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Development and Supportive Care (DSC)
Foundation for Newborn & Children (India)
B - 106, Chitranjan Park, New Delhi - 110 019, India
Email: amit19762000@yahoo.com, dscnicupeds@gmail.com
3rd
Edition, November, 2019
Principles and Practices of
Developmentally Supportive Care (DSC)
in the NICU
& Clinical Applications
in Neonatal Medicine
Chief Scientific Editor
Dr Amitava Sengupta
i
Principles and Practices of
Developmentally Supportive Care (DSC)
in the NICU &
Clinical Applications in Neonatal Medicine
3rd
Edition, November, 2019
Development and Supportive Care (DSC)
Foundation for Newborn & Children (India)
B - 106, Chitranjan Park, New Delhi - 110 019, India
Email: amit19762000@yahoo.com, dscnicupeds@gmail.com
Chief Scientific Editor
Dr Amitava Sengupta
ii
iii
Contents
SECTION - 1
Chapter 1 1
Development of Fetal and Neonatal Brain
Sunil K Sinha, Shalabh Garg
Chapter 2 5
Overview of Developmentally Supportive Care (DSC) in Preemies.
Evolution of DSC Models with Core Measures & “Neuroprotection in the NICU”
Amitava Sengupta
Appendix A: Seven Neuroprotective core measures 16
Chapter 3 21
Newborn Sensory Systems and Implications in Developmentally Supportive Care
Aditya Dixit, Rakesh Tiwari
Chapter 4 27
Neuromotor Maturation and Stages of Neurobehavioral Organization of
the Preterm and High Risk Infant
Amitava Sengupta, S P Senthil Kumar
Chapter 5 31
Maturation of Sensory Systems
Amitava Sengupta
Chapter 6 35
Principles and Practices of Developmentally Supportive Care
Ms Amy Carroll
Chapter 7 46
Octopus Therapy for Preemies in NICU
Amitava Sengupta
Appendix B: Quick Tips for all NICU Caregivers 50
Appendix C: Implementing Potentially Better Practices (PBPs)
to support the neurodevelopment of infants in the NICU
53
Chapter 8 54
Therapeutic Positioning in the NICU
Amitava Sengupta
Chapter 9 60
Feeding in High- Risk Infants and Neurodevelopmental Assessment of Feeding Abilities
Amitava Sengupta
Chapter 10 64
Management of Pain in Neonates
Vikram Datta
Chapter 11 71
Use of Oral Sucrose or Dextrose in the NICU for Pain Relief Measures in Neonates
Sanjay Wazir, Gopal Agrawal
Chapter 12 78
Family Centred Care for Sick Neonates: An innovation to improve quality of care and survival beyond
newborn period
Arti Maria, Rashmi Wadhwa
iv
Chapter 13 86
Kangaroo Mother Care and Developmentally Supportive Care
Suman Rao PN, Prashantha YN
Chapter 14 91
Environmental Considerations for Reduction of Stress & Energy Conservation
Amitava Sengupta
Chapter 15 96
Cycled lighting in the NICU
Ajay Lal, Amitava Sengupta
Chapter 16 101
Therapeutic Massage in Premature Infants
Ms Hima J. B.
Chapter 17 113
Follow Up and Measuring the Perinatal Outcomes of the High Risk NICU Graduate
Win Tin
Chapter 18 120
Designing A DSC Friendly NICU
Kedar Sawleshwarkar
Chapter 19 126
Soar Analysis
Rakesh Tiwari
Chapter 20 127
My Experiences in Developmentally Supportive Care (DSC) in an Indian NICU Setting
Amy Carroll
Chapter 21 130
Harnessing Knowledge Translation and Implementation Science for Program Success: Moving
Developmentally Supportive Care into everyday practice:
Amy Carroll, Catherine Piersol
SECTION - 2
Chapter 22 138
Temperature and Humidity Control in NICU
Satish Ghanta, Anil Gupta
Chapter 23 147
Nutrition in Pre-term Infants Impact on Neurodevelopmental and Cognitive outcome
Jay Kishore
Chapter 24 154
Use of Human-Based Human Milk Fortifier in Very Low Birth Weight Infants manifesting with Intolerance
to Bovine-Based Human Milk Fortifier
Amitava Sengupta
Chapter 25 157
Natal & Neonatal Teeth
Arnab Sengupta
Chapter 26 162
Immunization of the Preterm Infant
Ashok Kumar
v
Chapter 27 172
Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy (HIE)
B. Vishnu Bhat, T.Vasanthan
Chapter 28 178
Patent Ductus Arteriosus and Haemodynamics in Newborn
Samir Gupta
Chapter 29 193
Nasal Intermittent Positive Pressure Ventilation (NIPPV) in the Newborn
Amitava Sengupta
Chapter 30 200
Less Invasive Surfactant Administration (LISA) / Minimal Invasive Surfactant Therapy (MIST) in Preterm
Neonates
Sanjay Wazir, Piyush Shah
Chapter 31 207
Lung Protective Strategies in Newborns
Vladimiras Chijenas
Chapter 32 218
BPD Beyond Neonatal Unit
Satish Ghanta
Appendix 229
vi
What began as an opportunity for an NICU posting for Amy Carroll in the year 2013, led
to an extraordinary interdisciplinary collaboration with the Paras Hospital NICU team.
The Neonatal group at Paras Hospitals, Gurgaon (NCR), India, delivers state of art and
quality care to Preterm, Fragile and/or critically ill infants in their NICU.
There was consideration of the developmental needs of the preterm /fragile or critically
ill infants and eventually, an extended role for Amy Carroll as a facilitator of an inter-
professional Developmentally Supportive Care (DSC) team evolved. The team embarked
on a DSC knowledge translation journey which initially included review of volumes of
current DSC literature and related evidence based best practices in the NICUs across
the globe. The effort was supported academically by the Occupational Therapy Doctoral
Program at Thomas Jefferson University, Philadelphia, USA, as Amy Carroll was completing
her Doctorate in the same program.
Two years of dedicated research and clinical work by the DSC team of DSC Foundation
(India) and Paras hospitals culminated in the creation of a 5 week program for the nursing
staff through knowledge translation methods.
The knowledge translation consisted of: weekly training sessions, integrated practice of
techniques, and strength-based strategic planning sessions tailored to the Paras Hospital
setting. Our vision was, and still is, to create a “Culture of Developmentally Supportive
Care” that is relevant and useful for all families and NICUs across the NCR and India.
We are ever closer to realizing that vision due to the amazing efforts of all NICU staff
including the Consultants, Resident Specialists, the NICU Nursing Staff and the DSC team.
We hope that this information will be a useful catalyst for DSC in other NICUs across our
country and abroad!
We would like to thank the Secretary NNF India (2013-14), Dr Vikram Datta for his intense
and unconditional support and encouragement, which helped us launch this programme
and made our endeavor possible.
Dr Amitava Sengupta, Fellowship Neonatology (Neth), FNNF
Director, Mother & Child Unit, Neonatology & Pediatrics
Paras Hospitals, Gurgaon (NCR), India
Chairperson & Executive Director
Development and Supportive Care (DSC) Foundation for Newborn & Children (India)
Chairperson Workshops: 37th
Annual Convention of National Neonatology Forum (NEOCON 2017)
An Initiative
vii
Contributors List
Aditya Dixit, MD
Visiting Consultant, Neonatology & Pediatrics
DSC Team, Mother & Child Unit
Paras Hospitals, Gurgaon (NCR), India
Ajay Lal, Fellowship Neonatology (NNF- India)
Consultant, Division of Neonatology, Mother & Child Unit, Paras
Hospitals, Gurgaon (NCR), India
Amitava Sengupta, Fellowship Neonatology (Neth), FNNF
Director, Mother & Child Unit, Neonatology & Pediatrics
Paras Hospitals, Gurgaon (NCR), India
Chairperson & Executive Director
Development and Supportive Care (DSC) Foundation
for Newborn & Children (India)
Amy Carroll, OTD, OTR/L
Assistant Professor, Post-professional Doctoral
Program in Occupational Therapy
Jefferson College of Health Professions
Thomas Jefferson University
Philadelphia, USA
Anil Gupta, MD, Fellowship Neonatology
Consultant, Neonatology, Little Stars Children’s Hospital, Hyderabad, India
Arnab Sengupta, BDS, MDS(Pedodontics)
Director, Kidz Dental Centre
Gurgaon (NCR), India
Arti Maria, MD, DM (Neonatology)
Professor & Head Department of Neonatology, PGIMER& Dr RML Hospital
New Delhi, India
Ashok Kumar, MD, FIAP, FNNF, FAMS
Commonwealth Fellow (Neonatology)
Professor, Neonatology Unit, Department of Pediatrics
Institute of Medical Sciences, Banaras Hindu University
Varanasi, India
B Vishnu Bhat, MD, DHA, DDE
Director and Dean (Research)
Senior Professor and HOD, Department of Neonatology,
JIPMER, Pondicherry, India
Dr Catherine Piersol, PhD, OTR/L, FAOTA
Professor & Chair, Department of Occupational Therapy
Program Director, Post-professional Doctoral Program in Occupational
TherapyJefferson College of Rehabilitation Sciences
Jefferson (Philadelphia University and Thomas Jefferson University),
Philadelphia, USA
Gopal Agrawal, MD, DM (Neonatology)
Consultant, Neonatology, Cloudnine Hospitals
Gurgaon (NCR), India
Hima B. John, Bachelor, (OT), MSc (Psychology)
Faculty, Occupational Therapy,
Christian Medical College, Vellore, India
I V Boronina, MD
Voronezh State Medical University
named after N N Burdenko, Russia
Jay Kishore, MD, DNB (Neonatology)
NICU In-charge
Senior Consultant Neonatology & Pediatrics
Max Super Specialty Hospital, Patparganj, New Delhi, India
Kedar Sawleshwarkar, MD
Fellowship Neonatology
Director, Deogiri Children’s Hospital, Aurangabad, India
Naveen Gupta, MD, DNB Neonatology
Fellowship from BC Children Hospital, Vancouver, Canada
Neonatologist and NICU Incharge, Senior Consultant - Neonatology
Rainbow Children’s Hospital, New Delhi, India
Piyush Shah, MD, Fellowship Neonatology (Australia)
Consultant Neonatology, Cloudnine Hospitals, Mumbai, India
Prakash Loganathan, MD
Consultant, University Hospital North tees Stockton, UK
Prashantha YN
Department of Neonatology St John’s Medical College Hospital,
Bangalore, India
Rakesh Tiwari, MD, MBA (HCA)
Consultant, Department of Neonatology & Pediatrics
DSC Team, Moth er & Child Unit
Paras Hospitals, Gurgaon (NCR), India
Rashmi Wadhwa
Project Coordinator, Family Centred Care, Department of Neonatology,
PGIMER& Dr RML Hospital New Delhi, India
Samir Gupta, DM MD FRCPCH FRCPI
Professor of Neonatology, Durham University,
Clinical Director, Research & Development
University Hospital of North Tees,
Stockton, UK
Sanjay Wazir, MD, DM (Neonatology)
Director: Neonatology, Cloudnine Hospitals, Gurgaon (NCR), India
President: IAP Neonatology Chapter 2017
National Faculty: NNF-IAP Advanced NRP 2010
Satish Ghanta, MD
Neonatal Fellowship (Sydney, Aus)
Bayley Scales Accredited Developmental Pediatrics (Sydney, Aus)
Pediatric & Cardiac Intensive Care Fellowship (Sydney, Aus)
Director – Neonatal & Pediatric Intensive Care Services
Little Stars Children’s Hospital, Hyderabad, India
Shalabh Garg, MD FRCPCH PGClR
Consultant Neonatologist
James Cook University Hospital
Middlesbrough, UK
S P Senthil Kumar, M.D, Fellowship Pediatric Critical Care
Consultant Pediatric Intensivist,
Department of Neonatology & Pediatrics
Columbia Asia Hospital, Bangalore, India
National Faculty: NNF-IAP Advanced NRP 2010
Sriparna Basu, MD, FRCPCH, FRCPI
Professor, Neonatology Unit, Department of Pediatrics, Institute of
Medical Sciences, Banaras Hindu University, Varanasi, India
Suman Rao, MD, DM (Neonatology)
Professor & Head, Department of Neonatology
St. John’s Medical College & Hospital
Bangalore, India
Sunil Sinha, MD PhD FRCP FRCPCH
Professor of Paediatrics, University of Durham
Consultant Neonatologist,
James Cook University Hospital, Middlesbrough, UK
Vikram Datta, MD, DNB, FNNF
WHO Fellow in Epidemiology, PSU, Thailand
Director Professor, Department of Neonatology,
Lady Hardinge Medical College, New Delhi, India
Vladimiras Chijenas, MD
Consultant Neonatologist,
Neonatal Division, Vilnius Maternity Hospital
Vilnius, Lithuania
UNICEF Consultant Team Leader 2014-15
Win Tin, FRCPCH and Neonatal Fellow
Professor of Paediatrics, University of Durham
& Senior Consultant Paediatrician.
The James Cooke University Hospital
Middlesbrough, UK
YU S Aleksandrovich, MD
St. Petersburg State Pediatric Medical University,
St. Petersburg, Russia
viii
Preface
It is with great deal of modesty as well as satisfaction, that we present the 3rd
edition of the Textbook on “Principles and
Practices of Developmentally Supportive Care (DSC) in the NICU & Clinical Applications in Neonatal Medicine”.
The field of Neonatology has experienced some remarkable progress over the last four decades in care of the
newborn. This has reflected with dramatic reductions in both neonatal and infant mortality and has enabled the
neonatal team to save more babies of lower gestational age and extremely low birth weight (ELBW). In the present
times, the incidence of prematurity is high in both western and eastern worlds. However, morbidity rate of
neurodevelopmental impairment has not decreased for this population.
The preterm infant experiences a hostile environment in the intensive care (NICU) setting as compared to the womb.
The in-utero environment of a developing fetus is characterized by generalized extremity flexion and containment,
limited light and noise exposure, sleep cycle preservation, and unrestricted access to mother via somatosensory,
auditory, and chemosensory pathways. This environment is favorable for positive sensory input which is crucial for
normal fetal brain development.
A newborn preterm infant is deprived of these basic developmental needs upon transition from the womb to the
environment of the newborn intensive care unit. This environment is typically characterized by painful procedures,
excessive light and noise exposure, interrupted and inadequate sleep, and separation from mother. Negative
replaces positive sensory input into the developing fetal brain which, as research shows, can permanently alter
normal brain development.
Developmentally Supportive Care (DSC) practices are evidence based interventions that promote newborn brain
and neurobehavior development. They minimize the stress of NICU environment, support autonomic stability,
normal motor, sensory neurological development and promote behavior state organization.
It requires a shift of attitudes regarding ownership of an infant’s care and the personhood of the preterm patient.
The section on “Clinical Applications in Neonatal Medicine” does not address all aspects of neonatology, but discusses
those clinical areas that are more novel and have greater relevance to preterm medicine and supportive care of the
newborn. A chapter on natal and neonatal teeth has also been included in this section as it is indeed a mystifying subject.
This book has been designed to provide an in depth knowledge of the various facets of Developmentally Supportive Care
(DSC) in section 1 and Clinical Applications relevant to care of preterm infants /sick newborns in section 2.
I have intensely enjoyed working with each of the authors who contributed to this book and reading their state –
of – the – art contributions. I hope the reader will share my appreciation for the outstanding quality of each of the
chapters. I am also very grateful to Mr Rakesh Ahuja from Process & Spot, New Delhi for designing and producing
this masterpiece book
I acknowledge with extreme gratitude each of the authors for their outstanding contribution.
As neonatal caregivers our goal should be to improve functional outcome, have positive neuro developmental
outcome and achieve the gold standard of “INTACT SURVIVAL” of the preterm, fragile and/or critically ill infants.
Finally I would like to dedicate this book to all newborns.
Dr Amitava Sengupta, Fellowship Neonatology (Neth), FNNF
Director: Mother & Child Unit, Neonatology & Pediatrics
Paras Hospitals, Gurgaon (NCR), India
Chairperson & Executive Director
Development and Supportive Care (DSC) Foundation for Newborn & Children (India)
Chairman Workshop Committee
37th
Annual Convention of National Neonatology Forum (NEOCON 2017)
National Assessor, NICU Accreditation Program (NNF-UNICEF).
National Instructor, FBNC Program (NNF-UNICEF).
National Faculty, NNF-IAP Advanced NRP.
ix
Message from President - 2019
National Neonatology Forum (INDIA)
Over time, significant advances of knowledge and technology in Perinatal Medicine and Neonatal intensive care
have led to increased survival of Extremely Low Birth Weight (ELBW) Micro preemies in tertiary level NICUs across
the world. Neonatal and infant mortality have shown great reduction in incidence and numbers.
However, in spite of the rapid advances, morbidity rate of Neurodevelopmental Impairment for this population has
not decreased and still remains an issue of` major concern in today’s scenario.
It gives me great pleasure to put on record my appreciation for the most invaluable and pivotal work being done
by Dr Amitava Sengupta and DSC Foundation Team in the field of of “Developmentally Supportive Care (DSC) of
Preemies and Neuroprotection in NICU”.
Under his able guidance and leadership this high quality program has indeed blossomed and spread to all levels of
NICUs across India and overseas by way of the 20 or more National DSC Workshops which have been conducted
across our country and an International one held at St Petersburg State Pediatric Medical University in Russia in
October 2018.
We are honored to have Dr Amitava as our Course Director and Lead Faculty for the Pre Conference National
Workshop on “DSC and Neuroprotection in NICU” at NEOCON 2019 being held in Hyderabad.
I am also very happy to release an excellent compilation of the third edition of the Textbook “Principles and
Practices of Developmentally Supportive Care in NICU and Clinical Applications in Neonatal Medicine”.
It has exceptional quality of content with high level of academics. The state – of – the – art contributions of all the
renowned authors have made this book a bank of knowledge presented in a very pleasing and lucid form.
Dr Amitava, NNF and I wish to congratulate you for your extra ordinary effort as Chief Scientific Editor in bringing
out this excellent manual which would be of utmost use to all Neonatal Caregivers in learning and practicing the
art of DSC and humane care in Newborns.
Dr V P Goswami
President - National Neonatology Forum (INDIA) - 2019
x
Message from Past President - 2018
National Neonatology Forum (INDIA)
Dear Dr. Amitava Sengupta,
It gives me immense pleasure to know that under your leadership such a high quality training programm is being
carried out on“ Developmentally Supportive Newborn Care in Neonatal Intensive Care Units “ with the help of able
faculty from all over the country and overseas.
With the initiative of Government of India ,almost each district is having 12-20 bedded or larger neonatal units,
fully equipped for Level II Newborn care with adequate space, equipment and manpower. Here small and sick
newborns are receiving standard care and are surviving. This is like a dream coming true for my age Neonatologists.
With advances and improvement in perinatal care (accompanied by “State of Art” Obstetric care), more and more
extremely preterm and ELBW babies are surviving. The quality of life in such babies is at times under question.
Preterms in NICUs are exposed to hostile and painful environment compared to the calm and protected intrauterine
environment. This definitely affects their survival and subsequent life. Developmentally supportive care for these
babies is as essential as their survival.
You have not only developed such supportive care tools for your unit, but also taken the initiative to spread this
message by organizing such workshops of immense importance in different corners of our country with the help
of International and National faculty.GOI has now also incorporated the quality and developmentally supportive
issues in their India Newborn Action Plan(INAP), launched in September 2014.
The National Neonatology Forum (India) recognizes your efforts and supports such extraordinary endeavours for
intact and quality survival of sick and healthy newborns of country. Prematurity is emerging out to be a leading
cause mortality and morbidity not only in India but the world over also. Hence these intense workshops are most
appropriate in today’s neonatal scenario.
The compilation of such an extra ordinary effort can be clearly seen in your third edition of the book “Principles
and Practices of Developmentally Supportive Care in NICU and Clinical Applications in Neonatal Medicine” edited
by you. I wish to congratulate you Dr. Amitava Sengupta.
NNF and I personally wish you all the best not only for the present workshop but for many more such workshops
in future as well for your excellent compilation.
Dr B D Bhatia, MD, DCH, FICN, FIAP, FAMS, FNNF
Past President - National Neonatology Forum (INDIA) - 2018
xi
Message from Past President
Indian Academy of Pediatrics - 2018
One of the most important career choices I made in my early days is to become an intensivist. Pediatric intensive
care was still in its infancy those days. I somehow gravitated towards this discipline and finally made it my area of
super specialization. Since then I have been a witness to the continuous development of the field, a key feature
of which has been the gradual emergence of PICU and NICU as separate entities functioning within the overall
healthcare eco-system.
The NICU, especially, calls for expertise of a far higher order and it had initially suffered from a lack of regular feeds
and updates to empower the neonatal intensivist to better deal with the unimaginable range of challenges one
could be confronted with in NICU settings. Thankfully, this lacuna is now being filled by the increasing amount of
medical literature coming out, which is focused exclusively on issues pertaining to NICU.
I see this book, Principles and Practices of Developmentally Supportive Care (DSC) in the NICU, as a valuable
addition to the repertoire of scientific material dealing with NICU. The latest and vastly expanded edition also has
the benefit of a supplementary section on Clinical Applications in Neonatal Medicine. The book is an excellent
compilation of highly relevant subjects, which are dwelled upon in a comprehensive and credible manner by
authors of repute. The presentation is well organized, neat and pleasing to the eye. I am especially impressed by
the high quality of the content which should certainly fill the NICU specialist with confidence.
I congratulate all members of the editorial team, especially the Chief Scientific Editor, Dr Amitava Sengupta on
their well directed effort to enhance the arsenal in the NICU. I also wish to place on record my appreciation for
Development and Supportive Care (DSC) Foundation for Newborn & Children (India), which has been taking the
lead in developing more resources for functioning effectively in this rarified field.
I look forward to the future editions of this book to continue on the path of excellence and help transform the NICU
into a place of strength and hope for all.
Dr Santosh T Soans
Past President, Indian Academy of Pediatrics - 2018
xii
It is increasingly clear that newborn babies respond to and are affected by the environment around them. Compared
with the womb, even the best designed modern Neonatal Intensive Care Unit (NICU) is a hostile, noisy and
dangerous environment which is challenging to the immature homeostatic mechanisms of a preterm baby. It is the
duty of all neonatal practitioners to minimize the physical and psychological disturbance to the baby during a time
of rapid neuronal migration and development and to support the whole family in adapting to their circumstances
in order to promote the best long-term outcome.
All units involved with the care of sick infants should also develop strategies to promote the attachment of
parents to their sick infants. A good parent - infant attachment has been shown to produce both short term
and long-term benefits in terms of physical and neurodevelomental outcomes. Various forms of interventions
are being implemented, on individual basis such as NIDCAP and Kangaroo care. As they involve a number of
physiological processes, we do not know which individual item of intervention is most effective and hence the need
for continuing research and development in this area.
Dr Amitava Sengupta and his team have done a fantastic job in promoting the concept and implementation of
Developmental Care in India through various seminars, workshops and books written by many eminent doctors in
India and abroad. With continuing support and encouragement, I have no doubt that Dr Sengupta and his team
will bring in something valuable which will be good for everybody: individual patients, family, society and nation.
I wish him the very best for further success in this area.
Dr Sunil Sinha, MD PhD FRCP FRCPCH
Professor of Paediatrics, University of Durham
Consultant Neonatologist, James Cook University Hospital, Middlesbrough
United Kingdom (UK)
Message from Overseas
xiii
Governing Body
Chairperson & Executive Director
Development and Supportive Care (DSC)
Foundation for Newborn and Children
Amitava Sengupta, Fellowship Neonatology (Neth), FNNF
Director: Mother & Child Unit, Neonatology & Pediatrics
Paras Hospitals, Gurgaon (NCR), India
Chairperson & Executive Director
Development and Supportive Care (DSC) Foundation for Newborn & Children (India)
Chairman Workshop Committee
37th
Annual Convention of National Neonatology Forum (NEOCON 2017)
National Assessor, NICU Accreditation Program (NNF-UNICEF).
National Instructor, FBNC Program (NNF-UNICEF).
National Faculty, NNF-IAP Advanced NRP.
Chief Advisor: 49th
Annual National Conference of IAP (Pedicon 2012).
Sunil Sinha
MD PhD FRCP FRCPCH
Professor of Paediatrics,
University of Durham
Consultant
Neonatologist,
James Cook
University Hospital,
Middlesbrough
United Kingdom (UK)
Executive Members
Vikram Datta, MD, DNB, FNNF
Director Professor, Department of Neonatology,
Lady Hardinge Medical College, New Delhi, India
Member National Editorial Board (2015-17)
Indian Journal of Pediatrics
Secretary (2013-14)
National Neonatology Forum, India
Editor in Chief (2013-14)
Journal of Neonatology, India
WHO Fellow in Epidemiology, PSU, Thailand
Sushil Srivastava, MD, MBA (HCA)
Associate Professor
Division of Neonatology, Department of Pediatrics
University College of Medical Sciences
& G.T.B. Hospital
Dilshad Garden, Delhi, India
Amy Carroll, OTD, OTR/L
Assistant Professor, Post-professional Doctoral
Program in Occupational Therapy
Jefferson College of Health Professions
Thomas Jefferson University
Philadelphia, PA 19107, USA
Ashok Kumar, MD, FIAP, FNNF, FAMS
Professor & Head, Department of Pediatrics
Institute of Medical Sciences
Banaras Hindu University (BHU), Varanasi
Commonwealth Fellow in Neonatology (UK)
ICMR International Fellowship (Norway)
Visiting Professor, Ulm University (Germany)
Governing Body Trustee
Mrs Anuradha Sengupta
Governing Body Trustee
DSC Foundation for Newborn & Children
New Delhi
Dr Catherine Piersol
PhD, OTR/L, FAOTA
Professor & Chair, Department of
Occupational Therapy
Program Director, Post-professional
Doctoral Program in Occupational
TherapyJefferson College of
Rehabilitation Sciences
Jefferson (Philadelphia University
and Thomas Jefferson University),
Philadelphia, USA
Win Tin, FRCPCH and Neonatal Fellow
Professor of Paediatrics, University of Durham
& Senior Consultant Paediatrician.
The James Cooke University Hospital
Middlesbrough, TS4 3BW
United Kingdom (UK)
Vladimiras Chijenas
MD
Consultant Neonatologist,
Neonatal Division, Vilnius
Maternity Hospital
Vilnius, Lithuania
UNICEF Consultant team
leader 2014-15
Samir Gupta, DM MRCP MD FRCPCH FRCPI
Professor of Neonatology, Durham University
Honorary Research Fellow, University of Oxford
Director, Research & Development
Consultant Neonatologist
University Hospital of North Tees
International Advisory Members
xiv
Suman Rao, MD, DM (Neonatology)
Professor & Head, Department of Neonatology
St John’s Medical College and Hospital
Bengaluru, India
Archana Bilagi, MD
Secretary, NNF - Karnataka Chapter 2014-16
Member, ROP committee, NNF Karnataka
Consultant Neonatologist
St. Philomena’s Hospital, Bengaluru, India
Satish Ghanta, MD (Paed) Manipal
Neonatal Fellowship (Sydney, Aus)
Bayley Scales Accredited Developmental Pediatrics
(Sydney, Aus)
Pediatric & Cardiac Intensive Care Fellowship
(Sydney, Aus)
Director, Neonatal & Pediatric Intensive Care Services
Little Stars Children’s Hospital, Hyderabad
Niranjan Thomas, MD, DCH, DNB
Professor & Head, Department of Neonatology
Christian Medical College (CMC)
Vellore, Tamil Nadu, India
Copyright and Photocopying
All rights reserved. No part of this publication may be reproduced, stored or transmitted in any form or by any means, electronic or mechanical,
including photocopy, recording or any information storage and retrieval system, without permission in writing from the chief scientific editor
of the book.
Disclaimer
The publisher and the chief scientific editor cannot be held responsible for errors or any consequences arising from the use of information
contained in this book, the views and opinions expressed do not necessarily reflect those of the publisher or chief scientific editor.
Kedar Sawleshwarkar, MBBS,MD
Director NICU, Deogiri Children’s Hospital, Aurangabad
Formerly Associate Professor, Govt Medical College,
Aurangabad
National Faculty NRP India
National Instructor: FBNC Program (NNF-UNICEF)
2014
President IAP Aurangabad 2015
Sudip Dutta, MD
Professor & HOD
Department of Pediatrics
Sikkim Manipal Institute of Medical Sciences
Gangtok, Sikkim, India
S P Senthil Kumar, M.D. (PAED)
Fellowship Pediatric Critical Care
Consultant Pediatric Intensivist,
Department of Neonatology & Pediatrics
Columbia Asia Hospital, Bangalore
National Faculty: NNF-IAP Advanced NRP 2010
Scientific Coordinators
Sanjay Wazir, MD, DM Neonatology
(PGI Chandigarh)
Director: Neonatology
Cloudnine Hospitals, Gurgaon (NCR), India
National Faculty: NNF-IAP Advanced NRP 2010
Rakesh Tiwari, MD, MBA (HCA)
Consultant, Department of Neonatology & Pediatrics
DSC Team, Mother & Child Unit
Paras Hospitals, Gurgaon (NCR), India
Shalabh Garg, MD FRCPCH PGClR
Consultant Neonatologist
James Cook University Hospital
Middlesbrough, UK
Ajay Lal, Fellowship Neonatology (NNF, India), DCH
Medical Director
Lal Superspeciality Hospital
“Institute of Newborn Sciences” Gurugram (NCR)
India
Dr Sandeep S Patil, MBBS, MD (Pediatrics)
DM(Neonatology), Fellow PCCM(ISCCM)
Director CARE Advanced Neonatal Center
Nanded, Maharashtra
Arnab Sengupta, BDS, MDS (Pedodontics)
BLS Certified from AHA (American Heart
Association)
Director
KIDZ Dental Centre
Gurgaon (NCR), India
Advisor, Pediatric Dental Sciences
DSC Foundation (India)

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Dsc foundation nov 2019 final

  • 1. Development and Supportive Care (DSC) Foundation for Newborn & Children (India) B - 106, Chitranjan Park, New Delhi - 110 019, India Email: amit19762000@yahoo.com, dscnicupeds@gmail.com 3rd Edition, November, 2019 Principles and Practices of Developmentally Supportive Care (DSC) in the NICU & Clinical Applications in Neonatal Medicine Chief Scientific Editor Dr Amitava Sengupta
  • 2.
  • 3. i Principles and Practices of Developmentally Supportive Care (DSC) in the NICU & Clinical Applications in Neonatal Medicine 3rd Edition, November, 2019 Development and Supportive Care (DSC) Foundation for Newborn & Children (India) B - 106, Chitranjan Park, New Delhi - 110 019, India Email: amit19762000@yahoo.com, dscnicupeds@gmail.com Chief Scientific Editor Dr Amitava Sengupta
  • 4. ii
  • 5. iii Contents SECTION - 1 Chapter 1 1 Development of Fetal and Neonatal Brain Sunil K Sinha, Shalabh Garg Chapter 2 5 Overview of Developmentally Supportive Care (DSC) in Preemies. Evolution of DSC Models with Core Measures & “Neuroprotection in the NICU” Amitava Sengupta Appendix A: Seven Neuroprotective core measures 16 Chapter 3 21 Newborn Sensory Systems and Implications in Developmentally Supportive Care Aditya Dixit, Rakesh Tiwari Chapter 4 27 Neuromotor Maturation and Stages of Neurobehavioral Organization of the Preterm and High Risk Infant Amitava Sengupta, S P Senthil Kumar Chapter 5 31 Maturation of Sensory Systems Amitava Sengupta Chapter 6 35 Principles and Practices of Developmentally Supportive Care Ms Amy Carroll Chapter 7 46 Octopus Therapy for Preemies in NICU Amitava Sengupta Appendix B: Quick Tips for all NICU Caregivers 50 Appendix C: Implementing Potentially Better Practices (PBPs) to support the neurodevelopment of infants in the NICU 53 Chapter 8 54 Therapeutic Positioning in the NICU Amitava Sengupta Chapter 9 60 Feeding in High- Risk Infants and Neurodevelopmental Assessment of Feeding Abilities Amitava Sengupta Chapter 10 64 Management of Pain in Neonates Vikram Datta Chapter 11 71 Use of Oral Sucrose or Dextrose in the NICU for Pain Relief Measures in Neonates Sanjay Wazir, Gopal Agrawal Chapter 12 78 Family Centred Care for Sick Neonates: An innovation to improve quality of care and survival beyond newborn period Arti Maria, Rashmi Wadhwa
  • 6. iv Chapter 13 86 Kangaroo Mother Care and Developmentally Supportive Care Suman Rao PN, Prashantha YN Chapter 14 91 Environmental Considerations for Reduction of Stress & Energy Conservation Amitava Sengupta Chapter 15 96 Cycled lighting in the NICU Ajay Lal, Amitava Sengupta Chapter 16 101 Therapeutic Massage in Premature Infants Ms Hima J. B. Chapter 17 113 Follow Up and Measuring the Perinatal Outcomes of the High Risk NICU Graduate Win Tin Chapter 18 120 Designing A DSC Friendly NICU Kedar Sawleshwarkar Chapter 19 126 Soar Analysis Rakesh Tiwari Chapter 20 127 My Experiences in Developmentally Supportive Care (DSC) in an Indian NICU Setting Amy Carroll Chapter 21 130 Harnessing Knowledge Translation and Implementation Science for Program Success: Moving Developmentally Supportive Care into everyday practice: Amy Carroll, Catherine Piersol SECTION - 2 Chapter 22 138 Temperature and Humidity Control in NICU Satish Ghanta, Anil Gupta Chapter 23 147 Nutrition in Pre-term Infants Impact on Neurodevelopmental and Cognitive outcome Jay Kishore Chapter 24 154 Use of Human-Based Human Milk Fortifier in Very Low Birth Weight Infants manifesting with Intolerance to Bovine-Based Human Milk Fortifier Amitava Sengupta Chapter 25 157 Natal & Neonatal Teeth Arnab Sengupta Chapter 26 162 Immunization of the Preterm Infant Ashok Kumar
  • 7. v Chapter 27 172 Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy (HIE) B. Vishnu Bhat, T.Vasanthan Chapter 28 178 Patent Ductus Arteriosus and Haemodynamics in Newborn Samir Gupta Chapter 29 193 Nasal Intermittent Positive Pressure Ventilation (NIPPV) in the Newborn Amitava Sengupta Chapter 30 200 Less Invasive Surfactant Administration (LISA) / Minimal Invasive Surfactant Therapy (MIST) in Preterm Neonates Sanjay Wazir, Piyush Shah Chapter 31 207 Lung Protective Strategies in Newborns Vladimiras Chijenas Chapter 32 218 BPD Beyond Neonatal Unit Satish Ghanta Appendix 229
  • 8. vi What began as an opportunity for an NICU posting for Amy Carroll in the year 2013, led to an extraordinary interdisciplinary collaboration with the Paras Hospital NICU team. The Neonatal group at Paras Hospitals, Gurgaon (NCR), India, delivers state of art and quality care to Preterm, Fragile and/or critically ill infants in their NICU. There was consideration of the developmental needs of the preterm /fragile or critically ill infants and eventually, an extended role for Amy Carroll as a facilitator of an inter- professional Developmentally Supportive Care (DSC) team evolved. The team embarked on a DSC knowledge translation journey which initially included review of volumes of current DSC literature and related evidence based best practices in the NICUs across the globe. The effort was supported academically by the Occupational Therapy Doctoral Program at Thomas Jefferson University, Philadelphia, USA, as Amy Carroll was completing her Doctorate in the same program. Two years of dedicated research and clinical work by the DSC team of DSC Foundation (India) and Paras hospitals culminated in the creation of a 5 week program for the nursing staff through knowledge translation methods. The knowledge translation consisted of: weekly training sessions, integrated practice of techniques, and strength-based strategic planning sessions tailored to the Paras Hospital setting. Our vision was, and still is, to create a “Culture of Developmentally Supportive Care” that is relevant and useful for all families and NICUs across the NCR and India. We are ever closer to realizing that vision due to the amazing efforts of all NICU staff including the Consultants, Resident Specialists, the NICU Nursing Staff and the DSC team. We hope that this information will be a useful catalyst for DSC in other NICUs across our country and abroad! We would like to thank the Secretary NNF India (2013-14), Dr Vikram Datta for his intense and unconditional support and encouragement, which helped us launch this programme and made our endeavor possible. Dr Amitava Sengupta, Fellowship Neonatology (Neth), FNNF Director, Mother & Child Unit, Neonatology & Pediatrics Paras Hospitals, Gurgaon (NCR), India Chairperson & Executive Director Development and Supportive Care (DSC) Foundation for Newborn & Children (India) Chairperson Workshops: 37th Annual Convention of National Neonatology Forum (NEOCON 2017) An Initiative
  • 9. vii Contributors List Aditya Dixit, MD Visiting Consultant, Neonatology & Pediatrics DSC Team, Mother & Child Unit Paras Hospitals, Gurgaon (NCR), India Ajay Lal, Fellowship Neonatology (NNF- India) Consultant, Division of Neonatology, Mother & Child Unit, Paras Hospitals, Gurgaon (NCR), India Amitava Sengupta, Fellowship Neonatology (Neth), FNNF Director, Mother & Child Unit, Neonatology & Pediatrics Paras Hospitals, Gurgaon (NCR), India Chairperson & Executive Director Development and Supportive Care (DSC) Foundation for Newborn & Children (India) Amy Carroll, OTD, OTR/L Assistant Professor, Post-professional Doctoral Program in Occupational Therapy Jefferson College of Health Professions Thomas Jefferson University Philadelphia, USA Anil Gupta, MD, Fellowship Neonatology Consultant, Neonatology, Little Stars Children’s Hospital, Hyderabad, India Arnab Sengupta, BDS, MDS(Pedodontics) Director, Kidz Dental Centre Gurgaon (NCR), India Arti Maria, MD, DM (Neonatology) Professor & Head Department of Neonatology, PGIMER& Dr RML Hospital New Delhi, India Ashok Kumar, MD, FIAP, FNNF, FAMS Commonwealth Fellow (Neonatology) Professor, Neonatology Unit, Department of Pediatrics Institute of Medical Sciences, Banaras Hindu University Varanasi, India B Vishnu Bhat, MD, DHA, DDE Director and Dean (Research) Senior Professor and HOD, Department of Neonatology, JIPMER, Pondicherry, India Dr Catherine Piersol, PhD, OTR/L, FAOTA Professor & Chair, Department of Occupational Therapy Program Director, Post-professional Doctoral Program in Occupational TherapyJefferson College of Rehabilitation Sciences Jefferson (Philadelphia University and Thomas Jefferson University), Philadelphia, USA Gopal Agrawal, MD, DM (Neonatology) Consultant, Neonatology, Cloudnine Hospitals Gurgaon (NCR), India Hima B. John, Bachelor, (OT), MSc (Psychology) Faculty, Occupational Therapy, Christian Medical College, Vellore, India I V Boronina, MD Voronezh State Medical University named after N N Burdenko, Russia Jay Kishore, MD, DNB (Neonatology) NICU In-charge Senior Consultant Neonatology & Pediatrics Max Super Specialty Hospital, Patparganj, New Delhi, India Kedar Sawleshwarkar, MD Fellowship Neonatology Director, Deogiri Children’s Hospital, Aurangabad, India Naveen Gupta, MD, DNB Neonatology Fellowship from BC Children Hospital, Vancouver, Canada Neonatologist and NICU Incharge, Senior Consultant - Neonatology Rainbow Children’s Hospital, New Delhi, India Piyush Shah, MD, Fellowship Neonatology (Australia) Consultant Neonatology, Cloudnine Hospitals, Mumbai, India Prakash Loganathan, MD Consultant, University Hospital North tees Stockton, UK Prashantha YN Department of Neonatology St John’s Medical College Hospital, Bangalore, India Rakesh Tiwari, MD, MBA (HCA) Consultant, Department of Neonatology & Pediatrics DSC Team, Moth er & Child Unit Paras Hospitals, Gurgaon (NCR), India Rashmi Wadhwa Project Coordinator, Family Centred Care, Department of Neonatology, PGIMER& Dr RML Hospital New Delhi, India Samir Gupta, DM MD FRCPCH FRCPI Professor of Neonatology, Durham University, Clinical Director, Research & Development University Hospital of North Tees, Stockton, UK Sanjay Wazir, MD, DM (Neonatology) Director: Neonatology, Cloudnine Hospitals, Gurgaon (NCR), India President: IAP Neonatology Chapter 2017 National Faculty: NNF-IAP Advanced NRP 2010 Satish Ghanta, MD Neonatal Fellowship (Sydney, Aus) Bayley Scales Accredited Developmental Pediatrics (Sydney, Aus) Pediatric & Cardiac Intensive Care Fellowship (Sydney, Aus) Director – Neonatal & Pediatric Intensive Care Services Little Stars Children’s Hospital, Hyderabad, India Shalabh Garg, MD FRCPCH PGClR Consultant Neonatologist James Cook University Hospital Middlesbrough, UK S P Senthil Kumar, M.D, Fellowship Pediatric Critical Care Consultant Pediatric Intensivist, Department of Neonatology & Pediatrics Columbia Asia Hospital, Bangalore, India National Faculty: NNF-IAP Advanced NRP 2010 Sriparna Basu, MD, FRCPCH, FRCPI Professor, Neonatology Unit, Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India Suman Rao, MD, DM (Neonatology) Professor & Head, Department of Neonatology St. John’s Medical College & Hospital Bangalore, India Sunil Sinha, MD PhD FRCP FRCPCH Professor of Paediatrics, University of Durham Consultant Neonatologist, James Cook University Hospital, Middlesbrough, UK Vikram Datta, MD, DNB, FNNF WHO Fellow in Epidemiology, PSU, Thailand Director Professor, Department of Neonatology, Lady Hardinge Medical College, New Delhi, India Vladimiras Chijenas, MD Consultant Neonatologist, Neonatal Division, Vilnius Maternity Hospital Vilnius, Lithuania UNICEF Consultant Team Leader 2014-15 Win Tin, FRCPCH and Neonatal Fellow Professor of Paediatrics, University of Durham & Senior Consultant Paediatrician. The James Cooke University Hospital Middlesbrough, UK YU S Aleksandrovich, MD St. Petersburg State Pediatric Medical University, St. Petersburg, Russia
  • 10. viii Preface It is with great deal of modesty as well as satisfaction, that we present the 3rd edition of the Textbook on “Principles and Practices of Developmentally Supportive Care (DSC) in the NICU & Clinical Applications in Neonatal Medicine”. The field of Neonatology has experienced some remarkable progress over the last four decades in care of the newborn. This has reflected with dramatic reductions in both neonatal and infant mortality and has enabled the neonatal team to save more babies of lower gestational age and extremely low birth weight (ELBW). In the present times, the incidence of prematurity is high in both western and eastern worlds. However, morbidity rate of neurodevelopmental impairment has not decreased for this population. The preterm infant experiences a hostile environment in the intensive care (NICU) setting as compared to the womb. The in-utero environment of a developing fetus is characterized by generalized extremity flexion and containment, limited light and noise exposure, sleep cycle preservation, and unrestricted access to mother via somatosensory, auditory, and chemosensory pathways. This environment is favorable for positive sensory input which is crucial for normal fetal brain development. A newborn preterm infant is deprived of these basic developmental needs upon transition from the womb to the environment of the newborn intensive care unit. This environment is typically characterized by painful procedures, excessive light and noise exposure, interrupted and inadequate sleep, and separation from mother. Negative replaces positive sensory input into the developing fetal brain which, as research shows, can permanently alter normal brain development. Developmentally Supportive Care (DSC) practices are evidence based interventions that promote newborn brain and neurobehavior development. They minimize the stress of NICU environment, support autonomic stability, normal motor, sensory neurological development and promote behavior state organization. It requires a shift of attitudes regarding ownership of an infant’s care and the personhood of the preterm patient. The section on “Clinical Applications in Neonatal Medicine” does not address all aspects of neonatology, but discusses those clinical areas that are more novel and have greater relevance to preterm medicine and supportive care of the newborn. A chapter on natal and neonatal teeth has also been included in this section as it is indeed a mystifying subject. This book has been designed to provide an in depth knowledge of the various facets of Developmentally Supportive Care (DSC) in section 1 and Clinical Applications relevant to care of preterm infants /sick newborns in section 2. I have intensely enjoyed working with each of the authors who contributed to this book and reading their state – of – the – art contributions. I hope the reader will share my appreciation for the outstanding quality of each of the chapters. I am also very grateful to Mr Rakesh Ahuja from Process & Spot, New Delhi for designing and producing this masterpiece book I acknowledge with extreme gratitude each of the authors for their outstanding contribution. As neonatal caregivers our goal should be to improve functional outcome, have positive neuro developmental outcome and achieve the gold standard of “INTACT SURVIVAL” of the preterm, fragile and/or critically ill infants. Finally I would like to dedicate this book to all newborns. Dr Amitava Sengupta, Fellowship Neonatology (Neth), FNNF Director: Mother & Child Unit, Neonatology & Pediatrics Paras Hospitals, Gurgaon (NCR), India Chairperson & Executive Director Development and Supportive Care (DSC) Foundation for Newborn & Children (India) Chairman Workshop Committee 37th Annual Convention of National Neonatology Forum (NEOCON 2017) National Assessor, NICU Accreditation Program (NNF-UNICEF). National Instructor, FBNC Program (NNF-UNICEF). National Faculty, NNF-IAP Advanced NRP.
  • 11. ix Message from President - 2019 National Neonatology Forum (INDIA) Over time, significant advances of knowledge and technology in Perinatal Medicine and Neonatal intensive care have led to increased survival of Extremely Low Birth Weight (ELBW) Micro preemies in tertiary level NICUs across the world. Neonatal and infant mortality have shown great reduction in incidence and numbers. However, in spite of the rapid advances, morbidity rate of Neurodevelopmental Impairment for this population has not decreased and still remains an issue of` major concern in today’s scenario. It gives me great pleasure to put on record my appreciation for the most invaluable and pivotal work being done by Dr Amitava Sengupta and DSC Foundation Team in the field of of “Developmentally Supportive Care (DSC) of Preemies and Neuroprotection in NICU”. Under his able guidance and leadership this high quality program has indeed blossomed and spread to all levels of NICUs across India and overseas by way of the 20 or more National DSC Workshops which have been conducted across our country and an International one held at St Petersburg State Pediatric Medical University in Russia in October 2018. We are honored to have Dr Amitava as our Course Director and Lead Faculty for the Pre Conference National Workshop on “DSC and Neuroprotection in NICU” at NEOCON 2019 being held in Hyderabad. I am also very happy to release an excellent compilation of the third edition of the Textbook “Principles and Practices of Developmentally Supportive Care in NICU and Clinical Applications in Neonatal Medicine”. It has exceptional quality of content with high level of academics. The state – of – the – art contributions of all the renowned authors have made this book a bank of knowledge presented in a very pleasing and lucid form. Dr Amitava, NNF and I wish to congratulate you for your extra ordinary effort as Chief Scientific Editor in bringing out this excellent manual which would be of utmost use to all Neonatal Caregivers in learning and practicing the art of DSC and humane care in Newborns. Dr V P Goswami President - National Neonatology Forum (INDIA) - 2019
  • 12. x Message from Past President - 2018 National Neonatology Forum (INDIA) Dear Dr. Amitava Sengupta, It gives me immense pleasure to know that under your leadership such a high quality training programm is being carried out on“ Developmentally Supportive Newborn Care in Neonatal Intensive Care Units “ with the help of able faculty from all over the country and overseas. With the initiative of Government of India ,almost each district is having 12-20 bedded or larger neonatal units, fully equipped for Level II Newborn care with adequate space, equipment and manpower. Here small and sick newborns are receiving standard care and are surviving. This is like a dream coming true for my age Neonatologists. With advances and improvement in perinatal care (accompanied by “State of Art” Obstetric care), more and more extremely preterm and ELBW babies are surviving. The quality of life in such babies is at times under question. Preterms in NICUs are exposed to hostile and painful environment compared to the calm and protected intrauterine environment. This definitely affects their survival and subsequent life. Developmentally supportive care for these babies is as essential as their survival. You have not only developed such supportive care tools for your unit, but also taken the initiative to spread this message by organizing such workshops of immense importance in different corners of our country with the help of International and National faculty.GOI has now also incorporated the quality and developmentally supportive issues in their India Newborn Action Plan(INAP), launched in September 2014. The National Neonatology Forum (India) recognizes your efforts and supports such extraordinary endeavours for intact and quality survival of sick and healthy newborns of country. Prematurity is emerging out to be a leading cause mortality and morbidity not only in India but the world over also. Hence these intense workshops are most appropriate in today’s neonatal scenario. The compilation of such an extra ordinary effort can be clearly seen in your third edition of the book “Principles and Practices of Developmentally Supportive Care in NICU and Clinical Applications in Neonatal Medicine” edited by you. I wish to congratulate you Dr. Amitava Sengupta. NNF and I personally wish you all the best not only for the present workshop but for many more such workshops in future as well for your excellent compilation. Dr B D Bhatia, MD, DCH, FICN, FIAP, FAMS, FNNF Past President - National Neonatology Forum (INDIA) - 2018
  • 13. xi Message from Past President Indian Academy of Pediatrics - 2018 One of the most important career choices I made in my early days is to become an intensivist. Pediatric intensive care was still in its infancy those days. I somehow gravitated towards this discipline and finally made it my area of super specialization. Since then I have been a witness to the continuous development of the field, a key feature of which has been the gradual emergence of PICU and NICU as separate entities functioning within the overall healthcare eco-system. The NICU, especially, calls for expertise of a far higher order and it had initially suffered from a lack of regular feeds and updates to empower the neonatal intensivist to better deal with the unimaginable range of challenges one could be confronted with in NICU settings. Thankfully, this lacuna is now being filled by the increasing amount of medical literature coming out, which is focused exclusively on issues pertaining to NICU. I see this book, Principles and Practices of Developmentally Supportive Care (DSC) in the NICU, as a valuable addition to the repertoire of scientific material dealing with NICU. The latest and vastly expanded edition also has the benefit of a supplementary section on Clinical Applications in Neonatal Medicine. The book is an excellent compilation of highly relevant subjects, which are dwelled upon in a comprehensive and credible manner by authors of repute. The presentation is well organized, neat and pleasing to the eye. I am especially impressed by the high quality of the content which should certainly fill the NICU specialist with confidence. I congratulate all members of the editorial team, especially the Chief Scientific Editor, Dr Amitava Sengupta on their well directed effort to enhance the arsenal in the NICU. I also wish to place on record my appreciation for Development and Supportive Care (DSC) Foundation for Newborn & Children (India), which has been taking the lead in developing more resources for functioning effectively in this rarified field. I look forward to the future editions of this book to continue on the path of excellence and help transform the NICU into a place of strength and hope for all. Dr Santosh T Soans Past President, Indian Academy of Pediatrics - 2018
  • 14. xii It is increasingly clear that newborn babies respond to and are affected by the environment around them. Compared with the womb, even the best designed modern Neonatal Intensive Care Unit (NICU) is a hostile, noisy and dangerous environment which is challenging to the immature homeostatic mechanisms of a preterm baby. It is the duty of all neonatal practitioners to minimize the physical and psychological disturbance to the baby during a time of rapid neuronal migration and development and to support the whole family in adapting to their circumstances in order to promote the best long-term outcome. All units involved with the care of sick infants should also develop strategies to promote the attachment of parents to their sick infants. A good parent - infant attachment has been shown to produce both short term and long-term benefits in terms of physical and neurodevelomental outcomes. Various forms of interventions are being implemented, on individual basis such as NIDCAP and Kangaroo care. As they involve a number of physiological processes, we do not know which individual item of intervention is most effective and hence the need for continuing research and development in this area. Dr Amitava Sengupta and his team have done a fantastic job in promoting the concept and implementation of Developmental Care in India through various seminars, workshops and books written by many eminent doctors in India and abroad. With continuing support and encouragement, I have no doubt that Dr Sengupta and his team will bring in something valuable which will be good for everybody: individual patients, family, society and nation. I wish him the very best for further success in this area. Dr Sunil Sinha, MD PhD FRCP FRCPCH Professor of Paediatrics, University of Durham Consultant Neonatologist, James Cook University Hospital, Middlesbrough United Kingdom (UK) Message from Overseas
  • 15. xiii Governing Body Chairperson & Executive Director Development and Supportive Care (DSC) Foundation for Newborn and Children Amitava Sengupta, Fellowship Neonatology (Neth), FNNF Director: Mother & Child Unit, Neonatology & Pediatrics Paras Hospitals, Gurgaon (NCR), India Chairperson & Executive Director Development and Supportive Care (DSC) Foundation for Newborn & Children (India) Chairman Workshop Committee 37th Annual Convention of National Neonatology Forum (NEOCON 2017) National Assessor, NICU Accreditation Program (NNF-UNICEF). National Instructor, FBNC Program (NNF-UNICEF). National Faculty, NNF-IAP Advanced NRP. Chief Advisor: 49th Annual National Conference of IAP (Pedicon 2012). Sunil Sinha MD PhD FRCP FRCPCH Professor of Paediatrics, University of Durham Consultant Neonatologist, James Cook University Hospital, Middlesbrough United Kingdom (UK) Executive Members Vikram Datta, MD, DNB, FNNF Director Professor, Department of Neonatology, Lady Hardinge Medical College, New Delhi, India Member National Editorial Board (2015-17) Indian Journal of Pediatrics Secretary (2013-14) National Neonatology Forum, India Editor in Chief (2013-14) Journal of Neonatology, India WHO Fellow in Epidemiology, PSU, Thailand Sushil Srivastava, MD, MBA (HCA) Associate Professor Division of Neonatology, Department of Pediatrics University College of Medical Sciences & G.T.B. Hospital Dilshad Garden, Delhi, India Amy Carroll, OTD, OTR/L Assistant Professor, Post-professional Doctoral Program in Occupational Therapy Jefferson College of Health Professions Thomas Jefferson University Philadelphia, PA 19107, USA Ashok Kumar, MD, FIAP, FNNF, FAMS Professor & Head, Department of Pediatrics Institute of Medical Sciences Banaras Hindu University (BHU), Varanasi Commonwealth Fellow in Neonatology (UK) ICMR International Fellowship (Norway) Visiting Professor, Ulm University (Germany) Governing Body Trustee Mrs Anuradha Sengupta Governing Body Trustee DSC Foundation for Newborn & Children New Delhi Dr Catherine Piersol PhD, OTR/L, FAOTA Professor & Chair, Department of Occupational Therapy Program Director, Post-professional Doctoral Program in Occupational TherapyJefferson College of Rehabilitation Sciences Jefferson (Philadelphia University and Thomas Jefferson University), Philadelphia, USA Win Tin, FRCPCH and Neonatal Fellow Professor of Paediatrics, University of Durham & Senior Consultant Paediatrician. The James Cooke University Hospital Middlesbrough, TS4 3BW United Kingdom (UK) Vladimiras Chijenas MD Consultant Neonatologist, Neonatal Division, Vilnius Maternity Hospital Vilnius, Lithuania UNICEF Consultant team leader 2014-15 Samir Gupta, DM MRCP MD FRCPCH FRCPI Professor of Neonatology, Durham University Honorary Research Fellow, University of Oxford Director, Research & Development Consultant Neonatologist University Hospital of North Tees International Advisory Members
  • 16. xiv Suman Rao, MD, DM (Neonatology) Professor & Head, Department of Neonatology St John’s Medical College and Hospital Bengaluru, India Archana Bilagi, MD Secretary, NNF - Karnataka Chapter 2014-16 Member, ROP committee, NNF Karnataka Consultant Neonatologist St. Philomena’s Hospital, Bengaluru, India Satish Ghanta, MD (Paed) Manipal Neonatal Fellowship (Sydney, Aus) Bayley Scales Accredited Developmental Pediatrics (Sydney, Aus) Pediatric & Cardiac Intensive Care Fellowship (Sydney, Aus) Director, Neonatal & Pediatric Intensive Care Services Little Stars Children’s Hospital, Hyderabad Niranjan Thomas, MD, DCH, DNB Professor & Head, Department of Neonatology Christian Medical College (CMC) Vellore, Tamil Nadu, India Copyright and Photocopying All rights reserved. No part of this publication may be reproduced, stored or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording or any information storage and retrieval system, without permission in writing from the chief scientific editor of the book. Disclaimer The publisher and the chief scientific editor cannot be held responsible for errors or any consequences arising from the use of information contained in this book, the views and opinions expressed do not necessarily reflect those of the publisher or chief scientific editor. Kedar Sawleshwarkar, MBBS,MD Director NICU, Deogiri Children’s Hospital, Aurangabad Formerly Associate Professor, Govt Medical College, Aurangabad National Faculty NRP India National Instructor: FBNC Program (NNF-UNICEF) 2014 President IAP Aurangabad 2015 Sudip Dutta, MD Professor & HOD Department of Pediatrics Sikkim Manipal Institute of Medical Sciences Gangtok, Sikkim, India S P Senthil Kumar, M.D. (PAED) Fellowship Pediatric Critical Care Consultant Pediatric Intensivist, Department of Neonatology & Pediatrics Columbia Asia Hospital, Bangalore National Faculty: NNF-IAP Advanced NRP 2010 Scientific Coordinators Sanjay Wazir, MD, DM Neonatology (PGI Chandigarh) Director: Neonatology Cloudnine Hospitals, Gurgaon (NCR), India National Faculty: NNF-IAP Advanced NRP 2010 Rakesh Tiwari, MD, MBA (HCA) Consultant, Department of Neonatology & Pediatrics DSC Team, Mother & Child Unit Paras Hospitals, Gurgaon (NCR), India Shalabh Garg, MD FRCPCH PGClR Consultant Neonatologist James Cook University Hospital Middlesbrough, UK Ajay Lal, Fellowship Neonatology (NNF, India), DCH Medical Director Lal Superspeciality Hospital “Institute of Newborn Sciences” Gurugram (NCR) India Dr Sandeep S Patil, MBBS, MD (Pediatrics) DM(Neonatology), Fellow PCCM(ISCCM) Director CARE Advanced Neonatal Center Nanded, Maharashtra Arnab Sengupta, BDS, MDS (Pedodontics) BLS Certified from AHA (American Heart Association) Director KIDZ Dental Centre Gurgaon (NCR), India Advisor, Pediatric Dental Sciences DSC Foundation (India)