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Diverticulums-Bowel cancer
              Clínicas quirúrgicas
          Dr. Héctor Manuel Virgen Ayala
           Dr. Benjamin Robles Mariscal

   Ponente: Héctor Eduardo Velázquez Domínguez
Diverticulums




  http://www.medicinapratica.com.br/tag/diverticulo/
Type

Congenital          Meckel (2%)



                Jejunum/Ileum 15%
Acquired
                    Colon (50%)
Pathologies

• Diverticular disease (symphtomatic
  diverticulum)
• Diverticulosis (diverticulum without
  inflamation)
• Diverticulitis (inflamation and infection)
Meckel diverticulum
•   2%

•   M 3:2 F

•   Congenital real
    diverticulum

•   Faulty onfalomesenteric
    duct obliteration

•   Ileum-1m ileocecal valve
                               http://www.pedsurg.com.pe/El_diverticulo_de_meckel.php
Faulty onfalomesenteric duct obliteration




             http://scielo.sld.cu/img/revistas/rpr/v9n1/f0111105.jpg
Cells

                            • Gastric (60%)
                            • Pancreas
60% heterotopic mucosa
                            • Brunner glands
                            • Colon
                            • Endometrial
                            • Hepatobiliary
Clinical presentation

•   Usually asymptomatic

•   4% complications (50%
    <10 â)

•   Appendicitis like!



                            http://www.aurorahealthcare.org/yourhealth/healthgate/
                               getcontent.asp?URLhealthgate=%22127569.html%22
Complications
 SCHWARTZ PRINCIPIOS DE CIRUGIA (8ª ED.) BRUNICARDI, F.
     MCGRAW‐HILL / INTERAMERICANA DE MEXICO


                                                             •   Hemorrhage (50% <18â)

                                                             •   Diverticulitis (more
                                                                 common in adults)

                                                             •   Obstruction

                                                             •   Perforation

                                                             •   Volvulus

                                                             •   Intussusception
http://www.revistahnrg.com.ar/pdf_contenidos/con194‐89.pdf
http://www.elsevier.es/sites/default/ciles/elsevier/images/288/288v73n04/grande/288v73n04‐13149799cig1.jpg
Acquired diverticulum

• False diverticulum
• Duodenum near the ampulla
• Jejunum-big and multiple
• Ileum-small and solitary
• Colon (sigmoid)-between tenias/vessels
Jejunum/ileum
         diverticulum
• 56-76 â
• Traction, muscular weakness and bacteria
• 6-10% symphtomatic
• Intermittent pain, flatulence, diarrhea
  (10-30%)
• Same complications as Meckel
• Duodenal: compression choledocus or
  Wirsung
Colon diverticulum
• >50 â (50%)
• Pulsion, low fiber
• most are asymphtomatic
• Left side pain
• Fieber, leukocytosis
• Same complications as Meckel
Dx/Tx
•   Enteroclysis       •      Diverticulectomy

•   Endoscopy          •      Segmental resection

•   Barium enema

•   Qx




                      SCHWARTZ PRINCIPIOS DE CIRUGIA (8ª ED.) BRUNICARDI, F.
                          MCGRAW‐HILL / INTERAMERICANA DE MEXICO
http://www.youtube.com/watch?v=9S1Xn0Kk4kY
Polyposis
http://mingaonline.uach.cl/scielo.php?pid=s0718‐28642007000100009&script=sci_arttext
Classification
• Neoplasic
• Hamartomatous (youth)            Sessile
• Inflammatory                   Pedunculated
• Hyperplastic

• ¡Most of carcinomas evolve from polyps!
Neoplasic
                                                         http://www.boloncol.com/images/stories/boletin15/colon3.jpg




•   Villous adenoma (40%)

•   Tubulovillous adenoma
    (22%)

•   Tubular adenoma (5%)




               http://escuela.med.puc.cl/publ/patologiageneral/patol_097.html
Hamartomatous

                                                                                          •      Rarely premalignant

                                                                                          •      Familiar juvenile
                                                                                                 polyposis (colon and
                                                                                                 rectum)

                                                                                          •      Peutz-Jeghers syndrome
                                                                                                 (small intestine, less
                                                                                                 colon and rectum)

http://www.ngoaikhoathuchanh.info/vn/chitiettintuc.aspx?IDTT=1042011113514&IDLOAI=266201002348
Inherited cancer

•   Familiar adenomatous
    polyposis (100%)

•   Lynch syndrome (no
    polyps)



                           http://www.elsevier.es/sites/default/ciles/elsevier/images/
                           288/288v74n04/grande/288v74n04‐13147781cig1.jpg
Jejunum and ileum
      cancer
Statistics
• 1.5%              • 80% metastasis
 gastrointestinal    at diagnosis
 tract tumor
                    • 25% 5 year
• 10%                survival
 symptomatic
 (75% malign)       • 5th-6th decade
http://www.mdsaude.com/
                                   http://www.gastrointestinalatlas.com/   http://emedicine.medscape.com/article/179284‐overview
2010/07/polipos‐intestinais.html




                  • Adenocarcinoma                                               35-50%

                  • Carcinoid tumor                                             20-40%

                  • Lymphoma                                                   10-15%

                  • GIST                                                        10-15%
Risk factors
•   Red meat

•   Smoked food

•   Crohn disease

•   Celiac sprue

•   Polyps

•   FAP

•   Lynch syndrome           http://www.cocinerosonline.com/blog/?page_id=499




•   Peutz-Jeghers syndrome
Clinical
presentation
       Asymptomatic
Parcial or total obstruction
            (25%)
   Palpable mass (25%)
  Colicky abdominal pain
         Distension
   Nausea and vomiting
        Hemorrhage
                               http://milennium.net/aikiblog/wp‐content/uploads/2010/09/dolor‐abdomen.jpg
Diagnosis

                                                         •   Enteroclysis

                                                         •   Endoscopy

                                                         •   Endoscopy capsule

                                                         •   5-HIAA (carcinoid
                                                             tumor)

SCHWARTZ PRINCIPIOS DE CIRUGIA (8ª ED.) BRUNICARDI, F.
    MCGRAW‐HILL / INTERAMERICANA DE MEXICO
http://www.portalesmedicos.com/publicaciones/articles/889/2/




Treatment                                     resection
Colon cancer
Statistics
• Most            • 5th-6th decade
 common GI         of life

• 95%             • PAF and CCHSP
 Adenocarcinoma    (20%)
Location
Risk factors

• Same as jejunum and ileum cancer
• Smoking and alcohol                AINE
• Poor fiber intake                Vitamin D
• High saturated fat intake        Excersise
Symptoms
                   • Right colon:
• Left colon:        Weakness
  Changes in         Anemia
  bowel habits       Hidden blood in
  Blood in stool     stool
  Obstructive        Dispeptic
  symptoms           symptoms
                     Right disconfort
                     Palpable mass
Laboratory
    tests
       Urinalysis
CBC (biometría hemática)
Carcinoembryonic antigen
         (ACE)
         70% colon Cancer
 detect recurrences after resection
Radiology
                                                                                 Rx
                                                                           Barium enema
                                                                            Colonoscopy
                                                                                TAC
                                                                           Sigmoidoscopy
                                                                        Endorectal ultrasound


http://hnsebimagenes.blogspot.com/2009/01/cncer‐de‐colon‐derecho.html
Treatment

         Resection

           Paliative
       Electrocoagulation
    Fotocoagulation with laser
       Splints-endoferulas

Adjuvant and neoadjuvant therapy
        Radio and quimio
Staging: TNM
http://www.youtube.com/watch?v=hycQvTO0C24
Thanks

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Diverticulums - Bowel cancer

  • 1. Diverticulums-Bowel cancer Clínicas quirúrgicas Dr. Héctor Manuel Virgen Ayala Dr. Benjamin Robles Mariscal Ponente: Héctor Eduardo Velázquez Domínguez
  • 3. Type Congenital Meckel (2%) Jejunum/Ileum 15% Acquired Colon (50%)
  • 4. Pathologies • Diverticular disease (symphtomatic diverticulum) • Diverticulosis (diverticulum without inflamation) • Diverticulitis (inflamation and infection)
  • 5. Meckel diverticulum • 2% • M 3:2 F • Congenital real diverticulum • Faulty onfalomesenteric duct obliteration • Ileum-1m ileocecal valve http://www.pedsurg.com.pe/El_diverticulo_de_meckel.php
  • 6. Faulty onfalomesenteric duct obliteration http://scielo.sld.cu/img/revistas/rpr/v9n1/f0111105.jpg
  • 7. Cells • Gastric (60%) • Pancreas 60% heterotopic mucosa • Brunner glands • Colon • Endometrial • Hepatobiliary
  • 8. Clinical presentation • Usually asymptomatic • 4% complications (50% <10 â) • Appendicitis like! http://www.aurorahealthcare.org/yourhealth/healthgate/ getcontent.asp?URLhealthgate=%22127569.html%22
  • 9. Complications SCHWARTZ PRINCIPIOS DE CIRUGIA (8ª ED.) BRUNICARDI, F. MCGRAW‐HILL / INTERAMERICANA DE MEXICO • Hemorrhage (50% <18â) • Diverticulitis (more common in adults) • Obstruction • Perforation • Volvulus • Intussusception http://www.revistahnrg.com.ar/pdf_contenidos/con194‐89.pdf
  • 11. Acquired diverticulum • False diverticulum • Duodenum near the ampulla • Jejunum-big and multiple • Ileum-small and solitary • Colon (sigmoid)-between tenias/vessels
  • 12. Jejunum/ileum diverticulum • 56-76 â • Traction, muscular weakness and bacteria • 6-10% symphtomatic • Intermittent pain, flatulence, diarrhea (10-30%) • Same complications as Meckel • Duodenal: compression choledocus or Wirsung
  • 13. Colon diverticulum • >50 â (50%) • Pulsion, low fiber • most are asymphtomatic • Left side pain • Fieber, leukocytosis • Same complications as Meckel
  • 14. Dx/Tx • Enteroclysis • Diverticulectomy • Endoscopy • Segmental resection • Barium enema • Qx SCHWARTZ PRINCIPIOS DE CIRUGIA (8ª ED.) BRUNICARDI, F. MCGRAW‐HILL / INTERAMERICANA DE MEXICO
  • 18. Classification • Neoplasic • Hamartomatous (youth) Sessile • Inflammatory Pedunculated • Hyperplastic • ¡Most of carcinomas evolve from polyps!
  • 19. Neoplasic http://www.boloncol.com/images/stories/boletin15/colon3.jpg • Villous adenoma (40%) • Tubulovillous adenoma (22%) • Tubular adenoma (5%) http://escuela.med.puc.cl/publ/patologiageneral/patol_097.html
  • 20. Hamartomatous • Rarely premalignant • Familiar juvenile polyposis (colon and rectum) • Peutz-Jeghers syndrome (small intestine, less colon and rectum) http://www.ngoaikhoathuchanh.info/vn/chitiettintuc.aspx?IDTT=1042011113514&IDLOAI=266201002348
  • 21. Inherited cancer • Familiar adenomatous polyposis (100%) • Lynch syndrome (no polyps) http://www.elsevier.es/sites/default/ciles/elsevier/images/ 288/288v74n04/grande/288v74n04‐13147781cig1.jpg
  • 23. Statistics • 1.5% • 80% metastasis gastrointestinal at diagnosis tract tumor • 25% 5 year • 10% survival symptomatic (75% malign) • 5th-6th decade
  • 24. http://www.mdsaude.com/ http://www.gastrointestinalatlas.com/ http://emedicine.medscape.com/article/179284‐overview 2010/07/polipos‐intestinais.html • Adenocarcinoma 35-50% • Carcinoid tumor 20-40% • Lymphoma 10-15% • GIST 10-15%
  • 25. Risk factors • Red meat • Smoked food • Crohn disease • Celiac sprue • Polyps • FAP • Lynch syndrome http://www.cocinerosonline.com/blog/?page_id=499 • Peutz-Jeghers syndrome
  • 26. Clinical presentation Asymptomatic Parcial or total obstruction (25%) Palpable mass (25%) Colicky abdominal pain Distension Nausea and vomiting Hemorrhage http://milennium.net/aikiblog/wp‐content/uploads/2010/09/dolor‐abdomen.jpg
  • 27. Diagnosis • Enteroclysis • Endoscopy • Endoscopy capsule • 5-HIAA (carcinoid tumor) SCHWARTZ PRINCIPIOS DE CIRUGIA (8ª ED.) BRUNICARDI, F. MCGRAW‐HILL / INTERAMERICANA DE MEXICO
  • 30. Statistics • Most • 5th-6th decade common GI of life • 95% • PAF and CCHSP Adenocarcinoma (20%)
  • 32. Risk factors • Same as jejunum and ileum cancer • Smoking and alcohol AINE • Poor fiber intake Vitamin D • High saturated fat intake Excersise
  • 33. Symptoms • Right colon: • Left colon: Weakness Changes in Anemia bowel habits Hidden blood in Blood in stool stool Obstructive Dispeptic symptoms symptoms Right disconfort Palpable mass
  • 34. Laboratory tests Urinalysis CBC (biometría hemática) Carcinoembryonic antigen (ACE) 70% colon Cancer detect recurrences after resection
  • 35. Radiology Rx Barium enema Colonoscopy TAC Sigmoidoscopy Endorectal ultrasound http://hnsebimagenes.blogspot.com/2009/01/cncer‐de‐colon‐derecho.html
  • 36. Treatment Resection Paliative Electrocoagulation Fotocoagulation with laser Splints-endoferulas Adjuvant and neoadjuvant therapy Radio and quimio