This document summarizes a study investigating the seismic response of CO2 plumes in a heterogeneous sandstone reservoir under different fluid saturation conditions. The study uses geological modeling of a potential CO2 storage site to generate fluid flow simulations of CO2 injection. Rock physics models are used to predict elastic properties under uniform and patchy CO2 saturation assumptions. Forward seismic modeling is then used to compare the seismic detectability of trapped CO2 accumulations and migrating plume fronts under the different saturation scenarios. The results indicate patchy saturation leads to easier detection of accumulations but more subtle amplitude changes, while migrating fronts are very difficult to detect. Factors like saturation distribution, heterogeneity, and site conditions are found to influence CO2 plume