This document provides an overview of the general approach to pediatric toxicology. It discusses the key steps in management including resuscitation, risk assessment, supportive care, decontamination, enhanced elimination, and use of antidotes. Resuscitation is the top priority and involves establishing an airway and supporting circulation and disability. A thorough history and physical exam are important for risk assessment. Supportive care focuses on observation, hydration, nutrition, and treating specific symptoms. Decontamination methods like skin washing and gastric lavage are limited. Activated charcoal and whole bowel irrigation may be used in select cases. Enhanced elimination includes activated charcoal, alkalinization, and dialysis. Specific antidotes are used