These slides use concepts from my (Jeff Funk) course entitled Biz Models for Hi-Tech Products to analyze the business model for 23andMe’s personal genomics service. 23andMe provides personal health care analysis and ancestry information to individuals that are based on a partial analysis of an individual’s DNA data. Driven by the falling cost of DNA sequencing, 23 and Me provides this information for $99 and a small amount of saliva. While this business model may succeed particularly if the FDA eventually approves the health care portion of the service, we recommend that 23andMe develop a new business model. It should offer the service for free to individuals, particularly those who frequent gyms and nutrition stores and sell information about potential athletes to sports teams.
Why genomics needs telehealth to succeed - Lisa Alderson, Genome Medical - TFSSVSee
Genomics has the potential to revolutionize the practice of medicine by individualizing health care based on an exact knowledge of one's genetic predispositions. Learn why there is currently no sustainable business model to allow for this and how telehealth could be the first step to making personal genomics a part of everyday health care - from the Telehealth Failures & Secrets To Success Conference: vsee.com/telehealth-failures-conference
These slides use concepts from my (Jeff Funk) course entitled Biz Models for Hi-Tech Products to analyze the business model for 23andMe’s personal genomics service. 23andMe provides personal health care analysis and ancestry information to individuals that are based on a partial analysis of an individual’s DNA data. Driven by the falling cost of DNA sequencing, 23 and Me provides this information for $99 and a small amount of saliva. While this business model may succeed particularly if the FDA eventually approves the health care portion of the service, we recommend that 23andMe develop a new business model. It should offer the service for free to individuals, particularly those who frequent gyms and nutrition stores and sell information about potential athletes to sports teams.
Why genomics needs telehealth to succeed - Lisa Alderson, Genome Medical - TFSSVSee
Genomics has the potential to revolutionize the practice of medicine by individualizing health care based on an exact knowledge of one's genetic predispositions. Learn why there is currently no sustainable business model to allow for this and how telehealth could be the first step to making personal genomics a part of everyday health care - from the Telehealth Failures & Secrets To Success Conference: vsee.com/telehealth-failures-conference
Presentation for teaching faculty about resources, data, issues, and strategies for including personal genomics in the classroom, within the context of precision medicine as an overarching theme.
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Global Medical Cures™ | Genetic Testing Handbook
DISCLAIMER-
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From Genomics to Medicine: Advancing Healthcare at ScaleDatabricks
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An Opportunity for delegates to know how much they really know / need to know . The first person who answers a question correctly will get a prize. 30 Minutes of action
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A comprehensive collection of our autoimmunity research done in an effort to help bridge the gap for the large and growing needs of the autoimmune community. This bibliography is a sneak peak at an upcoming white paper for the lonely voices of autoimmune disease.
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DIYgenomics: an open platform for citizen scienceMelanie Swan
DIYgenomics (www.DIYgenomics.org) is a new platform bringing citizen scientists together to run peer cohort research studies and conduct novel research linking genetic data and physical biomarkers. Some norms are developing in response to the variety of community-based research issues that arise such as adaptive studies, informed consent, security, anonymity, and study design.
Presentation on knowledge synthesis methodologies with a focus on engineering, for University of Michigan, October 25, 2023. Overview of the broader context, then focuses in on systematic reviews and tech mining.
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Biology evolved to be just good enough to survive and genomics provides the critical next-generation toolkit for its greater exploitation. Genomics is already starting to be medically actionable and is likely to become increasingly useful over time. This presentation discusses how your genetic information is already useful today,
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In this lesson, students will learn to use bioinformatics portals and tools to mine plant versions of human genes. Student handout and teacher resource materials are available at www.Araport.org, Teaching Resources (Community tab). Suitable for grades 9-12 or first year undergraduate students.
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With the exponential growth of genomic data sets, healthcare practitioners now have the opportunity to improve human outcomes at an unprecedented pace. These outcomes are difficult to realize in the existing ecosystem of genomic tools, where biostatisticians regularly chain together command-line interfaces based on a single-node setup on premise. The Databricks Unified Analytics Platform for Genomics empowers users to perform end-to-end analysis on our massively scalable platform in the cloud: in only minutes, a data scientist can visualize an individual’s disease risk based on their raw genomic data. Built on Apache Spark, we provide click-button implementations of accepted best practice workflows, as well as low-level Spark SQL optimizations for common genomics operations.
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Latest Findings
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Data and Digital Tools
Causes of Autoimmune Disease
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DIYgenomics: an open platform for citizen scienceMelanie Swan
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4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
1. DNA? — an exploration
of 23andMe for health
PF Anderson, Emerging Technologies Informationist,
Taubman Health Sciences Library, University of Michigan
November 11, 2016
2. My personal genomics story
in 25 words or less
BEFORE
● Doctor(s): Tell me where it hurts.
● Me: EVERYWHERE. And ...
● Doctor(s): How long have you hurt?
● Me: 20 years? Forever?
● Doctor(s): It’s probably in your head.
AFTER
What worked? gluten-free diet + new vitamins + exercise
<http://www.slideshare.net/perplexity/celiac-hidden-stories-invisible-disabilities>
4. What is personal genomics?
Individual vs. population
<http://www.nature.com/gim/journal/v11/n
8/full/gim200978a.html>
Genetics (heredity) vs genomics (functions &
interactions)
<http://www.who.int/genomics/geneticsVSg
enomics/en/>
Image credits: <https://openclipart.org/detail/181150/shadow-of-person-standing-leg-cross-and-put-hands-in-the-pockets> |
<https://openclipart.org/detail/46141/group-of-people>
8. And then there’s UM’s “Genes for Good” (FREE!)
● “Genes for Good is a research study
conducted at the University of
Michigan.
● The major goal of the study is to
engage tens of thousands of
individuals in genetic research.
● The primary tool to accomplish this is
the Genes for Good Facebook App.”
<https://genesforgood.sph.umich.edu/> |
<https://genesforgood.sph.umich.edu/face
book_app>
11. What personal
genomics CAN’T
do
“*Our tests can be used to determine carrier
status in adults from saliva collected using an
FDA-cleared collection device (Oragene DX model
OGD.500.001), but cannotdetermine if you
have two copies of the genetic variant. Each test
is most relevant for people of certain ethnicities.
The tests are notintended to diagnose a
disease, or tell you anything about your risk for
developing a disease in the future. On their own,
carrier status tests are notintended to tell you
anything about the health of your fetus, or your
newborn child’s risk of developing a particular
disease later in life.” 23andMe,
<https://customercare.23andme.com/hc/en-us/a
rticles/212194308-Health-Reports-and-Ethnicity>
12. Why not?
Personal genomics tends to “cherry pick” genes to
examines throughout the entire “orchard” of the
genome.
Clinical genomics take more of an “apple
harvesting” comprehensive deep dive into the
products of a single “tree.”
Image credits: <https://commons.wikimedia.org/wiki/File:Cherry_picking_201127_(5991855207).jpg> |
<https://commons.wikimedia.org/wiki/File:Apple_Harvest_by_Camille_Pissarro.jpg>
14. Our genes are like a score …
They tell us what notes are intended.
Image credits: <https://commons.wikimedia.org/wiki/File:Codons_aminoacids_table.png> |
<https://commons.wikimedia.org/wiki/File:Johann_Sebastian_Bach_-_BWV_Anh._117a_-_Polonaise_in_F_major.pdf>
15. … but they can’t tell us how good the piano is,
or how recently it was tuned, …
Image credits: <https://commons.wikimedia.org/wiki/File:The_Honky_Tonk_Blues_-_geograph.org.uk_-_1625960.jpg> |
<https://commons.wikimedia.org/wiki/File:Steinway_%26_Sons_concert_grand_piano,_model_D-274,_manufactured_at_Steinway%27s_factory_in_Hambu
rg,_Germany.png>
16. … or who is playing, or where, or …
Image credits: <https://commons.wikimedia.org/wiki/File:Student_of_House_of_Piano_Music_Academy.JPG> | Hans Bernhard (Schnobby): Oscar Peterson
Plays Piano <https://commons.wikimedia.org/wiki/Oscar_Peterson#/media/File:Oscar_Peterson_1.JPG> |
<https://commons.wikimedia.org/wiki/File:Arthur_Rubinstein_1906.jpg>
18. You get clues, to take to a detective
Clues or hints to health puzzles or
mysteries
Image credits: <https://commons.wikimedia.org/wiki/Sherlock_Holmes#/media/File:Basil_Rathbone_Sherlock_Holmes.jpeg> |
<https://commons.wikimedia.org/wiki/File:Cluedo_Game_Board.jpeg>
19. Finding Your Detectives!
Family Physicians:
<http://familydoctor.org/familydoctor/en.html>
Genetic Counselors: <http://www.nsgc.org/>
Genetics Home Reference <https://ghr.nlm.nih.gov/>
And (with caution) patient or public forums like
Patients Like Me and 23andMe, as well as
disease-specific patient forums.
20. Are there any
risks?
Image credits: <https://openclipart.org/detail/10970/prohibition1> | <https://openclipart.org/detail/10972/prohibition2> |
<https://openclipart.org/detail/10974/prohibition3> | <https://openclipart.org/detail/10976/prohibition4> | <https://openclipart.org/detail/10978/fire-forbidden-sign> |
<https://openclipart.org/detail/10980/prohibition6> | <https://openclipart.org/detail/10982/prohibition7> | <https://openclipart.org/detail/10984/prohibition8>
21. Risks of personal genomics
Finding out something you don’t want to
know
Misunderstanding / misinterpreting what
you find out
Other people finding out something you
don’t want them to know (employers,
insurance, friends, family)
Discovering relatives you don’t know about
Being discovered BY relatives you don’t
know about
Genetics, a double-edged sword
<https://raceandtechnology.wordpress.com/2014/
12/10/genetics-a-double-edged-sword-2/>
GINA - Genetic Information Nondiscrimination Act
<https://www.eeoc.gov/laws/types/genetic.cfm>
33. 23andMe: 3rd Party Tools
23and You: <http://www.23andyou.com/3rdparty>
ISOGG: Autosomal DNA Tools: <http://isogg.org/wiki/Autosomal_DNA_tools>
A few of my (FREE) favorites:
● GEDmatch: <http://gedmatch.com/>
● Genetic Genie: <http://geneticgenie.org/>
● Promethease: <http://snpedia.com/index.php/Promethease>
● David Pike's DNA Comparison Utilities:
<http://www.math.mun.ca/~dapike/FF23utils/>
● Interpretome: <http://esquilax.stanford.edu/>
Not free:
● Strategene <http://go.strategene.org/genetic-analysis/>
35. Doctors can react in different ways …
OMG, it’s a real genetic test!
Wow! Let’s change all your
meds!
OMG, it’s a
personal
genomic
test. Not
another
one! I
don’t have
time for
this.
OMG, it’s a real genetic
test! Wow! Let’s
change all your meds!
OMG, it’s a personal genomic
test. Not another one! I don’t
have time for this.
36. Best is
something
like this —>
Not this —> OMG! (too much
action, too little data)
Or this —> OMG! (not enough
action, not enough conversation
about why it’s important to you)
Hmmmm. Well, this is interesting,
and while it really doesn’t tell us
anything definitive yet, it does
suggest some areas we might
want to explore. Let’s talk more.
Would you be willing to have some
more tests? Or see a genetic
counselor? I’m thinking of …
37. More
information &
resources
● DIYgenomics: <http://www.diygenomics.org/index.php>
● DNA.Land: <https://dna.land/>
● Genetics Home Reference (NIH):
<https://ghr.nlm.nih.gov/>
● GeneKnot: <https://geneknot.com/>
● Genomes Unzipped: <http://genomesunzipped.org/>
● Infinome: <https://www.infino.me/welcome>
● Patients Like Me: <https://www.patientslikeme.com/>
● Your Genome: <http://www.yourgenome.org/>