What are new chemical substance regulations in China? And what are toxic chemical substance regulations in China? How to compliant with these regulations? What inventories can be referred? How enterprises to determine their obligations? Answers can be found in CIRS free webinar for chemical regulations & compliance in China.
This webinar will introduce current chemical management regulations in China and how to fulfill enterprises’ obligations under these regulations. Detailed operationwill be summarized here for GHS and regulatory specialist and related stake-holders to well-understand and follow up.
Just providing the information on Impurities in drug substances & Drug products to share my view and the collected information from the web for knowledge purpose.
This presentation is compiled from freely available resources like the websites of FDA, EMA ,WHO and research papers published by experts in this field like Sandle, T Reinmüller, B , Hyde, W,, Costello, E.K., Lauber, C. L., Hamady, M., Fierer, N., Gordon, J.I., Knight, R.
Paper published by T. Sandle on clean room contamination was referred extensively for this presentation. “Drug Regulations” is a non profit organization which provides free online resource to the Pharmaceutical Professional.
Visit http://www.drugregulations.org for latest information from the world of Pharmaceuticals.
Introduction to the EU REACH Program and California’s Green Chemicals Initiative - REACH & Beyond: Workshop on the Changing Nature of Chemicals Management - December 15, 2008, Sunnyvale, California
Just providing the information on Impurities in drug substances & Drug products to share my view and the collected information from the web for knowledge purpose.
This presentation is compiled from freely available resources like the websites of FDA, EMA ,WHO and research papers published by experts in this field like Sandle, T Reinmüller, B , Hyde, W,, Costello, E.K., Lauber, C. L., Hamady, M., Fierer, N., Gordon, J.I., Knight, R.
Paper published by T. Sandle on clean room contamination was referred extensively for this presentation. “Drug Regulations” is a non profit organization which provides free online resource to the Pharmaceutical Professional.
Visit http://www.drugregulations.org for latest information from the world of Pharmaceuticals.
Introduction to the EU REACH Program and California’s Green Chemicals Initiative - REACH & Beyond: Workshop on the Changing Nature of Chemicals Management - December 15, 2008, Sunnyvale, California
This presentation is aimed at interpreting these significant changes with special focus on strictly-controlled products such as infant formula and health food and the food traceability system that is newly required to be set up. Both importers and exporters can expect to figure out what they should do for compliance and learn about further trends of regulatory updates following the implementation of the new FSL.
CCK Discussion Forum on Impurity Emergence: A Wake Up Call for Drug Safety & Quality - 13 Oct 2019 at ICCBS, University of Karachi. Session largely participated by qualified and experienced pharmaceutical professionals having diversified educational background and experience.
TOP PLAYERS FILING PATENTS CLASSIFIED UNDER INTERNATIONAL PATENT CLASSIFICATION (IPC) A47: MATSUSHITA ELECTRIC IND CO LTD, LG ELECTRONICS INC, TOTO LTD, SANYO ELECTRIC CO LTD, BSH BOSCH, SIEMENS HAUSGERAETE, KOKUYO CO LTD
IPC DESCRIPTION
A47B
TABLES; DESKS; OFFICE FURNITURE; CABINETS; DRAWERS; GENERAL DETAILS OF FURNITURE (furniture jointing F16B)
A47C
CHAIRS (seats specially adapted for vehicles B60N 2/00); SOFAS; BEDS (upholstery in general B68G)
A47D
FURNITURE SPECIALLY ADAPTED FOR CHILDREN (school benches or desks A47B 39/00, A47B 41/00)
A47F
SPECIAL FURNITURE, FITTINGS, OR ACCESSORIES FOR SHOPS, STOREHOUSES, BARS, RESTAURANTS, OR THE LIKE; PAYING COUNTERS
Genentech, Novartis, Monsanto, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA,
PIONEER HI-BRED INTERNATIONAL, INC., NOVARTIS AG, Monsanto Technology LLC,
ROCHE DIAGNOSTICS GMBH Top Patent filers & Patent recipients classified under the IPC C12.
Inventions in the field of Biochemistry & Genetic Engineering include-
Preparation of wine and other alcoholic beverages.
Preparation of Vinegar.
Apparatus for enzymology and microbiology.
Composition of microbes and enzymes.
Fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture
The European Commission Health and Consumers Directorate – General has published a draft “GUIDELINES ON THE PRINCIPLES OF GOOD DISTRIBUTION PRACTICES FOR ACTIVE SUBSTANCES FOR MEDICINAL PRODUCTS FOR HUMAN USE”.
The guideline addresses Quality systems, Personnel, Documentation, Order, Procedures, Records, Premises and Equipment, Receipts, Storage , Deliveries to Customers, Transfer of Information and Returns.
Following presentation is prepared by “ Drug Regulations” a non profit organization which provides free online resource to the Pharmaceutical Professional.
Setting Specification Limits for Impurities in Active Pharmaceutical Ingredient (API’s).
Setting Specification Limits for Impurities in Active Pharmaceutical Ingredient (API’s)
Setting Specification Limits for Impurities in Active Pharmaceutical Ingredient (API’s)
Drug Regulations is a Not for Profit Organizations which provides free online resources for the Pharmaceutical Professional. This presentation is part G of series of presentations which addresses the current Good Manufacturing Requirements as per the US FDA. This presentation addresses : : Packaging & Labeling Control
In the month of February 2014 US Food and Drug Administration Commissioner Margaret Hamburg visited India to discuss issues of drug quality with her counterparts in the Indian Government. The FDA has imposed a rash of regulatory sanctions on Indian generic makers in the last year, triggering concerns about the quality of the medicines supplied by the $14 billion industry to countries including the United States, the biggest market. India is second only to Canada as a drug exporter to the United States, where it supplies about 40 percent of generic and over-the-counter drugs.There were comments made about the US and Indian GMP Standards. Drug Regulations has now compared the GMP standards of US and India. The comparison is given in the presentation here.
[Infographic] A One Page Guide to Global GDP GuidelinesPharma IQ
http://www.coldchainiq.com/regulatory-resources/white-papers/a-one-page-guide-to-global-gdp-guidelines/
All GDP guidelines in one single place!
Good Distribution Practice (GDP) is the part of quality assurance which ensures that products are consistently stored, transported and handled under suitable condition as required by the marketing authorisation (MA) or product specification. There is no single global GDP standard. Cold Chain IQ has created this easy to-assimilate summary of GDP requirements around the world, enabling you to navigate the landscape. You can keep it as a handy reference, share it around your colleagues or even stick it on your wall!
EU and US Procedures for API Registration - Commonalities and DifferencesMerck Life Sciences
View the interactive recording here: https://bit.ly/2PB0VZo
Abstract:
This webinar will review the current requirements for the active substance registration in the European Union and the USA. First, we will summarize the authority regulations for APIs in the EU and USA and show the similarities and differences of procedures such as CEP, AMSF, and US-DMF. Secondly, we’ll cover new trends and requirements for API-dossiers such as the control of elemental impurities according to the new international guideline ICH Q3D and related watchouts for CEPs. At the end of the presentation, we’ll discuss the eCTD roadmap for the future and the end of paper submissions.
Taiwan chemical substance registration analysis and supervision measures updateYichen (Ethan) Zheng
How is the progress of Taiwan chemical regulations? How are the Taiwan Customs supervision measures going? What are the differences between Pre-Registration and Late Pre-Registration? What about the CBI protection under Taiwan chemical regulations? Experts from CIRS will make interpretations of all the above mentioned contents and will bring you some take home messages for enterprises.
This presentation is aimed at interpreting these significant changes with special focus on strictly-controlled products such as infant formula and health food and the food traceability system that is newly required to be set up. Both importers and exporters can expect to figure out what they should do for compliance and learn about further trends of regulatory updates following the implementation of the new FSL.
CCK Discussion Forum on Impurity Emergence: A Wake Up Call for Drug Safety & Quality - 13 Oct 2019 at ICCBS, University of Karachi. Session largely participated by qualified and experienced pharmaceutical professionals having diversified educational background and experience.
TOP PLAYERS FILING PATENTS CLASSIFIED UNDER INTERNATIONAL PATENT CLASSIFICATION (IPC) A47: MATSUSHITA ELECTRIC IND CO LTD, LG ELECTRONICS INC, TOTO LTD, SANYO ELECTRIC CO LTD, BSH BOSCH, SIEMENS HAUSGERAETE, KOKUYO CO LTD
IPC DESCRIPTION
A47B
TABLES; DESKS; OFFICE FURNITURE; CABINETS; DRAWERS; GENERAL DETAILS OF FURNITURE (furniture jointing F16B)
A47C
CHAIRS (seats specially adapted for vehicles B60N 2/00); SOFAS; BEDS (upholstery in general B68G)
A47D
FURNITURE SPECIALLY ADAPTED FOR CHILDREN (school benches or desks A47B 39/00, A47B 41/00)
A47F
SPECIAL FURNITURE, FITTINGS, OR ACCESSORIES FOR SHOPS, STOREHOUSES, BARS, RESTAURANTS, OR THE LIKE; PAYING COUNTERS
Genentech, Novartis, Monsanto, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA,
PIONEER HI-BRED INTERNATIONAL, INC., NOVARTIS AG, Monsanto Technology LLC,
ROCHE DIAGNOSTICS GMBH Top Patent filers & Patent recipients classified under the IPC C12.
Inventions in the field of Biochemistry & Genetic Engineering include-
Preparation of wine and other alcoholic beverages.
Preparation of Vinegar.
Apparatus for enzymology and microbiology.
Composition of microbes and enzymes.
Fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture
The European Commission Health and Consumers Directorate – General has published a draft “GUIDELINES ON THE PRINCIPLES OF GOOD DISTRIBUTION PRACTICES FOR ACTIVE SUBSTANCES FOR MEDICINAL PRODUCTS FOR HUMAN USE”.
The guideline addresses Quality systems, Personnel, Documentation, Order, Procedures, Records, Premises and Equipment, Receipts, Storage , Deliveries to Customers, Transfer of Information and Returns.
Following presentation is prepared by “ Drug Regulations” a non profit organization which provides free online resource to the Pharmaceutical Professional.
Setting Specification Limits for Impurities in Active Pharmaceutical Ingredient (API’s).
Setting Specification Limits for Impurities in Active Pharmaceutical Ingredient (API’s)
Setting Specification Limits for Impurities in Active Pharmaceutical Ingredient (API’s)
Drug Regulations is a Not for Profit Organizations which provides free online resources for the Pharmaceutical Professional. This presentation is part G of series of presentations which addresses the current Good Manufacturing Requirements as per the US FDA. This presentation addresses : : Packaging & Labeling Control
In the month of February 2014 US Food and Drug Administration Commissioner Margaret Hamburg visited India to discuss issues of drug quality with her counterparts in the Indian Government. The FDA has imposed a rash of regulatory sanctions on Indian generic makers in the last year, triggering concerns about the quality of the medicines supplied by the $14 billion industry to countries including the United States, the biggest market. India is second only to Canada as a drug exporter to the United States, where it supplies about 40 percent of generic and over-the-counter drugs.There were comments made about the US and Indian GMP Standards. Drug Regulations has now compared the GMP standards of US and India. The comparison is given in the presentation here.
[Infographic] A One Page Guide to Global GDP GuidelinesPharma IQ
http://www.coldchainiq.com/regulatory-resources/white-papers/a-one-page-guide-to-global-gdp-guidelines/
All GDP guidelines in one single place!
Good Distribution Practice (GDP) is the part of quality assurance which ensures that products are consistently stored, transported and handled under suitable condition as required by the marketing authorisation (MA) or product specification. There is no single global GDP standard. Cold Chain IQ has created this easy to-assimilate summary of GDP requirements around the world, enabling you to navigate the landscape. You can keep it as a handy reference, share it around your colleagues or even stick it on your wall!
EU and US Procedures for API Registration - Commonalities and DifferencesMerck Life Sciences
View the interactive recording here: https://bit.ly/2PB0VZo
Abstract:
This webinar will review the current requirements for the active substance registration in the European Union and the USA. First, we will summarize the authority regulations for APIs in the EU and USA and show the similarities and differences of procedures such as CEP, AMSF, and US-DMF. Secondly, we’ll cover new trends and requirements for API-dossiers such as the control of elemental impurities according to the new international guideline ICH Q3D and related watchouts for CEPs. At the end of the presentation, we’ll discuss the eCTD roadmap for the future and the end of paper submissions.
Taiwan chemical substance registration analysis and supervision measures updateYichen (Ethan) Zheng
How is the progress of Taiwan chemical regulations? How are the Taiwan Customs supervision measures going? What are the differences between Pre-Registration and Late Pre-Registration? What about the CBI protection under Taiwan chemical regulations? Experts from CIRS will make interpretations of all the above mentioned contents and will bring you some take home messages for enterprises.
Failure is not an option, or, why you need to ask 'Why?" more often.Alessandro Galetto
We should answer a simple question: "Why companies are built and managed in the way we know?".
In this presentation I will give my answer from an historic, scientific and economic perspective, and, at the same, I will try to show why other models are possible.
Different organisational models are not only possible, but needed when the current models are causing so much pain in modern companies.
We need to reinvent the way company works as well as we must reinvent the definition of career in the 21st century.
We have so many tools and the higher amount of technology that we can use to shape the future of our companies. Which is the reason why we are not doing anything about it?
Even if the presentation is definitely focused on the Italian market it contains elements and ideas that have a broader ranged of applicability.
And, as always, it's not too serious.
I used this presentation for my talk at the Better Software 2013 conference in Florence.
When we think of hope, so many thoughts come to mind, so many images and now, so many colors. Bring these colors of HOPE into our home. Think Holistic. These are the colors that feel good in our homes!
New Product Registration - Key Considerations when Registering New ProductsCovance
The regulation related to the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) was adopted by the EU in 2007 in response to worldwide initiatives to address the impact of chemicals on human health and the environment. REACH requires all manufacturers and importers of chemicals into European markets to assess and manage the risks associated with their substances and products, and register them with the European Chemicals Agency (ECHA). To manage this project, ECHA split existing substances into three categories, based on the amount of the substance that is used annually, with different registration deadlines for different tonnages of use.
Animal testing safety endpoints in chemical industryMIHIR PUJARA
This presentation describes animal testing safety end points in chemical industry according to REACH(registration,evaluation,authorisation & restriction of chemicals).
REACH was established to control manufacturing and importing of chemicals in EU market & to minimize the risks to human health and environment.
K-REACH - How to Prepare for the K-REACH LegislationCovance
In 2015, South Korea introduced legislation designed to protect human health and the environment from the impact of chemicals. The two pieces of legislation introduced were the: Act on the Registration and Evaluation of Chemicals (K-REACH), which mandates the registration of all new and existing chemicals marketed or imported into South Korea at ≥1 metric ton per year, requiring detailed information on their likely hazard to human health and the environment and the Chemicals Control Act (CCA), which focuses on chemical reporting and chemical accident prevention.
On December 18, 2006, the European Parliament passed the final REACH Directive. Work on this legislation began in 2003. REACH will begin to be phased in on June 1, 2007.
REACH is an acronym that stands for “Registration, Evaluation and Authorisation of Chemicals”. REACH replaces about 40 different EU regulations and provides a uniform approach to evaluating, approving, and if necessary, restricting the manufacture, import and uses of chemicals within EU Member States. Because REACH also addresses the uses of chemicals, this directive can have a direct impact on a wide range of organizations.
This regulatory briefing provides a summary of some of the key elements and concepts of the REACH Directive. For more information on EH&S and product responsibility services, go to:
http://calthacompany.com/compliance-programs-ems-auditing
What Supply Chain Managers need to do to meet effectively comply with REACH ?
By Philip Capel
LogiChem 2011 will be the event's tenth anniversary and an opportunity for the most senior chemical supply chain & global logistics directors from the European chemicals community to come together once again share experiences, make new contacts and benchmark the latest chemical supply chain initiatives.
Not only will LogiChem 2011 be a chance for the chemical industry to reminisce about the last ten years but an opportunity to shape the next decade. To celebrate a decade of LogiChem, there will be an exciting three day programme filled with networking opportunities in our new location, Antwerp.
Slides for the eLearning course Separation and purification processes in biorefineries (https://open-learn.xamk.fi) in IMPRESS project (https://www.spire2030.eu/impress).
Section: Mass transfer processes
Subject: 3.3 Safety issues
Part two of the compliance webinar series will be about customizing your solution to meet your specific needs in compliance. This will include the use of process extension and data import tools that assist with bringing all your compliance information into the Agile system.
Overcoming the stress of non-prescription medicine application screening - Co...TGA Australia
This presentation will describe how the TGA undertakes the screening process and will discuss the mandatory requirements for applications, including specific examples of problems commonly encountered.
US Toxic Substances Control Act (TSCA) ReformCovance
The Toxic Substances Control Act (TSCA) Public Law 94-469, was first signed into Law on October 11, 1976 due to the use of a large number of chemicals in the United States (US) and exposure to human health or the environment. This act was recently updated under 'The Frank R. Lautenberg Chemical Safety for the 21st Century Act', Public Law 114-182, and was signed into Law on June 22, 2016 by US President Obama. The scope of the reform does not include; pesticides, tobacco, nuclear materials, food, drugs or cosmetics. TSCA allows the Environmental Protection Agency (EPA) to assess chemical risks to human health and the environment and to take action to control these risks. In summary, TSCA authorizes the EPA to keep an 'inventory' of all existing chemicals. Currently the inventory comprises approximately 83,000 chemicals that are being manufactured or imported into the US. Chemicals on the inventory can be manufactured or imported into the US, chemicals that are not on the inventory cannot be manufactured or imported into the US.
WRI’s brand new “Food Service Playbook for Promoting Sustainable Food Choices” gives food service operators the very latest strategies for creating dining environments that empower consumers to choose sustainable, plant-rich dishes. This research builds off our first guide for food service, now with industry experience and insights from nearly 350 academic trials.
Natural farming @ Dr. Siddhartha S. Jena.pptxsidjena70
A brief about organic farming/ Natural farming/ Zero budget natural farming/ Subash Palekar Natural farming which keeps us and environment safe and healthy. Next gen Agricultural practices of chemical free farming.
Diabetes is a rapidly and serious health problem in Pakistan. This chronic condition is associated with serious long-term complications, including higher risk of heart disease and stroke. Aggressive treatment of hypertension and hyperlipideamia can result in a substantial reduction in cardiovascular events in patients with diabetes 1. Consequently pharmacist-led diabetes cardiovascular risk (DCVR) clinics have been established in both primary and secondary care sites in NHS Lothian during the past five years. An audit of the pharmaceutical care delivery at the clinics was conducted in order to evaluate practice and to standardize the pharmacists’ documentation of outcomes. Pharmaceutical care issues (PCI) and patient details were collected both prospectively and retrospectively from three DCVR clinics. The PCI`s were categorized according to a triangularised system consisting of multiple categories. These were ‘checks’, ‘changes’ (‘change in drug therapy process’ and ‘change in drug therapy’), ‘drug therapy problems’ and ‘quality assurance descriptors’ (‘timer perspective’ and ‘degree of change’). A verified medication assessment tool (MAT) for patients with chronic cardiovascular disease was applied to the patients from one of the clinics. The tool was used to quantify PCI`s and pharmacist actions that were centered on implementing or enforcing clinical guideline standards. A database was developed to be used as an assessment tool and to standardize the documentation of achievement of outcomes. Feedback on the audit of the pharmaceutical care delivery and the database was received from the DCVR clinic pharmacist at a focus group meeting.
Micro RNA genes and their likely influence in rice (Oryza sativa L.) dynamic ...Open Access Research Paper
Micro RNAs (miRNAs) are small non-coding RNAs molecules having approximately 18-25 nucleotides, they are present in both plants and animals genomes. MiRNAs have diverse spatial expression patterns and regulate various developmental metabolisms, stress responses and other physiological processes. The dynamic gene expression playing major roles in phenotypic differences in organisms are believed to be controlled by miRNAs. Mutations in regions of regulatory factors, such as miRNA genes or transcription factors (TF) necessitated by dynamic environmental factors or pathogen infections, have tremendous effects on structure and expression of genes. The resultant novel gene products presents potential explanations for constant evolving desirable traits that have long been bred using conventional means, biotechnology or genetic engineering. Rice grain quality, yield, disease tolerance, climate-resilience and palatability properties are not exceptional to miRN Asmutations effects. There are new insights courtesy of high-throughput sequencing and improved proteomic techniques that organisms’ complexity and adaptations are highly contributed by miRNAs containing regulatory networks. This article aims to expound on how rice miRNAs could be driving evolution of traits and highlight the latest miRNA research progress. Moreover, the review accentuates miRNAs grey areas to be addressed and gives recommendations for further studies.
UNDERSTANDING WHAT GREEN WASHING IS!.pdfJulietMogola
Many companies today use green washing to lure the public into thinking they are conserving the environment but in real sense they are doing more harm. There have been such several cases from very big companies here in Kenya and also globally. This ranges from various sectors from manufacturing and goes to consumer products. Educating people on greenwashing will enable people to make better choices based on their analysis and not on what they see on marketing sites.
"Understanding the Carbon Cycle: Processes, Human Impacts, and Strategies for...MMariSelvam4
The carbon cycle is a critical component of Earth's environmental system, governing the movement and transformation of carbon through various reservoirs, including the atmosphere, oceans, soil, and living organisms. This complex cycle involves several key processes such as photosynthesis, respiration, decomposition, and carbon sequestration, each contributing to the regulation of carbon levels on the planet.
Human activities, particularly fossil fuel combustion and deforestation, have significantly altered the natural carbon cycle, leading to increased atmospheric carbon dioxide concentrations and driving climate change. Understanding the intricacies of the carbon cycle is essential for assessing the impacts of these changes and developing effective mitigation strategies.
By studying the carbon cycle, scientists can identify carbon sources and sinks, measure carbon fluxes, and predict future trends. This knowledge is crucial for crafting policies aimed at reducing carbon emissions, enhancing carbon storage, and promoting sustainable practices. The carbon cycle's interplay with climate systems, ecosystems, and human activities underscores its importance in maintaining a stable and healthy planet.
In-depth exploration of the carbon cycle reveals the delicate balance required to sustain life and the urgent need to address anthropogenic influences. Through research, education, and policy, we can work towards restoring equilibrium in the carbon cycle and ensuring a sustainable future for generations to come.
Characterization and the Kinetics of drying at the drying oven and with micro...Open Access Research Paper
The objective of this work is to contribute to valorization de Nephelium lappaceum by the characterization of kinetics of drying of seeds of Nephelium lappaceum. The seeds were dehydrated until a constant mass respectively in a drying oven and a microwawe oven. The temperatures and the powers of drying are respectively: 50, 60 and 70°C and 140, 280 and 420 W. The results show that the curves of drying of seeds of Nephelium lappaceum do not present a phase of constant kinetics. The coefficients of diffusion vary between 2.09.10-8 to 2.98. 10-8m-2/s in the interval of 50°C at 70°C and between 4.83×10-07 at 9.04×10-07 m-8/s for the powers going of 140 W with 420 W the relation between Arrhenius and a value of energy of activation of 16.49 kJ. mol-1 expressed the effect of the temperature on effective diffusivity.
Willie Nelson Net Worth: A Journey Through Music, Movies, and Business Venturesgreendigital
Willie Nelson is a name that resonates within the world of music and entertainment. Known for his unique voice, and masterful guitar skills. and an extraordinary career spanning several decades. Nelson has become a legend in the country music scene. But, his influence extends far beyond the realm of music. with ventures in acting, writing, activism, and business. This comprehensive article delves into Willie Nelson net worth. exploring the various facets of his career that have contributed to his large fortune.
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Introduction
Willie Nelson net worth is a testament to his enduring influence and success in many fields. Born on April 29, 1933, in Abbott, Texas. Nelson's journey from a humble beginning to becoming one of the most iconic figures in American music is nothing short of inspirational. His net worth, which estimated to be around $25 million as of 2024. reflects a career that is as diverse as it is prolific.
Early Life and Musical Beginnings
Humble Origins
Willie Hugh Nelson was born during the Great Depression. a time of significant economic hardship in the United States. Raised by his grandparents. Nelson found solace and inspiration in music from an early age. His grandmother taught him to play the guitar. setting the stage for what would become an illustrious career.
First Steps in Music
Nelson's initial foray into the music industry was fraught with challenges. He moved to Nashville, Tennessee, to pursue his dreams, but success did not come . Working as a songwriter, Nelson penned hits for other artists. which helped him gain a foothold in the competitive music scene. His songwriting skills contributed to his early earnings. laying the foundation for his net worth.
Rise to Stardom
Breakthrough Albums
The 1970s marked a turning point in Willie Nelson's career. His albums "Shotgun Willie" (1973), "Red Headed Stranger" (1975). and "Stardust" (1978) received critical acclaim and commercial success. These albums not only solidified his position in the country music genre. but also introduced his music to a broader audience. The success of these albums played a crucial role in boosting Willie Nelson net worth.
Iconic Songs
Willie Nelson net worth is also attributed to his extensive catalog of hit songs. Tracks like "Blue Eyes Crying in the Rain," "On the Road Again," and "Always on My Mind" have become timeless classics. These songs have not only earned Nelson large royalties but have also ensured his continued relevance in the music industry.
Acting and Film Career
Hollywood Ventures
In addition to his music career, Willie Nelson has also made a mark in Hollywood. His distinctive personality and on-screen presence have landed him roles in several films and television shows. Notable appearances include roles in "The Electric Horseman" (1979), "Honeysuckle Rose" (1980), and "Barbarosa" (1982). These acting gigs have added a significant amount to Willie Nelson net worth.
Television Appearances
Nelson's char
2. Chemical
Substances
Chemical contained
in products with
certain function
Raw Material,
Intermediate
What to be Regulated?
Pesticide
Animal Medicine
Pharmaceutical
Food
Food Additive
Radioactive
Substance
Military
Product
Cigarette
Industrial Chemicals
2
3. New Chemical Substance Notification
Registration of Hazardous Chemicals
Environmental Administration Registration of Hazardous Chemicals
License System
GHS, SDS and Labeling
3
4. New Chemical Substance Notification
Who Should Notify?
Scientific Research
Record
Simplified
Notification
Typical
Notification
No Data
Requirement
Special Type:
No Data
Requirement
Basic Type:
Minimal Data
Requirement
Data Requirement
increases with the
tonnage level
1 – 10
10 – 100
100 – 1000
>1000
MEP Order 7
Domestic Manufacturers
and Importers
Oversea Manufacturers and
Exporters
4
5. New Chemical Substance Notification
Basic Procedure Substance
Exempted? End
IECSC Listed? End
Notification Type
Typical Notification Scientific Research RecordSimplified Notification
Basic Special
Domestic
Eco/toxicolo
gical Data
Special
Condition
Statement
Data Gap Analysis
Carry out Tests
Dossier Submission
Authority Review
R&D Activity Carried
out
Certificate Issued
Supervision
Yes
Yes
No
No
v
Dossier Submission
Dossier Submission
5
6. New Chemical Substance Notification
Entering IECSC
1. Complete Typical Notification
2. A 5-year period required after first business
activity of the notified chemical substance
CIRS Data
Typical NotificationScientific Research RecordSimplified Notification
85200+1000+
6
7. New Chemical Substance Notification
Registration of Hazardous Chemicals
Environmental Administration Registration of Hazardous Chemicals
License System
GHS, SDS and Labeling
7
8. Registration of Hazardous Chemicals
What Chemical Needs to be Registered?
Chemicals listed on
the Catalog of
Hazardous Chemical
2015
Chemicals that
classified as hazardous
chemicals according to
SAWS Order 60
SAWS Order 53
Who Should Register?
Domestic Manufacturers
and Importers
8
9. Registration of Hazardous Chemicals
What Chemicals are Recommended to
be Identified?
Contain substances listed in
the HazChem Catalog, with
unknown hazard
Contain substances not listed
in the HazChem Catalog, with
unknown hazard
SAWS Order 60
Used for R&D or PPORD with
annual tonnage > 1 t/y, with
unknown hazard
Contain substances listed in
the HazChem Catalog, with
new hazard discovered
9
10. Registration of Hazardous Chemicals
Basic Procedure
Enterprises
Provincial Registration
Office
National Registration
Center
Document Submission
Provincial Review
passed
National Center
Review passed
Certificate
issued
Certificate
issued
Provincial Review
not passed
Rejected
Rejected
National Center
Review not passed
10
11. Registration of Hazardous Chemicals
A Few Points
1. Catalog of Hazardous Chemicals published
and implemented since May 1st 2015
2. No low-volume/specific usage exemption
3. Self-Classification accepted
4. 24 Hour Emergency Number required
5. SDS and Label required
11
12. New Chemical Substance Notification
Registration of Hazardous Chemicals
Environmental Administration Registration of Hazardous Chemicals
License System
GHS, SDS and Labeling
12
13. Environmental Administration Registration of Hazardous Chemicals
What Chemical Needs to be Registered?
Chemicals listed on
the Inventory of Toxic
Chemicals Restricted
from Import/Export
Chemicals listed on
the Catalog of
Hazardous Chemicals
2015 and List of PHCs
MEP Order 22
Who Should Register?
Importers and Exporters Manufacturers and Users
13
14. Environmental Administration Registration of Hazardous Chemicals
A Few Points
1. Chemicals listed in the List of PHCs require Risk
Assessment Report, Pollutant Release & Transfer
Registration (PRTR) form and Environmental Risk
Management Plan
2. No low-volume/specific usage exemption
14
15. New Chemical Substance Notification
Registration of Hazardous Chemicals
Environmental Administration Registration of Hazardous Chemicals
License System
GHS, SDS and Labeling
15
16. License System
What Type of License?
Production Safe Use Operation Transportation
What Should be Done?
SAWS Order 41 SAWS Order 57 SAWS Order 55
State Council
Decree 591
-Check the relevant chemical inventories
-Identify the activities: Production, Use, Operation,
Transportation
16
17. License System
Production
SAWS Order 41
Safe Production Licence
Before production initiated
Catalog of Hazardous Chemicals
Measures of Safe Production Licence
Industrial Goods Production Licence
Manufacturing enterprises
Catalog of Industrial Goods
Measures of Industrial Goods Production Licence
17
18. License System
Safe Use
SAWS Order 57
Safe Use Licence
Companies using hazardous chemicals for production
Catalog of Hazardous Chemicals
Exemption
Companies using hazardous chemicals as fuel
18
19. License System
Operation
SAWS Order 55
Operation Licence
Scope: Hazardous chemical operation and storage
Exemption
Companies selling hazardous chemical manufactured by
the same companies with the range of the factory
Companies with Port Operation Licence that runing
hazardous chemical storage
19
20. License System
Transportation
State Council
Decree 591
Transportation Licence
Road, Air and Waterway Transportation Licence
Related staffs with qualifications
Full time safety management staff for road air
and waterway transportation
Obligations
Compliant packaging, SDS and labels
Stabilizers and inhibitors disclosed
Appoint qualified transportation units
20
21. New Chemical Substance Notification
Registration of Hazardous Chemicals
Environmental Administration Registration of Hazardous Chemicals
License System
GHS, SDS and Labeling
21
22. GHS, SDS and Labeling
What Should be Provided?
Classification SDS Label
UN GHS Rev 4
16 Physical Hazards
10 Health Hazards
2 Environmental
Hazards
16 Sections
Language in
Simplified Chinese
24H Emergency
Telephone Number
All the required
label elements
Size requirement
GB 30000
GB/T 16483-2008
GB/T 17519-2013
GB 15258-2009
GB 190-2009
22
23. GHS, SDS and Labeling
A Few Points
1. CBI protection in SDS: components can be kept
confidential but hazards must be disclosed
2. Precautionary statement can be removed in
the simplified labels
CIRS Data
SDS of major countries
3000+ per year
23
25. Summary
Your Role in the Supply Chain
and Your Obligations
First Step: Check all the inventories
Inventory of Existing
Chemical Substance (IECSC)
Catalog of Hazardous
Chemical Substance (2015)
Priority Hazardous
Chemicals for Environmental
Management (PHCs)
List of Toxic Chemicals
Restricted to be
Imported/Exported
CCISS Inventory Search System by CIRS
cciss.cirs-group.com
25
29. Summary
Your Role in the Supply Chain
and Your Obligations
For chemicals NOT listed in IECSC
Roles in the supply Chain Obligations
Domestic Manufacturer New substance registration by MEP
Domestic Users
Implement proper precautionary measures when
using new chemicals after they are registered.
Foreign Manufacturers/ Suppliers
Appoint Chinese agent to register new substance
by MEP, or rely on Chinese importers to register
Domestic importers New substance registration by MEP
29
30. Summary
Your Role in the Supply Chain
and Your Obligations
For chemicals listed in Catalog of Hazardous Chemicals (2015)
Roles in the supply Chain Obligations
Domestic Manufacturer
Production License by SAWS;
Hazardous Chemical registration by NRCC-SWAS;
Environmental Administration Registration by MEP;
SDS/Label under China GHS
Domestic Users Environmental Administration Registration by MEP
Domestic Operators Operation License by SAWS
Domestic importers (users and traders) Hazardous Chemical registration by NRCC-SWAS;
Foreign Manufacturers/ Suppliers SDS/Label under China GHS
* If listed in PHCs, PRTR and Risk assessment report will be required 30
31. Summary
Your Role in the Supply Chain
and Your Obligations
For chemicals listed in List of Toxic Chemicals Restricted to be I/E
Roles in the supply Chain Obligations
Foreign exporter
Apply for Registration Certificate for the
Environmental Management on the Import of Toxic
Chemicals
Domestic importer Apply for Import Clearance Notification
Domestic exporter Apply for Export Clearance Notification
31
32. Summary
Your Role in the Supply Chain
and Your Obligations
For chemicals not listed in the Catalog (2015)
but with hazardous classifications
Roles in the supply Chain Obligations
Domestic Manufacturer
Hazardous Chemical registration by NRCC-SWAS;
SDS/Label under China GHS
Domestic importers (users and traders) Hazardous Chemical registration by NRCC-SWAS;
Foreign Manufacturers/ Suppliers SDS/Label under China GHS
32
34. Useful Links
1. Search Engine for Chemical Inventory in China:
http://cciss.cirs-group.com/
2. Regulatory Related Materials Download:
http://freedoc.cirs-group.com/en/
3. Regulatory News Updates:
http://www.cirs-reach.com
Find us on LinkedIn: https://www.linkedin.com/company/chemical-
inspection-and-regulation-service-limited?trk=biz-companies-cym
34
35. Our Services
Taiwan
- (Late) Pre-registration
- Existing substance registration
- New substance registration
- CCIP application
- Taiwan GHS
- Regulatory training
EU REACH
- Lead Registrant service
- Late Pre-registration
- REACH full registration
- EU CLP, SDS and Label
- CSR authoring
- Regulatory training
Korea
- Existing substance registration
- New substance registration
- Annual reporting
- Korean GHS
- Regulatory training
Global GHS
- EU CLP
- China, Japan, Korea, Taiwan
- US, Canada
- Malaysia, Thailand, Indonesia
- Others like Turkey, Brazil, Mexico, Russia,
Australia, New Zealand, etc.
35
Food and Food Related Products
- FCM Migration Tests
- Dietary Supplement Registration
- Diary Products Registration
- Ingredient and Package Review
- Dairy Product Label
- Genetically Modified Product Detection
Cosmetic
- SFDA Registration of Cosmetic
- New Cosmetic Ingredient Registration
- Toxicology Safety Assessment
- Product Formula and Label Review
- Cosmetic Notification in EU
- Customs Clearance Assistance
