Scalability is the new black
Scalability is a desirable property of a system, a network, or a process, which indicates its ability to either handle growing amounts of work in a graceful manner or to be enlarged. What is scalability? -Wikipedia
Pressflow The performance “aware” and scalable  fork of Drupal
Pressflow Pros Drops support for old PHP versions  ( < 5.2 )
Better  session   handling
Reverse  Proxy   support More info: https://wiki.fourkitchens.com/display/PF/Comparison+-+Pressflow+versus+Drupal
Pressflow Cons Less users => less feedback => more unpredictable behavior
Delay between corresponding prefflow forks and vanilla Drupal
Patch compatibility is not 100% guaranteed
Pressflow Should I use Pressflow? Yes
if you need the features of PF
Pressflow Should I use Pressflow? Yes
if you need the features of PF
No
if you are afraid of experimental and 3 rd  party code for the site
seixorP esreveR What is it? Α Gate keeper / intermediary for incoming requests. Should be able to handle multiple backends with active load balancing. Can act as a caching frontend and a buffer for slow clients.
Reverse Proxies Notable examples Apache 2 – with modules
Squid – most used proxy
Varnish – mostly used with Drupal sites
Nginx – http and proxy server in one
Varnish Pros Highly recommended from most of the people within the Drupal community
Almost out of the box compatibility with Pressflow (and Drupal 7)
Surpassed only by nginx with a very small margin

Drupal and Varnish Reverse Proxy