eRNA_QTL_website.pptx
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The document describes a web portal for exploring expression quantitative trait loci (eRNA-QTLs) using data from the Genotype-Tissue Expression (GTEx) project. It involves the following: - Genotype and expression data from 838 donors across 54 tissues and cell lines were obtained from GTEx. - eRNA-QTLs were identified using a permutation test and linear regression accounting for covariates, with associations below a 5% FDR threshold retained. - The portal allows users to query eRNA-QTLs of interest, visualize them on a genome browser, view GWAS colocalization, and download eRNA-QTL data.
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eRNA_QTL_website.pptx
This document provides a step-by-step guide to using a web portal for exploring expression quantitative trait loci (eQTLs) of enhancer RNAs (eRNAs). It analyzes eRNA expression and genotype data from the GTEx project across 54 tissues and cell lines. The portal allows users to query for eRNA-eQTLs, view them in a genome browser, visualize eRNA-eQTL and GWAS colocalization, search for disease-associated eRNA-eQTLs, and download eRNA-eQTL data.
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Corrected slides: dtubbenhauer.com/talks.html
The binding of cosmological structures by massless topological defects
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field
equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational
field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin
spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling
concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect
light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is
mitigated, at least in part.
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