0ta0ve	
determinants,	including		
											REFERENCES	
	
1.  Marks,	R.	(2005).	A	Review	and	Synthesis	of	Research	Evidence	for	Self-Efficacy-Enhancing	Interven(ons	for	Reducing	Chronic	Disability:	Implica(ons	for	Health	Educa(on	
Prac(ce	(Part	II).	Health	Promo(on	Prac(ce,	6(2),	148–156.	hTp://doi.org/10.1177/1524839904266792	
2.  Pavel,	M.,	Jimison,	H.	B.,	Korhonen,	I.,	Gordon,	C.	M.,	&	Saranummi,	N.	(2015).	Behavioral	Informa(cs	and	Computa(onal	Modeling	in	Support	of	Proac(ve	Health	Management	
and	Care.	IEEE	Transac(ons	on	Biomedical	Engineering,	62(12),	2763–2775.	hTp://doi.org/10.1109/TBME.2015.2484286	
3.  World	Health	Organiza(on.	(2005).	Preven(ng	Chronic	Diseases:	a	Vital	Investment.	World	Health,	202.hTp://doi.org/10.1093/ije/dyl098	
4.  WHO.www.who.int/chp/chronic_disease.	(2005).	Part	Two	-	The	urgent	need	for	ac(on.	Preven(ng	Chronic	Diseases:	A	Vital	Investment,	31–87	accessed	on	13/4/16.	Retrieved	
from	hTp://www.who.int/chp/chronic_disease_report/contents/en/	
5.  Halpin,	H.	A.,	Morales-Surez-Varela,	M.	M.,	&	Mar(n-Moreno,	J.	M.	(2010).	Chronic	disease	preven(on	and	the	new	public	health.	Public	Health	Reviews,	32(1),	120–154.	
6.  WHO	|	Physical	ac(vity.	(n.d.).	Retrieved	July	6,	2016,	from	hTp://www.who.int/mediacentre/factsheets/fs385/en/#.V3zVyEWiT1k.mendeley	
BACKGROUND	
Connected	 health	 is	 a	 concept	 for	 preserving	 ci(zens’	 health	 and	 well-being	 by	 providing	 technologically	
enhanced	proac(ve	and	pa(ent-centered	health	services,	e.g.	interven(ons.	In	its	turn,	pa(ent-centered	care	
demands	 pa0ent	 adherence	 and	 compliance	 to	 healthy	 behaviour	 and	 lifestyle	 choices.	 If	 pa(ents	 are	
adherent	 to	 the	 process	 of	 disease	 self-management,	 it	 reduces	 the	 propor(on	 of	 those	 pa(ents	 who	 ignore	
prescribed	recommenda(ons	and	lose	faith	in	the	desirable	and	poten(ally	achievable	outcomes	1.			
Despite	 a	 solid	 number	 of	 evidence-based	 inves(ga(ons	 regarding	 the	 rela(on	 of	 control	 and	 preven(on	 of	
chronic	 diseases	 to	 pa(ent	 health	 behaviour	 adherence,	 there	 is	 a	 limited	 research	 taking	 into	 considera(on	
unified	pa(ent	characteris(cs	from	mul(faceted	backgrounds	and	aspects	(e.g.	medicine,	psychology,	sociology,	
lifestyle,	 etc.).	 While	 the	 key	 towards	 successful	 Connected	 health	 interven(ons	 development	 lies	 under	
personaliza0on	 and	 tailoring	 to	 a	 pa(ent	 by	 taking	 into	 account	 and	 adap(ng	 to	 addi0onal	 lifestyle	
factors	and	determinants	2,3.		In	this	context,	there	is	a	need	for	extended	analysis	for	health	behaviour	
understanding	 and	 predic(on,	 beneficial	 to	 improvement	 and	 tailoring	 of	 interven(ons	 through	 technological	
solu(ons	2.	
The	 aim	 of	 the	 research	 is	 to	 propose	 improvements	 for	 interven(ons	 design	 with	 regard	 to	 qualita(ve	 and	
quan(ta(ve	pa(ent	characteris(cs,	states	and	contextual	factors	to	allow	pa(ent	behaviour	predic(ons	paTerns	
for	pa(ent	behavioural	support.	
RESEARCH	SCOPE	
Cardiovascular	 diseases	 are	 the	 most	
common	chronic	illness	that	characterizes	
the	 state	 of	 public	 health	 and	 has	 a	
notable	 effect	 on	 major	 global	 indexes	 of	
morbidity,	 disability	 and	 mortality	 4.	
Ongoing	 increase	 in	 the	 incidence	 of	
cardiovascular	diseases	is	oken	associated	
with	 unhealthy	 lifestyle	 choices,	 including	
lack	 of	 physical	 ac(vity,	 smoking,	 and	
other	 health-related	 bahaviours	 3,4,5.	
Moreover,	physical	inac0vity	is	one	of	
the	key	risk	factors	for	non-communicable	
diseases	such	as	coronary	heart	disease	6.		
The	scope	of	the	research	comprises	predic(ve	modelling	
of	cardiac	chronic	pa(ent’s	adherence	to	physical-ac(vity-
related	behaviour.		
PHASE	I	
Inves(ga(on	of	chronic	
pa(ents’	determinants	and	
risk	factors	affec(ng	(non-)	
adherence	to	physical	ac(vity	
and	exercise	behaviour	
PHASE	II	
Inves(ga(on	of	methods	of	
mathema(cal	and	
computa(onal	predic(ve	
modeling	and	data	mining	
techniques	
PHASE	III	
Valida(on	of	set	of	
computa(onal	models	for	
pa(ent	health-related	
adherence	level	predic(on	at	
different	(me	scales	
PROCESS	
Forma(on	 of	 qualita(ve	
and	 quan(ta(ve	 poten(al	
a T r i b u t e s 	 a n d	
determinants	 of	 a	 pa(ent	
adherence	 to	 physical	
ac(vity-related	 behaviour	
f o r	 f u r t h e r	 ( n o n - )	
adherence	 predic(on	
inves(ga(on	
PROCESS	
D e v e l o p m e n t 	 o f	
computa(onal	 models	
based	 on	 inves(gated	
determinants	and	paTerns	
for	 predic(on	 of	 pa(ent	
(non-)	 adherence	 level	 to	
physical-ac(vity-related	
behaviour	
PROCESS	
Valida(on	 and	 improvement	
of	 computa(onal	 models	
based	 on	 the	 data	 sets	
s u p p o r t e d 	 b y 	 t h e	
collabora(on	 with	 the	
Laboratory	 of	 Compu0ng	
and	 Medical	 Informa0cs,	
and	 the	 Laboratory	 of	
Sports	Medicine,	Aristotle	
University	of	Thessaloniki,	
Greece	
Study	with	
pa0ent	group	
Determinants	rela0ons	and	affects	
Models	
valida0on	
Predic0ve	
modelling	
					Drawn	conclusions	
§  Currently	 applied	 approaches	 to	 the	 segmenta(on	 and	
predic(ve	 modeling	 of	 pa(ents’	 physical-ac(vity-related	
behaviour,	 oken	 take	 into	 account	 only	 clinical	 or	
psychological	aspects	
§  Need	 for	 extended	 analysis	 for	 health	 behaviour	
understanding	and	predic(on,	beneficial	to	improvement	of	
behavioural	interven(ons	technologies	
COMPUTATIONAL	APPROACHES	
Exis(ng	solu(ons	inves(ga(on	
§  Systema(c	 literature	 review	 for	 inves(ga(on	 of	
informa(on	systems	and	its	components	developed	for	
chronic	pa(ents’	health	behavior	modifica(on	
§  Conducted	 databases:	 IEEE	 Xplore,	 the	 ACM	 Digital	
Library	PubMed,	WIPO	Patentscope,	Espacenet,	USPTO	
§  Advanced	search	strategy	
§  Main	 concepts:	 health	 behaviour	 change	 and	
computa0onal	modelling	
Classifica0on	of	the	results	
§  Stage	of	the	development	
§  Deployment	sepngs	
§  Group	of	pa(ents		
§  Interven(on	sepngs	
§  Target	health	behaviour	
§  Underlying	mul(disciplinary	
domains	
§  Sources	and	types	of	
consumer	data	
§  Data	processing	techniques	
§  Level	of	personaliza(on	
§  Evalua(on	
§  Improvement	goals	
PHYSICAL-ACTIVITY-RELATED	ADHERENCE	DETERMINANTS	
	
					Clinically	proven	pa(ents’	determinants	
§  Literature	review	based	on	the	standard	methodological	
framework	
§  Conducted	databases:	PubMed	and	Cochrane	Library	
§  Advanced	search	strategy	
§  Main	 concepts:	 influence	 factors,	 adherence	 to	
physical-ac0vity-related	 behaviour,	 heart	
diseases
Search	results	
GAPS	IDENTIFIED	
§  Lack	of	lifestyle	health-related	data	inves(ga(on	and	its	affec(ng	
power	to	pa(ent	adherence	
§  Lack	of	inves(ga(on	of	rela(ons	among	defined	determinants	
§  Need	 for	 inves(ga(on	 of	 pa(ent	 physical	 ac(vity	 and	 exercise	
long-term	adherence	
Rela0on		of	determinants	to	adherence	
Defined	determinants

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  • 1. Modelling of chronic pa0ent physical-ac0vity- related behaviour towards healthy lifestyle support Kris0na Livitckaia ESR 5 Aristotle University of Thessaloniki, Greece This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 676201 HYPOTHESIS Computa(onal models for pa(ent healthy behaviour and lifestyle support can allow to predict chronic pa(ent’s (non-) adherence to daily health- related behaviour and choices with regard to the short- and/or long-term based on the combina(on of qualita0ve and quan0ta0ve determinants, including REFERENCES 1.  Marks, R. (2005). A Review and Synthesis of Research Evidence for Self-Efficacy-Enhancing Interven(ons for Reducing Chronic Disability: Implica(ons for Health Educa(on Prac(ce (Part II). Health Promo(on Prac(ce, 6(2), 148–156. hTp://doi.org/10.1177/1524839904266792 2.  Pavel, M., Jimison, H. B., Korhonen, I., Gordon, C. M., & Saranummi, N. (2015). Behavioral Informa(cs and Computa(onal Modeling in Support of Proac(ve Health Management and Care. IEEE Transac(ons on Biomedical Engineering, 62(12), 2763–2775. hTp://doi.org/10.1109/TBME.2015.2484286 3.  World Health Organiza(on. (2005). Preven(ng Chronic Diseases: a Vital Investment. World Health, 202.hTp://doi.org/10.1093/ije/dyl098 4.  WHO.www.who.int/chp/chronic_disease. (2005). Part Two - The urgent need for ac(on. Preven(ng Chronic Diseases: A Vital Investment, 31–87 accessed on 13/4/16. Retrieved from hTp://www.who.int/chp/chronic_disease_report/contents/en/ 5.  Halpin, H. A., Morales-Surez-Varela, M. M., & Mar(n-Moreno, J. M. (2010). Chronic disease preven(on and the new public health. Public Health Reviews, 32(1), 120–154. 6.  WHO | Physical ac(vity. (n.d.). Retrieved July 6, 2016, from hTp://www.who.int/mediacentre/factsheets/fs385/en/#.V3zVyEWiT1k.mendeley BACKGROUND Connected health is a concept for preserving ci(zens’ health and well-being by providing technologically enhanced proac(ve and pa(ent-centered health services, e.g. interven(ons. In its turn, pa(ent-centered care demands pa0ent adherence and compliance to healthy behaviour and lifestyle choices. If pa(ents are adherent to the process of disease self-management, it reduces the propor(on of those pa(ents who ignore prescribed recommenda(ons and lose faith in the desirable and poten(ally achievable outcomes 1. Despite a solid number of evidence-based inves(ga(ons regarding the rela(on of control and preven(on of chronic diseases to pa(ent health behaviour adherence, there is a limited research taking into considera(on unified pa(ent characteris(cs from mul(faceted backgrounds and aspects (e.g. medicine, psychology, sociology, lifestyle, etc.). While the key towards successful Connected health interven(ons development lies under personaliza0on and tailoring to a pa(ent by taking into account and adap(ng to addi0onal lifestyle factors and determinants 2,3. In this context, there is a need for extended analysis for health behaviour understanding and predic(on, beneficial to improvement and tailoring of interven(ons through technological solu(ons 2. The aim of the research is to propose improvements for interven(ons design with regard to qualita(ve and quan(ta(ve pa(ent characteris(cs, states and contextual factors to allow pa(ent behaviour predic(ons paTerns for pa(ent behavioural support. RESEARCH SCOPE Cardiovascular diseases are the most common chronic illness that characterizes the state of public health and has a notable effect on major global indexes of morbidity, disability and mortality 4. Ongoing increase in the incidence of cardiovascular diseases is oken associated with unhealthy lifestyle choices, including lack of physical ac(vity, smoking, and other health-related bahaviours 3,4,5. Moreover, physical inac0vity is one of the key risk factors for non-communicable diseases such as coronary heart disease 6. The scope of the research comprises predic(ve modelling of cardiac chronic pa(ent’s adherence to physical-ac(vity- related behaviour. PHASE I Inves(ga(on of chronic pa(ents’ determinants and risk factors affec(ng (non-) adherence to physical ac(vity and exercise behaviour PHASE II Inves(ga(on of methods of mathema(cal and computa(onal predic(ve modeling and data mining techniques PHASE III Valida(on of set of computa(onal models for pa(ent health-related adherence level predic(on at different (me scales PROCESS Forma(on of qualita(ve and quan(ta(ve poten(al a T r i b u t e s a n d determinants of a pa(ent adherence to physical ac(vity-related behaviour f o r f u r t h e r ( n o n - ) adherence predic(on inves(ga(on PROCESS D e v e l o p m e n t o f computa(onal models based on inves(gated determinants and paTerns for predic(on of pa(ent (non-) adherence level to physical-ac(vity-related behaviour PROCESS Valida(on and improvement of computa(onal models based on the data sets s u p p o r t e d b y t h e collabora(on with the Laboratory of Compu0ng and Medical Informa0cs, and the Laboratory of Sports Medicine, Aristotle University of Thessaloniki, Greece Study with pa0ent group Determinants rela0ons and affects Models valida0on Predic0ve modelling Drawn conclusions §  Currently applied approaches to the segmenta(on and predic(ve modeling of pa(ents’ physical-ac(vity-related behaviour, oken take into account only clinical or psychological aspects §  Need for extended analysis for health behaviour understanding and predic(on, beneficial to improvement of behavioural interven(ons technologies COMPUTATIONAL APPROACHES Exis(ng solu(ons inves(ga(on §  Systema(c literature review for inves(ga(on of informa(on systems and its components developed for chronic pa(ents’ health behavior modifica(on §  Conducted databases: IEEE Xplore, the ACM Digital Library PubMed, WIPO Patentscope, Espacenet, USPTO §  Advanced search strategy §  Main concepts: health behaviour change and computa0onal modelling Classifica0on of the results §  Stage of the development §  Deployment sepngs §  Group of pa(ents §  Interven(on sepngs §  Target health behaviour §  Underlying mul(disciplinary domains §  Sources and types of consumer data §  Data processing techniques §  Level of personaliza(on §  Evalua(on §  Improvement goals PHYSICAL-ACTIVITY-RELATED ADHERENCE DETERMINANTS Clinically proven pa(ents’ determinants §  Literature review based on the standard methodological framework §  Conducted databases: PubMed and Cochrane Library §  Advanced search strategy §  Main concepts: influence factors, adherence to physical-ac0vity-related behaviour, heart diseases Search results GAPS IDENTIFIED §  Lack of lifestyle health-related data inves(ga(on and its affec(ng power to pa(ent adherence §  Lack of inves(ga(on of rela(ons among defined determinants §  Need for inves(ga(on of pa(ent physical ac(vity and exercise long-term adherence Rela0on of determinants to adherence Defined determinants