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Protein Interaction Graph
Protein Interaction
A protein interaction in a living cell occurs
when two or more proteins in that cell bind to perform a
biological function.
Protein interactions within a cell can be modelled by using a
protein interaction graph (also called a protein–protein
interaction network).
It has undirected graph
A protein–protein interaction network is an undirected graph.
In which each protein is represented by a vertex, with an edge
connecting the vertices representing each pair of proteins that
interact.
Usage:
Protein interaction graphs can be used to deduce important
biological information.
For Example:
Identifying the most important proteins for
various functions and the functionality of newly discovered
proteins
There are thousands of different proteins in a typical cell, so
that’s why protein interaction graph of a cell is extremely
large and complex.
For Example:
Human cells have more than 100,000 proteins, with
perhaps as many as 1,000,000 interactions between them.
Because of the complexity they are often split into smaller
graphs called ‘Modules’ that represent the groups of proteins
that are involved in a particular function of a cell.
Figure 12 illustrates a module of the protein interaction graph
described in [Bo04], comprising the complex of proteins that
degrade RNA in human cells.
To learn more about protein interaction graphs ,see[Bo04],
[Ne10], and [Hu07].

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Protein Interaction Graph

  • 1. Protein Interaction Graph Protein Interaction A protein interaction in a living cell occurs when two or more proteins in that cell bind to perform a biological function. Protein interactions within a cell can be modelled by using a protein interaction graph (also called a protein–protein interaction network).
  • 2. It has undirected graph A protein–protein interaction network is an undirected graph. In which each protein is represented by a vertex, with an edge connecting the vertices representing each pair of proteins that interact.
  • 3. Usage: Protein interaction graphs can be used to deduce important biological information. For Example: Identifying the most important proteins for various functions and the functionality of newly discovered proteins
  • 4. There are thousands of different proteins in a typical cell, so that’s why protein interaction graph of a cell is extremely large and complex. For Example: Human cells have more than 100,000 proteins, with perhaps as many as 1,000,000 interactions between them.
  • 5. Because of the complexity they are often split into smaller graphs called ‘Modules’ that represent the groups of proteins that are involved in a particular function of a cell. Figure 12 illustrates a module of the protein interaction graph described in [Bo04], comprising the complex of proteins that degrade RNA in human cells.
  • 6. To learn more about protein interaction graphs ,see[Bo04], [Ne10], and [Hu07].