The document discusses making the electronic health record (EHR) a "killer app" that accelerates widespread adoption. It argues that a paradigm shift is needed in EHR concepts, stakeholders, integration across domains, and faster adoption of technology. For the EHR to be a killer app, it must provide patient safety, efficient care, data management, knowledge management, and adaptive workflows. Overcoming challenges like standards, data sharing, and usability will help realize the promise of informatics to improve health globally.
This blog includes detailed information about how chatbot empowers healthcare ecosystem. It also encompasses data based insights of healthcare chatbot advantages and attributes of an effective Chatbot.
5 Powerful Real World Examples Of How AI Is Being Used In HealthcareBernard Marr
Healthcare can be transformed with the innovation and insights of artificial intelligence and machine learning. From robot-assisted surgery to virtual nursing assistants, diagnosing conditions, facilitating workflow and analyzing images, AI and machines can help improve outcomes for patients and lower costs for providers.
The Incredible Ways Artificial Intelligence Is Now Used In Mental HealthBernard Marr
The world is facing a mental health crisis. With a shortage of mental health professionals, individuals not seeking treatment due to lack of access or high costs, and a significant rise in mental health conditions, artificial intelligence (AI) tools are being assessed and used to create solutions to help support people’s mental health.
AI in Mental Health and Wellbeing - Current Applications and TrendsDaniel Faggella
This is a presentation I gave at TransTech 2018 in the Bay Area - drawing from our research on mental health AI startups (https://emerj.com/ai-sector-overviews/diagnosing-and-treating-depression-with-ai-ml/).
The full video of this presentation is available online:
https://www.youtube.com/watch?v=CvrqoPpYF94
How artificial intelligence(AI) will change the world in 2021kalyanit6
From smartphones to chatbots, Artificial intelligence is already pervasive in our digital lives. You may not know it yet. The moment behind AI is capturing, thanks to the huge amount of data that computers can collect every day about our likes, our purchases, and our movements. And experts in Artificial Intelligence Research to train or hate to learn how to train and ICT hint what we need to do to train machines.
This blog includes detailed information about how chatbot empowers healthcare ecosystem. It also encompasses data based insights of healthcare chatbot advantages and attributes of an effective Chatbot.
5 Powerful Real World Examples Of How AI Is Being Used In HealthcareBernard Marr
Healthcare can be transformed with the innovation and insights of artificial intelligence and machine learning. From robot-assisted surgery to virtual nursing assistants, diagnosing conditions, facilitating workflow and analyzing images, AI and machines can help improve outcomes for patients and lower costs for providers.
The Incredible Ways Artificial Intelligence Is Now Used In Mental HealthBernard Marr
The world is facing a mental health crisis. With a shortage of mental health professionals, individuals not seeking treatment due to lack of access or high costs, and a significant rise in mental health conditions, artificial intelligence (AI) tools are being assessed and used to create solutions to help support people’s mental health.
AI in Mental Health and Wellbeing - Current Applications and TrendsDaniel Faggella
This is a presentation I gave at TransTech 2018 in the Bay Area - drawing from our research on mental health AI startups (https://emerj.com/ai-sector-overviews/diagnosing-and-treating-depression-with-ai-ml/).
The full video of this presentation is available online:
https://www.youtube.com/watch?v=CvrqoPpYF94
How artificial intelligence(AI) will change the world in 2021kalyanit6
From smartphones to chatbots, Artificial intelligence is already pervasive in our digital lives. You may not know it yet. The moment behind AI is capturing, thanks to the huge amount of data that computers can collect every day about our likes, our purchases, and our movements. And experts in Artificial Intelligence Research to train or hate to learn how to train and ICT hint what we need to do to train machines.
Artificial intelligence in health care by Islam salama " Saimo#BoOm "Dr-Islam Salama
A Lecture about basics and concepts of Artificial Intelligence in health care & there applications
محاضرة عامة حول الذكاء الإصطناعي وأساسياته في الرعاية الصحية والطبية وتطبيقاته
Healthcare delivery is becoming an increasingly complex operation. Nurses, physicians and other allied healthcare professionals are increasingly measured on their quality of work, even with increasing patient volume and patient complexity. Technology, from sensors to analytics to software based decision support and automation, have the potential to both leverage our healthcare provider workforce to mange increasing demands and to improve quality. This presentation will focus on the key areas of opportunity for technology to improve the capabilities of healthcare providers in delivering quality care.
Artificial Intelligence in the Hospital SettingDaniel Faggella
This presentation was given at the AI Applications Summit (an event for healthcare and pharma professionals) in December 2017. The presentation itself covers to current traction of artificial intelligence in the hospital setting, as well as the unique challenges of applying AI in healthcare (including compliance, resistance from some doctors, the "black box" problem of machine learning, and more). Includes references to Machine Learning in Healthcare Executive Consensus: https://www.techemergence.com/machine-learning-in-healthcare-executive-consensus/
Bio IT World 2019 - AI For Healthcare - Simon Taylor, LucidworksLucidworks
Presentation from Bio IT World, Boston | April 16-18, 2019
Track: AI for Healthcare: Practical Application of AI in Clinical Healthcare
Session Title: To AI or Not to AI, That Is the Question
Speaker: Simon Taylor, Lucidworks
Artificial Intelligence and Machine Learning are transforming the work of human labor. Healthcare professionals will see their work transformed and augmented with this technology, but the manner in which these changes will occur is nuanced. In this presentation, I will explore the manner in which the labor of healthcare will be transformed, review evidence to support this prediction, and remark on the changes already underway.
Artificial intelligence (AI) is already transforming healthcare. It's an invaluable tool, capable of storing and processing vast amounts of data almost simultaneously. AI allows for rapid and accurate diagnosis, early detection, advanced research and much more.
AI in Healthcare: From Hype to Impact (updated)Mei Chen, PhD
The primary goal of this workshop is to help health professionals gain a critical understanding of the various types of AI technologies available so they can make wise decisions and invest AI for healthcare improvement.
ON EXPLOITING MULTIMODAL INFORMATION FOR MACHINE INTELLIGENCE AND NATURAL IN...Amit Sheth
Keynote: SECOND INTERNATIONAL WORKSHOP IN MULTIMEDIA PRAGMATICSMMPrag 2019, San Jose, California, 28-30 March 2019
http://mipr.sigappfr.org/19/keynote-speakers/
The Holy Grail of machine intelligence is the ability to mimic the human brain. In computing, we have created silos in dealing with each modality (text/language processing, speech processing,image processing, video processing, etc.). However, the human brain’s cognitive and perceptual capability to seamlessly consume (listen and see) and communicate (writing/typing, voice, gesture) multimodal (text, image, video, etc.) information challenges the machine intelligence research. Emerging chatbots for demanding health applications present the requirements for these capabilities. To support the corresponding data analysis and reasoning needs, we have to explore a pedagogical framework consisting of semantic computing, cognitive computing, and perceptual computing (http://bit.ly/w-SCP). In particular, we have been motivated by the brain’s amazing perceptive power that abstracts massive amounts of multimodal data by filtering and processing them into a few concepts (representable by a few bits) to act upon. From the information processing perspective, this requires moving from syntactic and semantic big data processing to actionable information that can be weaved naturally into human activities and experience (http://bit.ly/w-CHE). Exploration of the above research agenda, including powerful use cases, is afforded in a growing number of emerging technologies and their applications - such as chatbots and robotics. In this talk, I will provide these examples and share the early progress we have made towards building health chatbots (http://bit.ly/H-Chatbot) that consume contextually relevant multimodal data and support different forms/modalities of interactions to achieve various alternatives for digital health (http://bit.ly/k-APH). I will also discuss the indispensable role of domain knowledge and personalization using domain and personalized knowledge graphs as part of various reasoning and learning techniques.
Support for the keynote "Data, Ethics and Health Care,”, Keynote, Creating Value in Health Care through Innovation Management, May 16,2019, Deusto, San Sebastien
The latest AI advances have the potential to massively improve our health and well being. In this talk, we will explore the most important opportunities for AI in healthcare. For example, we will explore how AI can diagnose major life-threatening conditions even before those conditions emerge. We will talk about AI's ability to recommend dramatically more effective and less harmful treatment plans based on AI's understanding of a patient's medical history and current conditions. Finally, we will talk about role of AI in making our healthcare system effective and affordable for everyone. In each part of this presentation, we will look at specific examples of how AI is used to address the COVID-19 pandemic.
Short overview over possibilities and challenges of using artificial intelligence in health care. Presentation from the MultiHelix ThinkTank, May 14 2020.
Artificial intelligence in health care by Islam salama " Saimo#BoOm "Dr-Islam Salama
A Lecture about basics and concepts of Artificial Intelligence in health care & there applications
محاضرة عامة حول الذكاء الإصطناعي وأساسياته في الرعاية الصحية والطبية وتطبيقاته
Healthcare delivery is becoming an increasingly complex operation. Nurses, physicians and other allied healthcare professionals are increasingly measured on their quality of work, even with increasing patient volume and patient complexity. Technology, from sensors to analytics to software based decision support and automation, have the potential to both leverage our healthcare provider workforce to mange increasing demands and to improve quality. This presentation will focus on the key areas of opportunity for technology to improve the capabilities of healthcare providers in delivering quality care.
Artificial Intelligence in the Hospital SettingDaniel Faggella
This presentation was given at the AI Applications Summit (an event for healthcare and pharma professionals) in December 2017. The presentation itself covers to current traction of artificial intelligence in the hospital setting, as well as the unique challenges of applying AI in healthcare (including compliance, resistance from some doctors, the "black box" problem of machine learning, and more). Includes references to Machine Learning in Healthcare Executive Consensus: https://www.techemergence.com/machine-learning-in-healthcare-executive-consensus/
Bio IT World 2019 - AI For Healthcare - Simon Taylor, LucidworksLucidworks
Presentation from Bio IT World, Boston | April 16-18, 2019
Track: AI for Healthcare: Practical Application of AI in Clinical Healthcare
Session Title: To AI or Not to AI, That Is the Question
Speaker: Simon Taylor, Lucidworks
Artificial Intelligence and Machine Learning are transforming the work of human labor. Healthcare professionals will see their work transformed and augmented with this technology, but the manner in which these changes will occur is nuanced. In this presentation, I will explore the manner in which the labor of healthcare will be transformed, review evidence to support this prediction, and remark on the changes already underway.
Artificial intelligence (AI) is already transforming healthcare. It's an invaluable tool, capable of storing and processing vast amounts of data almost simultaneously. AI allows for rapid and accurate diagnosis, early detection, advanced research and much more.
AI in Healthcare: From Hype to Impact (updated)Mei Chen, PhD
The primary goal of this workshop is to help health professionals gain a critical understanding of the various types of AI technologies available so they can make wise decisions and invest AI for healthcare improvement.
ON EXPLOITING MULTIMODAL INFORMATION FOR MACHINE INTELLIGENCE AND NATURAL IN...Amit Sheth
Keynote: SECOND INTERNATIONAL WORKSHOP IN MULTIMEDIA PRAGMATICSMMPrag 2019, San Jose, California, 28-30 March 2019
http://mipr.sigappfr.org/19/keynote-speakers/
The Holy Grail of machine intelligence is the ability to mimic the human brain. In computing, we have created silos in dealing with each modality (text/language processing, speech processing,image processing, video processing, etc.). However, the human brain’s cognitive and perceptual capability to seamlessly consume (listen and see) and communicate (writing/typing, voice, gesture) multimodal (text, image, video, etc.) information challenges the machine intelligence research. Emerging chatbots for demanding health applications present the requirements for these capabilities. To support the corresponding data analysis and reasoning needs, we have to explore a pedagogical framework consisting of semantic computing, cognitive computing, and perceptual computing (http://bit.ly/w-SCP). In particular, we have been motivated by the brain’s amazing perceptive power that abstracts massive amounts of multimodal data by filtering and processing them into a few concepts (representable by a few bits) to act upon. From the information processing perspective, this requires moving from syntactic and semantic big data processing to actionable information that can be weaved naturally into human activities and experience (http://bit.ly/w-CHE). Exploration of the above research agenda, including powerful use cases, is afforded in a growing number of emerging technologies and their applications - such as chatbots and robotics. In this talk, I will provide these examples and share the early progress we have made towards building health chatbots (http://bit.ly/H-Chatbot) that consume contextually relevant multimodal data and support different forms/modalities of interactions to achieve various alternatives for digital health (http://bit.ly/k-APH). I will also discuss the indispensable role of domain knowledge and personalization using domain and personalized knowledge graphs as part of various reasoning and learning techniques.
Support for the keynote "Data, Ethics and Health Care,”, Keynote, Creating Value in Health Care through Innovation Management, May 16,2019, Deusto, San Sebastien
The latest AI advances have the potential to massively improve our health and well being. In this talk, we will explore the most important opportunities for AI in healthcare. For example, we will explore how AI can diagnose major life-threatening conditions even before those conditions emerge. We will talk about AI's ability to recommend dramatically more effective and less harmful treatment plans based on AI's understanding of a patient's medical history and current conditions. Finally, we will talk about role of AI in making our healthcare system effective and affordable for everyone. In each part of this presentation, we will look at specific examples of how AI is used to address the COVID-19 pandemic.
Short overview over possibilities and challenges of using artificial intelligence in health care. Presentation from the MultiHelix ThinkTank, May 14 2020.
Full-day workshop held by Fabio Sergio and Thomas Sutton on November 30 2009 at the Mobile Healthcare Industry Summit, in London (www.mobilehealthcareindustrysummit.com).
"How can your organization make the most of the emerging opportunities presented by mobile healthcare?
How do you design successful m-Health solutions?
In this full-day workshop, frog design will help you answer these questions and provide you with a toolkit to drive your company's m-Health strategy."
Analysis of business models for mobile healthcare with example applications. Delivered at the Mobile Healthcare industry summit London December 2009.
Summary:
Emerging business models for Mobil Health Applications.The mobile handset will be the central delivery platform. Handset manufacturers, and Network operators have limited direct revenue opportunity from mobile health applications.
Successful strategies must therefore focus on creating an attractive ecosystem for mobile health. Generating user value will bring corporate revenue.
EHRs, PHRs, EMRs: Making Sense of the Alphabet SoupCHI*Atlanta
CHI*Atlanta's October program tackles health records and the potential of user experience to improve their adoption. Panelists include CDC, Kaiser Permanente, and Greenway Technologies. Hosted at Philips Design to cover public, private, and vendor perspectives.
Precision and Participatory Medicine - Medinfo 2015 Panel on big data. Includes the proposal to use the term Expotype to characterise the Exposome of an individual. Electronic expo typing would refer to the automatic construction of individual expo types from electronic clinical records and other sources of environmental risk factor and exposure data.
Sdal air health and social development (jan. 27, 2014) finalkimlyman
The American Institutes for Research (AIR) and Virginia Tech are collaborating to explore and develop new approaches to combining, manipulating and understanding big data. The two are also looking at how big data analytics can help answer questions critical to solving issues in education, workforce, health, and human and social development. They held two workshops on January 7 and 27, 2014- the first on Education and Workforce Analytics and the second on Health and Social Development Analytics.
Robyn Whittaker
Clinical Trials Research Unit, University of Auckland
(Friday, 10.30, Telehealth/mHealth)
mHealth or mobile health describes the use of mobile communications devices for health-related purposes. There is much interest in mHealth internationally at this time; including interest in interventions developed in New Zealand/by New Zealanders. A recent research project examined the key issues in the implementation of mHealth and the current opportunities to address those issues in the U.S. The key mHealth issues are outlined here under the themes of policy and regulation, the wireless environment, the health system, current mHealth initiatives in practice and research. This paper examines how these issues may apply in New Zealand and the current opportunities to address them. This information may be useful to those embarking on mHealth developments in New Zealand and may help to inform the inclusion of mobile capabilities within the NZ Health IT infrastructure.
Cette conférence - e-santé : évolution ou révolution? - a pour but de présenter quelques projets développés par les hautes écoles et entreprises de pointe dans le domaine. A cette occasion, Prof. Dr. Henning Müller a fait un exposé intitulé: La e-santé en général et quelques projets de la HES-SO Valais.
Trusted! Quest for data-driven and fair health solutions Sitra / Hyvinvointi
An inspiring online event on 3 February 2021. We are discussing the future of data-driven health solutions that focus on fairness for all stakeholders: people, business and the public sector. We are asking questions such as: What is fairness in health? What role does trust play in data-driven health services? What needs to change and who needs to act? Most of all, we are launching “The Fair Health Data Challenge“.
Event speakers:
- Jaana Sinipuro, Project Director, IHAN – Human-driven data economy, Sitra
- Dipak Kalra, President, The European Institute for Innovation through Health Data (i~HD)
- Pekka Kahri, Technology Officer, HUS Helsinki University Hospital
- Markus Kalliola, Project Director, Health data 2030, Sitra
- Tiina Härkönen, Leading Specialist, Sitra
Mobile health is an ever expanding field, and shows great promise for delivering care to remote patients. In this presentation at the ATA 2012 conference, Dr. Robert Ciulla demonstrates the potential for mHealth to improve care availability and how T2 is supporting that goal.
Information+Integration ? Innovation an HL7/EFMI/HIMSS @eHealthweek2015 in Rigachronaki
Join us to explore “Interoperability in action: information + integration = innovation?” and engage in lively debate on how rethinking interoperability standards and continuing education can bridge divides, change cultures, and open markets!
Perspectives from health management, industry, government, health education, and standardization exemplify challenges and opportunities for liberation of data that can drive desired social and technological innovation.
This is a call for action to explore how the partnership of HL7, EFMI and HIMSS can catalyze the equation “information + integration = innovation” to bridge divides, change culture and open markets.
> Definition of RWD
> RWD - Big Data Characteristics
> Sources of RWD
> Important Stakeholders
> Benefits of RWD
> Why Data Sharing is Important?
> Benefits of Data Sharing
> Who Benefits?
> Ultimate Goals
> Case Studies
> Challenges
> Data Privacy Scenario
> Data Security in India
> Regulatory Perspectives Around RWD
> How to Encourage Data Sharing?
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
1. EHR – The Killer App?
HINZ
Bringing the Electronic Health Record to Life
21 June 2012
W. Ed Hammond. Ph.D., FACMI, FAIMBE, FIMIA, FHL7
Director, Duke Center for Health Informatics
Director, Applied Informatics Research, DHTS
Associate Director, Biomedical Informatics Core, DTMI
Professor, Department of Community and Family Medicine
Professor Emeritus, Department of Biomedical Engineering
Adjunct Professor, Fuqua School of Business
Duke University
Chair Emeritus, HL7
2
2. What is a killer app?
An application that
accelerates the adoption
and ubiquitous use of the
application.
3
3. Killer apps
• Personal computer
• World-wide web
• Wireless networks
• Google, Facebook, Social
Networking
4
4. What needs to happen to
make the EHR a killer app?
• Paradigm shift required in
– Concept of EHR/EHRS
– Recognition of all the stakeholders
– Roles of stakeholders
– Integration across all domains relating to
health and healthcare
– Creating common language
– Relationship between venders and users
5
5. What needs to happen …
• Greater, quicker and appropriate use of
available technology
• Adopting more quickly to change
• Faster creation and more effective use of
required resources: applications,
standards, workforce
• Sharing data, knowledge, and processes
– Cooperative competition
• Stitch together current silos
6
6. Technology Advances
• Mobile devices
– iPad and similar devices
– Personal health devices
• Ubiquitous wireless
• Voice recognition – still coming but useful
• Virtual reality – IBM’s Watson
• Cloud computing
• RFID
7
7. From molecules to population
Molecular Clinical Patient Public Population
Biology Research Care Health Health
Individual, Family, Community, Societies
Site of Care: Intensive care, inpatient, ambulatory,
emergency department, long term care, home care
Clinical Specialties
Global
8
8. Components of communication
• Data
– Semantically interoperable, high quality, timely
• Knowledge
– Appropriate, accessible, comprehensive
• Information
– Actionable, focused, clear, reduces uncertainty
• Judgment
– Human input based on experience and observation;
an intangible component
• Wisdom
– Individuals trained in how to use data, knowledge,
and information
9
9. Application of HIT
Understand Outcome
Understand the Understand measurements Implement
problem to be causes, factors, and data proposed
solved. issues required to solution.
monitor & solve
Evaluate
outcome
Feedback Loop
Articulate health IT problems with the
precision of a scientific hypothesis.
10
10. The Spectrum of Problem
Solving
• Science base of biology and medicine
• Collection and interpretation of signals
• Multiple (re-use) of data
• Application of science and data in clinical
care
• Extension of clinical care to populations
11
11. Application Areas
• Genetics
– Genomics, proteomics, metabolomics, biomarkers, biomedical
modeling…
• Clinical Research
• Clinical systems (HIS, CPOE, ePrescribing, CDW, …)
– Clinical domain systems (cardiology, oncology, ,,,)
– Electronic Health Records
• EHR, EMR, PHR, Regional, National, Population
• Public Health
• Telemedicine
– Mobile and personal medical devices
• Educational Tools
12
12. Genetics
• Gene mutation will identify many treatable genes
such as Hirschsprung’s disease, muscular
dystrophy, and cystic fibrosis
• Drug treatments are already influenced by
genomic information
– The anticoagulant drug warfarin has a narrow
therapeutic window - too high a dose, patient can
bleed to death; too low a dose, clots remain unclotted.
Genetic information [certain versions of two genes
CYP2C9 and VKORC1] are highly predictive of rate of
metabolizing warfarin.
13
13. New Associations
• EHR must include genetic information
– Biomarkers need to be included in EHR with
meaning and actions included in an
accompanying knowledge base
– Gene mutations need to be included with links
to meaning and actions including in an
accompanying knowledge base
– Phenotype sets need to be linked to a disease
14
14. Resulting Behavior Changes
• Physicians need not become geneticists.
Computers will use associated knowledge
to suggest actions based on biomarkers,
gene data, and phenotypes
• Physicians will become the “action arm”
with computers being the “thinking arm”
• Physicians role is as a participating
service
15
15. Changing demands
• Aging population, world wide. In U.S., a
citizen becomes 65 years old every 6
seconds. Over the next 30 years, we will
add 20 million persons to the over 65
category.
• Current health care systems cannot
handle this volume.
• The role of primary care giver role will be
shared with less trained persons.
16
16. Changing role of patients
• Increased participation and responsibility
for one’s own health
• Requires new methods of education,
monitoring, networking, data access
– Personal Health Records and patient portals
• Addressing health disparities
• Treating social and environment and
cultural issues
17
17. A killer app delivers …
• Patient safety
• Efficient and effective health care delivery
• Health surveillance, bio-defense and natural
disaster health data management
• Real quality, reduced uncertainty, trust
• Cost containment in face of increasing costs of
healthcare
• Accommodation of an aging and mobile
population
• Effective management of chronic disease
• Higher quality of life as well as longevity
18
18. A killer app delivers …
• Equal access to care
• Consumer sophistication and knowledge in health;
mobility
• Increasing continuous uses of data – translational
medicine
• Changes in doctor’s information gathering skills
• Increase in options for testing and treatment
• Limited connectivity among providers with multiple
providers involved in care
• The Healthcare Gamble – who calls the play?
19
19. A killer app delivers …
• Practice of medicine that is predictive, personalized,
pre-emptive, and participatory [the 4Ps]
• Accommodating increasing limitations of resources:
– Decreasing number of providers
– Smaller hospitals disappearing
– Long waits for appointments
– Few walk-in appointments available
• Changing models for healthcare
– Consumer driven health care
– Health savings accounts
– Shopping mall clinics, Doc in Box clinics
– Wal-Mart, Google and Microsoft movement into healthcare
20
20. A killer app accommodates …
• Volume of data about a patient has increased
tremendously over the past decades
– Increasing number of diagnostic tests
– Increasing numbers and modality of images
– Genetic testing
– Access to data at place and time of decision making is
critical
– Informed decision requires data
– Data must be used for multiple purposes
– From bytes to kilobytes to megabytes to gigabytes to
terabytes to petabytes to exabytes to zettabytes to …
21
21. A killer app accommodates …
• Sources and amount of knowledge have
increased exponentially over the past decades
• NLM indexes over 1 million documents each
year
• Undergraduate and graduate education is
based on out-of-date concepts
• Continuing medical education is inadequate
• We can’t learn fast enough to be effective
• New knowledge requires new skills and new
understanding
22
22. Killer app EHR provides …
• Data and data management
– The right data and only the right data
– Complete, aggregated, timely, trustworthy, unambiguous,
reusable, logically accessible
– Event driven displays, logically driven
• Knowledge and knowledge management
– Evidence-based, up-to-date, appropriate, integrated into work
flow, human and computer useable
• Processes and work flow
– Effectively and efficiently combines data with knowledge to
enable optimum human decision-making
– Monitor decisions and outcomes and provide safety checks,
feedback and recommendations
– Integrate data collection, presentation and decision support
transparently into care delivery process
23
23. Requires paradigm shifts
• Technologists – more appropriate use of technology;
understanding the problems that need to be solved; better
coupling with the clinical community
• Clinical community – recognize what technology can do to
significantly enhance health care; become the drivers for the
use of eHealth; understand value of team approach that
includes the patient
• Patient – Accept responsibility for one’s own health; become
engaged in decision-making related to one’s own health;
enhanced awareness of personal risk factors; practice
prevention
24
24. EHR – The Centerpiece of HIT
Data Creation
EHR
Data Collection The Enablement
Patient Care
Data Interchange
Data Aggregation Personalized Care
Community Care
Public Health
Includes the service Proactive interpretation
Real-time integration of of data to direct behavior
functions:
knowledge to direct and to enable quality care.
HIS, CPOE, CDS, e
control collection of data.
Prescribing, billing
25
25. Enabling Better Health
EHR systems must be adaptive. We need to be
able to include any new data element (self-
defined) without additional programming.
Exchange of data should be driven by filters or a
defined set of business rules based on data
elements.
Systems should use Enterprise Architecture
(SOA) approach in order to accommodate new
functionalities and new technologies.
26
26. Possible Scenario
Knowledge Database
Institutional Clinical
Data Data Data Data Mining
Repository Warehouse
Push, pull or query based
Service
The
Filter
Applications National
(CPOE, ePres Patient-centric
Linkage
cribing, etc.) Essential EHR
Other Contained
systems in Regional
HIE
27
27. EHR
• Architecture of EHR must support at variety of
uses.
– Requires independence of data from data
collection and application set
• Data must be interoperable; it must be
automatically reusable, capable of continuous
use
• It must be capable of integrating with new data
to produce new value and understanding.
• Granularity of data must start at lowest levels to
permit effective computer analyses and
understanding
• Reevaluate patient care and treatment as new
28
data enters incorporating old data
28. EHR Issues
• Usability is key – minimize keystrokes for input
and query
• Every user, regardless of level, must understand
the value of the data
• Think ahead of user – alert fatigue can be
avoided by walking behind when appropriate
and alert only what is important
• Capture data from least expensive source but
maintain quality
29
29. EHR Issues
• Free text is necessary as modifiers but attached
to structure
• Cognitive support provides intelligent interaction
with content
• Is an active partner with human in awareness,
evaluation and decision making
• Supports push, pull, interactive queries,
packaged queries, event-based queries
30
30. Challenges
• Privacy issues; recognize that personal control of
data may harm creation of new knowledge and
seamlessly connecting the contributing domains for
the most effective care
• Identification and implementation of standards for
data and data exchange
• Controlled and purposeful exchange of data
• Quality of data is insured through process,
algorithms, and certainty factor
• Addresses provenance
31
31. Match Computational Approach to
Complexity of Data
Automation
Evidence-
based
Work lists advisors
Decision
Connectivity Support
Disease
Aggregate
Stead WW. Electronic Health management
EHR
Records. In: Rouse
WB, Cortese DA, eds.
dashboards
Engineering the system of
healthcare delivery.
Tennenbaum Institute Series
on Enterprise Systems, Vol. 3.
Amsterdam: IOS Press; 2009.
Data Mining
32. U.S. Focus
• HIE and interoperability (probably the #1
discussion issue in the town-hall session)
• Usability
• Vendor relations and vendor accountability
• Need for reimbursement reform before
providers will benefit from HIT
• Data sharing, as well as privacy, consent,
and cases of breach
33
33. U.S. Focus
• Stories of successful overhead reduction
• Use of more “scientific methods” of
research and testing to determine future
mandates, such as Meaningful Use,
Phase 3
• Patient buy-in and collaboration
34
34. Informatics
• Within Informatics is the power to bridge
existing silos and significantly advance
health, longevity and quality of life for all
citizens of the world.
• This achievement can only happen through
the global community acting together, sharing
costs and responsibility.
• The inequalities of the world, the globally
growing aging population, and economics
demand this action be taken.
35
35. Conclusion / Summary
• The pace of technology has been paced
by Moore’s law: roughly, computational
power doubles approximately every two
years
• Use of technology – informatics – has not
kept pace. The future of health care
depends on our getting ahead of the curve
• That step demands a step change –
revolution, not evolution!
36
36. The Final Word
• Informatics and HIT holds the promise for a
better world.
• Limited resources requires working together and
sharing everything.
• We must speak the same language with the
same meaning.
• Connectivity and communication is essential.
• Leadership and commitment of governments are
a necessity.
• Will the EHR become the killer app in our
lifetime? 37