Enstilar is a topical treatment for psoriasis that combines betamethasone dipropionate, a corticosteroid, and calcipotriene, a vitamin D3 analogue. It has been shown to be more effective than its individual components in clinical trials. While effective, topical treatments can have low patient adherence long-term due to irritation. New formulations using nanostructured lipid carriers could potentially enhance skin retention and reduce irritation, improving adherence to Enstilar.