The document summarizes information about water vapor in Earth's atmosphere and its impact on infrared astronomy observations from airborne observatories like SOFIA. It discusses how most water vapor is contained below the troposphere. Weather balloon data and atmospheric models are used to calculate water vapor loading at different altitudes and locations to help determine SOFIA's optimal flight paths for observations. The document presents results comparing water vapor loading estimates from the GEOS-5 atmospheric model to actual sounding data from Wyoming at altitudes of 11.5 km, 13.1 km, and above SOFIA's flying range.