EndNote is a reference management program that allows users to create personal reference libraries, insert citations into Word documents, and generate bibliographies. Key features include creating and backing up libraries, searching databases, manually entering references, importing PDFs to create references, organizing and editing references, finding full text files, and more. Users can sort, edit, update, and delete references as needed. Smart groups and group sets help organize the library. The document provides instructions on performing various tasks in EndNote like creating a new library, backing up a library, importing PDFs, and finding full text files for references.