This document discusses pre-eclampsia, a disease of pregnancy characterized by high blood pressure (BP 140/90 or more) developing after 20 weeks of gestation in a previously normotensive woman. Pre-eclampsia can progress to eclampsia, which involves seizures. Risk factors include primigravida, age, past history, and socioeconomic status. Symptoms may include headache, visual disturbances, epigastric pain, and edema. Diagnosis is based on elevated blood pressure readings taken twice over six hours. Management involves delivering the baby to terminate the pregnancy, administering magnesium sulfate to prevent seizures, and controlling blood pressure. Complications can include maternal and fetal consequences such as renal failure, stroke,
Please find the power point on Management of Preterm labor. I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Please find the power point on Management of Preterm labor. I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Please find the power point on Vacuum delivery. I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
A brief introduction regarding oxytocics & tocolytics which are the indispensable drugs in obstetrics. It consists of illustrative images, classification of drugs with their dosage, uses & side-effects along with contraindications
Please find the power point on Vacuum delivery. I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
A brief introduction regarding oxytocics & tocolytics which are the indispensable drugs in obstetrics. It consists of illustrative images, classification of drugs with their dosage, uses & side-effects along with contraindications
Toxemia of pregnancy: Definition,risk factors,Clinical features,management of pre-eclampsia. Nursing students will understand toxemia of pregnancy .Jasleen Kaur
Prof. Mridul Panditrao's Peri-operative Management of Jehovah's Witness Patient Prof. Mridul Panditrao
A case report of Emergency Peri-operative Mnagement of a Jehovah's Witness patient.
Because of their peculear religious belief, these patients do not accept Blood and It's products. This can pose serious problems to the Anesthesiologist.
Pregnancy induced hypertension introduction
Classification of pregnancy induced hypertension
Preeclampsia -
Definition
Criteria for diagnosis of preeclampsia,
Epidemiology of preeclampsia,
Risk factors of preeclampsia,
Pathogenesis of preeclampsia,
Pathophysiology of preeclampsia,
Course of preeclampsia,
Complications of preeclampsia,
What is HELLP ?
Management of preeclampsia at home, at hospital, during labour, during puerperium,
Management of acute fulminant preeclampsia
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
2. Pre- eclampsiaPre- eclampsia ImpendingImpending EclampsiaEclampsia
It is a disease of pregnancy characterized byIt is a disease of pregnancy characterized by
• BP 140/ 90 or more.BP 140/ 90 or more.
• After 20 week gestational age.After 20 week gestational age.
• In previous normotensive pt.In previous normotensive pt.
• Reading taken twice at interval 6 hours.Reading taken twice at interval 6 hours.
•Exclude other causes of 2.ry hypertensionExclude other causes of 2.ry hypertension
(ACDEPR)(ACDEPR)
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4. DBP110 or moreDBP110 or more
Increase in SBP by 30 mmHgIncrease in SBP by 30 mmHg
Increase in DBP by 15mmHgIncrease in DBP by 15mmHg
2 read of MABP 105 or more OR increase by 202 read of MABP 105 or more OR increase by 20
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But diagnosis can be by:But diagnosis can be by:
This condition is associated with significantThis condition is associated with significant
protienuriaprotienuria
5. ??????
Not related to the fetus or uterusNot related to the fetus or uterus
Failure of placentationFailure of placentation
Abnormal lipid metabolismAbnormal lipid metabolism
Decrease CaDecrease Ca++++
in dietin diet
All pathogenesis due to vasospasm & endothelial dysfunction
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Aetiology:Aetiology:
6. Risk facctors:
Primigravida
age
Past history
Change the husband
Condition in which
placenta enlarge
Pre-existing disease
Low socioeconomic
Risk factor decrease :
Smokers
Prolong exposure to
paternal antigen
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8. INCIDENCE & EPIDEMIOLOGYINCIDENCE & EPIDEMIOLOGY
Occur in 5-10% pregnancyOccur in 5-10% pregnancy
Death about 2% in UKDeath about 2% in UK
Death increase in Eclampsia which occur inDeath increase in Eclampsia which occur in
intrapartum &post partum due to:intrapartum &post partum due to:
-Relax of observation during these period-Relax of observation during these period
-Increase in release of pathogenic factor-Increase in release of pathogenic factor
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9. PRE-ECLAMPSIAPRE-ECLAMPSIA
Symptoms:Symptoms: may bemay be
AsymptomaticAsymptomatic
HeadacheHeadache
Visual disturbanceVisual disturbance
Epigastric painEpigastric pain
oedemaoedema
Sign:Sign: may bemay be
High BPHigh BP
Fluid retensionFluid retension
Brisk reflexsBrisk reflexs
Fundel level less thanFundel level less than
datedate
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12. CLINICAL FEATURECLINICAL FEATURE
it is grand mal convulsion which pass throughit is grand mal convulsion which pass through
stages of:stages of:
1.1. Tonic contractionTonic contraction
2.2. ClonicClonic
3.3. ComaComa
Usually take about 60-90 seconds.Usually take about 60-90 seconds.
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13. EDEN’S CRITERIA OF SEVERITYEDEN’S CRITERIA OF SEVERITY
Coma take 6 hours or moreComa take 6 hours or more
SBP reach 200 mmHgSBP reach 200 mmHg
Tm 39 or moreTm 39 or more
Pulse rate 120/minPulse rate 120/min
RR 40/minRR 40/min
2 fits or more2 fits or more
All this can end in maternal brain deathAll this can end in maternal brain death
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15. MANAGMENTSMANAGMENTS
Aim of it :Aim of it :
1-maintain patent airways1-maintain patent airways
2-prevents the fits2-prevents the fits
3-terminate the pregnancy3-terminate the pregnancy
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16. 1.1. Usually unnecessary to try to stop the initialUsually unnecessary to try to stop the initial
convulsion which usually last about 60-90convulsion which usually last about 60-90
secondsseconds
2.2. IV Diazepam slowly 5mg over 1 minIV Diazepam slowly 5mg over 1 min
3.3. 3. Roll the patient on his left side to avoid3. Roll the patient on his left side to avoid
maternal injurymaternal injury
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17. 4. Apply Suction to the secretion from her mouth4. Apply Suction to the secretion from her mouth
5. Adequate Oxygen should be maintained by face5. Adequate Oxygen should be maintained by face
mask & airways to prevent swallowing of tonguemask & airways to prevent swallowing of tongue
6. Prevent further convulsions by MgSO6. Prevent further convulsions by MgSO44 by IVby IV
bolus of 4 – 6 g over 15 min. If convulsion recurbolus of 4 – 6 g over 15 min. If convulsion recur
further bolus of 2g.further bolus of 2g.
7. Acidosis should be corrected if necessary by IV7. Acidosis should be corrected if necessary by IV
NaHCONaHCO33
8. SBP 170 mmHg or more, DBP 110 mmHg is risk8. SBP 170 mmHg or more, DBP 110 mmHg is risk
factor for CVA so should be lowered by eitherfactor for CVA so should be lowered by either
Nifedipine 10 – 20 mg SL. Or Hydrallazine 5mgNifedipine 10 – 20 mg SL. Or Hydrallazine 5mg
followed by infusion.followed by infusion.
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19. 1.Assessment of state of fetus (U/S,1.Assessment of state of fetus (U/S,
Doppler CTG)Doppler CTG)
2.either : - Deliver the baby regardless2.either : - Deliver the baby regardless
of the gestational ageof the gestational age
intense monitoring maternal health inintense monitoring maternal health in
hope of improvement fetalhope of improvement fetal
outcome by increase gestationaloutcome by increase gestational
age.age.
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20. It is attention to fluid balance , BP , RenalIt is attention to fluid balance , BP , Renal
& Hepatic function & CNS& Hepatic function & CNS
1.More aggressive control of BP1.More aggressive control of BP
2.MgSO2.MgSO44 maintained for 48 hrs at 1g/hr ivmaintained for 48 hrs at 1g/hr iv
3.Subcutaneous heparin prophylaxis3.Subcutaneous heparin prophylaxis
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21. 2.permanent CNS damage2.permanent CNS damage
3.Intracranial haemorrhage3.Intracranial haemorrhage
4.Renal failure4.Renal failure
5.Death5.Death
1.During the fit1.During the fit
tounge bittingtounge bitting
head traumahead trauma
bone #bone #
AspirationAspiration
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