Digital Nutrition
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Michael Phillips Moskowitz, Founder/CEO of AeBeZe Labs and Moodrise, on the topic of 'Digital Nutrition' at IFAH held at Le Meridien, Dubai on 16th - 18th December, 2019.
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Digital Nutrition
- 1. KEYNOTE ™
- 2. Today, at least 300M people are clinically depressed. An even greater number suffer from mild to moderate symptoms, and go untreated. More than half of adults suffering from mental illness do not receive help Source: The Common Wealth Fund, 2018 Scorecard on State Health System Performance FACT December 2019 Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 3. FACT *Source: Center for Human Technology The number of Facebook users that report feeling worse after each use* December 2019 Grindr WeChat 77% 62% Candy Crush Reddit 71% 58% Facebook Instagram SnapChat 64% 51% 50% The world’s “most popular” apps are actually making people depressed. Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 4. FACT December 2019 In 2020, nearly 800K people will take their own lives–one person, every 40 seconds. That’s a city the size of Seattle erased, before next New Year’s Eve. Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 5. Our (current) digital diets impact and undermine mental health. THE PROBLEM Source: https://www.emarketer.com/Article/US-Adults-Now-Spend-12-Hours-7-Minutes-Day-Consuming-Media/1015775 Average time adults spend, consuming digital material every daily IN AMERICA December 2019 But we can leverage media to improve behavioral wellbeing. Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 6. ™ December 2019 Media is malady Media is medicine Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 7. December 2019 The Shawshank Redemption (1994) Dopamine Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 8. December 2019 Usain Bolt, 100m world record (2009) Endorphins Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 9. December 2019 Raccoon, in a log (2015) Oxytocin Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 10. December 2019 Crazy in Love (2011) Dopamine / Endorphins Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 11. ™ December 2019 FACT Content can alter the way you feel. It just did. Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 12. ™ December 2019 IMAGINE What if we applied this principle to behavioral health and wellbeing? We have. Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 15. THE DEMAND December 2019 Single songs dwarf single downloads by wide margins. Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 16. THE OPPORTUNITY December 2019 But Pharma’s market cap dwarfs the entire music industry by And pharma-ceuticles represent a massive new frontier of growth Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 17. THE OPPORTUNITY December 2019 Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 18. Global music sales grew 9.7% in 2018, reaching $19.1 billion in total revenue. It was the fourth consecutive year of growth and the highest rate since the IFPI began tracking the market in 1997. Nearly half (47%) of all revenue came from streaming, which grew by 34% in 2018. THE NUMBERS December 2019 MUSIC INDUSTRY The global pharmaceuticals market was worth $934.8 billion in 2017 and will reach $1.17 trillion in 2021, growing at 5.8% annually, according to pharma market research reports. PHARMA HIGH LIFE Digital drugs represent the next frontier of Rx medicine and personal entertainment. Someday, the FCC will be as important as the FDA. Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 19. THE SOLUTION Mood-elevating e-remedies, supported by clinical research, that use digital tools to enhance emotional resilience. + Hijack consumer behavior, shifting depleting addictions ( - ) into re-pleting ( + ) behaviors + Use data and digital intelligence to safeguard mental health—create a first aid kit, for emotional distress + Offer simpler, safer, cheaper therapies—delivered byte by byte—to help people cope with stress, loneliness and disconnection + Create an entirely new standard in content creation and standardized measurements of Digital Nutrition™ December 2019 Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 20. FUTURE OF THE ALBUM December 2019 Moodrise + AeBeZe Labs Pioneering Digital Nutrition Disrupt the medicine aisle–and the entire music industry–with digital drugs, in physical form. Music as medicine. Generate revenue through sales of healthful, physical inventory and objects at highly trafficked shopping locations..
- 21. Moodrise focuses on the six (6) most important chemicals that govern mood. TREATMENT TYPES + BENEFITS To aid with concentration and focus To boost self-confidence To elevate energy levels To deliver a sense of calm, and relieve stress To replenish the bonding and love molecule To establish a firm foundation for happiness December 2019 Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 22. PROOF & PATENTS Like the body, your mood can be trained and fine tuned. We utilize a combination of clinical research, curated content, and simple tracking to monitor, boost, and maintain higher mood. December 2019 Believe the evidence. SUPPORTING SCIENCE Batra, S., Baker, R. A., Wang, T., Forma, F., DiBiasi, F., & Peters-Strickland, T. (2017). Digital health technology for use in patients with serious mental illness: a systematic review of the literature. Medical Devices (Auckland, N.Z.), 10, 237–251. https://doi.org/10.2147/MDER.S144158 Tal, A., & Torous, J. (2017). The digital mental health revolution: Opportunities and risks. Psychiatric Rehabilitation Journal, 40(3), 263–265. https://doi.org/10.1037/prj0000285 Ben-Zeev, D., Brian, R., Wang, R., Wang, W., Campbell, A. T., Aung, M. S. H., . . . Scherer, E. A. (2017). CrossCheck: Integrating self-report, behavioral sensing, and smartphone use to identify digital indicators of psychotic relapse. Psychiatric Rehabilitation Journal, 40(3), 266-275. http://dx.doi.org/10.1037/prj0000243 Free, C., Phillips, G., Galli, L., Watson, L., Felix, L., Edwards, P., … Haines, A. (2013). The Effectiveness of Mobile-Health Technology-Based Health Behaviour Change or Disease Management Interventions for Health Care Consumers: A Systematic Review. PLoS Medicine, 10(1), e1001362. https://doi.org/10.1371/journal.pmed.1001362 Menon, V., Rajan, T. M., & Sarkar, S. (2017). Psychotherapeutic Applications of Mobile Phone-based Technologies: A Systematic Review of Current Research and Trends. Indian Journal of Psychological Medicine, 39(1), 4–11. https://doi.org/10.4103/0253-7176.198956 Primack, B. A., Karim, S. A., Shensa, A., Bowman, N., Knight, J., & Sidani, J. E. (2019). Positive and Negative Experiences on Social Media and Perceived Social Isolation. American Journal of Health Promotion, 089011711882419. https://doi.org/10.1177/0890117118824196 MOODRISE PATENTS APP # 15/702,555 STATUS Approved TITLE Method and System for Imposing a Dynamic Sentiment Vector to an Electronic Message DESC Pertains to parsing electronic messages; discerning emotional tone; and imposing a vector _____ APP # 16/282,262 STATUS Filed–21 February 2019 TITLE System and Method for Delivering a Digital Therapeutic from a Parsed Electronic Message APP # 15/959,075 STATUS Filed–20 April 2018 TITLE Delivery of a Digital Therapeutic Method and System APP # 16/159,119 STATUS Filed–12 December 2018 TITLE System and Method for Labeling a Therapeutic Value to Digital Content APP # 16/239,138 STATUS Filed–3 January 2019 TITLE Mood Map for Assessing a Dynamic Emotional or Mental State (dEMS) of a User APP # 16/403,841 STATUS Filed–6 May 2019 TITLE A System and Method for an Audio- Based Digital Therapeutic Delivery Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 23. December 2019 Young, S. N. (2007). How to increase serotonin in the human brain without drugs. Journal of Psychiatry & Neuroscience : JPN, 32(6), 394–399. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/18043763 Lindseth, G., Helland, B., & Caspers, J. (2015). The effects of dietary tryptophan on affective disorders. Archives of Psychiatric Nursing, 29(2), 102–107. https://doi.org/10.1016/j.apnu.2014.11.008"
- 24. ™ December 2019 Guglietti, C. L., Daskalakis, Z. J., Radhu, N., Fitzgerald, P. B., & Ritvo, P. (2013). Meditation-Related Increases in GABAB Modulated Cortical Inhibition. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation. Brain Stimulation, 6(3), 397–402. https://doi.org/10.1016/j.brs.2012.08.005 Song, C., Ikei, H., & Miyazaki, Y. (2018). Physiological effects of visual stimulation with forest imagery. International Journal of Environmental Research and Public Health, 15(2). https://doi.org/10.3390/ijerph15020213
- 25. ™ December 2019 Hennig, J., Laschefski, U., & Opper, C. (1994). Biopsychological changes after bungee jumping: β-endorphin immunoreactivity as a mediator of euphoria? Neuropsychobiology, 29(1), 28–32. https://doi.org/10.1159/000119059 Balchin, R., Linde, J., Blackhurst, D., Rauch, H. L., & Schönbächler, G. (2016). Sweating away depression? the impact of intensive exercise on depression. Journal of Affective Disorders, 200, 218–221. https://doi.org/10.1016/j.jad.2016.04.030
- 26. ™ December 2019 Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012). Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior. Neuron, 76(1), 116–29. https://doi.org/10.1016/j.neuron.2012.08.036 Elvander, E & Schött, PA & Sandin, Johan & Bjelke, Börje & Kehr, Jan & Yoshitake, T & Ogren, Sven. (2004). Intraseptal muscarinic ligands and galanin: Influence on hippocampal acetylcholine and cognition. Neuroscience. 126. 541-57. 10.1016/j.neuroscience.2004.03.058.
- 27. ™ December 2019 Rangel-Gomez, M., & Meeter, M. (2016). Neurotransmitters and Novelty: A Systematic Review. Journal of Psychopharmacology, 30(1), 3–12. https://doi.org/10.1177/0269881115612238 Costa, V. D., Tran, V. L., Turchi, J., & Averbeck, B. B. (2014). Dopamine modulates novelty seeking behavior during decision making. Behavioral Neuroscience, 128(5), 556–566. https://doi.org/10.1037/a0037128
- 28. December 2019 Nagasawa, M., Mitsui, S., En, S., Ohtani, N., Ohta, M., Sakuma, Y., … Kikusui, T. (2015). Oxytocin-gaze positive loop and the coevolution of human-dog bonds. Science, 348(6232), 333–336. https://doi.org/10.1126/science.1261022 Nittono H, Fukushima M, Yano A, Moriya H (2012) The Power of Kawaii: Viewing Cute Images Promotes a Careful Behavior and Narrows Attentional Focus. PLoS ONE 7(9): e46362. https://doi.org/10.1371/journal.pone.0046362
- 29. CURRENT DELIVERY PLATFORMS World’s first on-demand, digital drug delivery system for mobile devices World’s first Pillcast™ platform: mood-enhancing audio segments, delivered in 90-second doses Powerful mood-tracking tools and interactions, designed for the Apple Watch and FitBit December 2019 Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 30. PLATFORM AND PRODUCT EVOLUTION December 2019 JAN FEB MAR APR MAY OCT JAN FEB MAR Season 2 release of the Moodrise 1000 Awards Commence Phase II USAF Partnership* AI training tool integration Modular versions for enterprise Database capable of labelling content USAF / Daybreak Launch Moodrise + AeBeZe Labs Pioneering Digital Nutrition Web app integration for content mark’g and saving Daybreak + Moodrise Podcast New mood- tracker for Apple + FitBit
- 31. FACTS IN FAVOR ** Source: According to a survey by The National Business Group on Health and Fidelity Investments *Source: 2017 estimate by Marketdata Enterprises Meditation apps have helped pave the way Together, Headspace and Calm have secured 38M app downloads and created a $1.2BN market– just for meditation*.Mental health struggles are no longer taboo Global influencers like Prince Harry and professional athletes like Michael Phelps have taken their private struggles public to help widen the dialogue. Legalized cannabis and LSD have changed the game Recent policy changes have triggered a revolution in healthcare treatment options (in and outside of the clinic) as well in law enforcement, culture, and commerce. Today, businesses pay to help employees tap into consciousness–to improve productivity and reduce stress-related healthcare costs About 22% of companies started offering mindfulness meditation training in 2016, and another 21% planned to add it in 2017**. Digital pharma is no longer science fiction The world’s leading drug makers are actively searching for digital solutions to address growing demand in this emerging vertical. ePharma is the next multi-billion dollar opportunity, up for grabs. December 2019 Multiple trends, policy changes, and patterns of behavior are colliding to advance our mission. Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 32. INITIAL AUDIENCE December 2019 U.S. Air Force and clients across the armed services. We’re laser focused on the unmet need in the middle of the market: people with mild to moderate symptoms. Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 33. COMMERCIAL AUDIENCE Recreational Frequent TECH Early Adopters Name: Jen Choi Age: 34 69 Million Americans considered “strong” early tech adopters 10 Million Suffer from mild to moderate health disorders http://www.pewresearch.org/fact- tank/2016/07/12/28-of-americans-are- strong-early-adopters-of-technology/ NUTRITION Bio-Hackers *Using nutrition supplement(s) usage as proxy Name: Stevie Chang Age: 35 170 Million Americans that take dietary supplements 24 Million Suffer from mild to moderate health disorders http://www.crnusa.org/CRN- consumersurvey-archives/2015/ FITNESS Devotees *Using gym membership numbers as proxy Name: Aaron Paul Age: 28 61 Million Americans with active gym memberships (2017) 9 Million Suffer from mild to moderate health disorders https://www.statista.com/statistics/252 933/leading-markets-of-the-health-club- industry-worldwide-by-number-of- members/ MEDIA Bingers *Using Netflix subscribers as proxy Name: Sara Lewis Age: 29 137 Million Netflix subscribers in the U.S. 19 Million Suffer from mild to moderate health disorders https://mashable.com/2017/11/14/netfl ix-public-bingeing/#ipJlRLaQVaqb 12-STEP PROGRAMS Addicts in Recovery * Using NSDUH figures Name: Kris Black Age: 37 24 Million American adults in recovery programs 3 Million+ Suffer from mild to moderate health disorders https://americanaddictioncenters.or g/rehab-guide/addiction-statistics/ December 2019 *Using Pew Research figures Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 34. JUN Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 35. APPENDIX ™
- 36. COMPETITIVE LANDSCAPE DIGITAL PHARMA CONSUMER BEHAVIORAL HEALTH ENTERPRISE December 2019 Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 37. Moodrise is a consumer experience that can quickly grow revenue through enterprise contracts with large self-insured employers (SIEs). GENERATING REVENUE TODAY Nike, Inc. A self-insured employer with 74,000 employees On average pays $20.40* per employee per month for non serious mental health benefits, including: • stress coping education • psychosocial assessment • licensed counseling • employee assistance program • leadership training • financial literacy Comparable Spend Companies also pay, on average, $35** per employee per month for dental benefits. INSIGHT Unused Benefits According to the American Psychological Association Benefit go underutilized within employee plans due to: • stigma of reaching out (53%) • length of treatment (59%) • treatment comprehension (47%) Self insured employers are paying for services that few people use despite need. 60% People’s mental health needs go untreated every year*** VALUE PROP Pay for Use AeBeZe offers employers digital nutrition for $3 PMPM Moodrise provides employers with a mental health management and intervention benefit for its employees: • bundled claims are made every month for only the employees who use Moodrise • the initial contract price is $3 PMPM based on a 25% use rate • future pricing can be adjusted to reflect cost containment goals if employer elects to engage in a benefit performance assessment REVENUE User Bundles Nike can quickly aggregate product access and use With an initial contract price of $3 PMPM and an est. use rate of 25% (to be confirmed in forthcoming pilots), Moodrise will generate (as an example) 2.63 M USD / YR with the Nike, Inc contract alone. Nike’s utilization of Moodrise will not add cost, but compete for the existing $20.40* PMPM with: • discreet on-boarding (stigma) • 90 second e-therapies (duration) • intuitive user experience • self-reporting condition mgmt. • individualized benefit plan prompts SCALED REVENUE Scale User Sales Quickly Through Employer Contract If we contract with 174 companies (or 10% of the self-insured employer market) of similar size to Nike we will generate 500M USD / YR Mass Market Wellness Subscription Model Marketed as a self-care mobile health product direct to consumers. This business model has a high acquisition cost that will be slow to grow. ALTERNATE BUSINESS MODELS Enterprise Productivity Subscription Model Marketed as a productivity product to office and team managers. This business model plays in a highly competitive and saturated market. Healthcare Referral Subscription Model Marketed as a condition-management tool to providers for their patients. This business model has a high cost of entry and subject to broker contract terms. Health Intervention Pay for Use Bundle Model Marketed as an employee benefit to self insured employers/ TPAs. This business model bills employer monthly on actual use and competes directly with existing suite of under-used benefits. ALTERNATE BUSINESS MODELS ** Source: Zenefits, https://www.zenefits.com/blog/what-is-the-average-cost-of-dental-insurance/ *** Source: The Common Wealth Fund, 2018 Scorecard on State Health System Performance *Source: 2017 Milliman Research Report: Potential economic impact of integrated medical-behavioral healthcare December 2019 Moodrise + AeBeZe Labs Pioneering Digital Nutrition
- 38. We’ve assembled a world-class team of operators, advisors, and partners to ensure that we lead the category. TEAM Michael P Moskowitz Founder MSc, London School of Economics Founder of BUREAU OF TRADE, acquired by eBay; FastCompany Top-100 Creatives in Business; EIR @ Foundation Capital 1st Entrepreneurship Fellow @ Harvard Kennedy School Sold 5 companies in last 5 years Beto Lopez Head of R&D MS, Univ. of Texas at Austin Co-Founder, Managing Director at Design Institute for Health, University of Texas at Austin Global Lead, Systems Design @ IDEO Associate Professor of Medical Education, Dell Medical School, University of Texas at Austin Associate Professor of Practice, in the College of Fine Arts, University of Texas at Austin Akshay Dashrath Head of Product MSc, University of York 15 years experience building mobile apps, including: Gumtree, eBay Classifieds Group (Voted in the top 10 apps in the UK in 2015, 2016), at the moment over 14 million downloads; Songkick (when at Novoda), top-25 apps, Time Magazine, 2012; Depop; Collins Bird Guide; ASOS Magazine; Monzo (signup app) Luigi Agosti CTO MA, Polytechnic Univ. of Milan 23 years programming experience, including: Meetup.com (Initial app in 2011); Economist, tablet app, worked with the Google team and Tigerspike to bring the first tablet experience of The Economist to Honeycomb tablets; Daily Mail; Novoda; Burberry; JP Morgan; eBay; Laundrapp CORE TEAM Gloria Kim Lead Curator George Keenan Design Engineer Quentin Le Guennec Lead Developer Juliet Slade Associate Engineer DISTRIBUTED TEAM Noam Cohen Editorial Director PhD Stanford 2008 Ashleigh Golden Clinical Psychologist Stanford PsyD Consortium 2013; American Psychological Association DIV35 Committee on Technology Board Member Matthew Jordan Behavioral Researcher Yale University PhD (2019) SCIENCE ADVISORS Dr. Hans Ringertz Fmr Chairman @ Nobel Prize Committee in Physiology or Medicine Dr. Carrie Barron Professor of Psychology @ Columbia University; Director of Creativity for Resilience Program @ Dell Medical School Dr. Nathan Spreng Associate Professor + Director of the Laboratory of Brain and Cognition @ McGill BUSINESS + PRODUCT ADVISORS Scott Tong Head of Product Design @ Pinterest Co-Founder, IFTTT Emil Michael Former SVP, Uber Co-created $70B+ in market value across 3 companies Dan Bomze Serial Entrepreneur $150M+ in exits Max Simkoff Serial Entrepreneur CEO, States Trust Brad Artziniega Design Lead @ Medium CELEBRITY PARTNERS Dame Kristin Scott Thomas Devendra Banhart JD Samson Waris Ahluwalia INDUSTRY PARTNERS (In conversation with) IFTTT Sony Music Entertainment Universal Music Group Welltok December 2019 Moodrise + AeBeZe Labs Pioneering Digital Nutrition
Editor's Notes
- JULIET: Please recreate the AeBeZe logo in white. We need a high-res version of the AeBeZe logo to keep on file anyway. I just need it placed in the upper-right hand corner. Thanks!
- JULIET 1: Please make this video play on loop, like the previous image: JULIET 2: Please recreate the AeBeZe logo in white. We need a high-res version of the AeBeZe logo to keep on file anyway. I just need it placed in the upper-right hand corner. Thanks!
- Talk about John Borthwick quote: 1850 - 2010: health from the neck down. 1816 – Rene Laennec invents the stethoscope. 1870 – Louis Pasteur and Robert Koch establish the germ theory of disease. 1963 – Artificial heart – Paul Winchell 1985 – DNA fingerprinting – Alec Jeffreys 2000 26 June – The Human Genome Project draft was completed. 2020 and beyond: health from the neck up Introduce statistics from the https://humanetech.com/resources/app-ratings/
- https://www.youtube.com/watch?v=2Qa9YDgtcaM
- JULIET: Please link the plan button above, to this link, 1:08 to 2:25: https://www.youtube.com/watch?v=qzuM2XTnpSA “Timeless vignette in which the beautiful duet entitled "Sull'aria" from Mozart's "The Marriage of Figaro" is poignantly played for a sea of lonely men." Generic Evidence for Dopamine (music): Chanda, M. L., & Levitin, D. J. (2013, April 1). The neurochemistry of music. Trends in Cognitive Sciences. Elsevier. https://doi.org/10.1016/j.tics.2013.02.007 Ferreri, L., Mas-Herrero, E., Zatorre, R. J., Ripollés, P., Gomez-Andres, A., Alicart, H., … Rodriguez-Fornells, A. (2019). Dopamine modulates the reward experiences elicited by music. Proceedings of the National Academy of Sciences of the United States of America, 201811878. https://doi.org/10.1073/pnas.1811878116 Stark, E. A., Vuust, P., & Kringelbach, M. L. (2018). Music, dance, and other art forms: New insights into the links between hedonia (pleasure) and eudaimonia (well-being). Progress in brain research (Vol. 237, pp. 129–152). https://doi.org/10.1016/bs.pbr.2018.03.019 Zatorre, R. J. (2015). Musical pleasure and reward: Mechanisms and dysfunction. Annals of the New York Academy of Sciences, 1337(1), 202–211. https://doi.org/10.1111/nyas.12677 Salimpoor, V. N., Zald, D. H., Zatorre, R. J., Dagher, A., & McIntosh, A. R. (2015, February). Predictions and the brain: How musical sounds become rewarding. Trends in Cognitive Sciences. https://doi.org/10.1016/j.tics.2014.12.001 Zatorre, R. J., & Salimpoor, V. N. (2013). From perception to pleasure: Music and its neural substrates. Proceedings of the National Academy of Sciences, 110(Supplement_2), 10430–10437. https://doi.org/10.1073/pnas.1301228110 Salimpoor, V. N., Benovoy, M., Larcher, K., Dagher, A., & Zatorre, R. J. (2011). Anatomically distinct dopamine release during anticipation and experience of peak emotion to music. Nature Neuroscience (Vol. 14, pp. 257–264). https://doi.org/10.1038/nn.2726 Blood, A. J., & Zatorre, R. J. (2001). Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion. Proceedings of the National Academy of Sciences, 98(20), 11818–11823. https://doi.org/10.1073/pnas.191355898 Aalbers, S., Fusar-Poli, L., Freeman, R. E., Spreen, M., Ket, J. C., Vink, A. C., … Gold, C. (2017, November 16). Music therapy for depression. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD004517.pub3 Harrison, L., & Loui, P. (2014). Thrills, chills, frissons, and skin orgasms: toward an integrative model of transcendent psychophysiological experiences in music. Frontiers in Psychology, 5, 790. https://doi.org/10.3389/fpsyg.2014.00790 Moraes, M. M., Rabelo, P. C. R., Pinto, V. A., Pires, W., Wanner, S. P., Szawka, R. E., & Soares, D. D. (2018). Auditory stimulation by exposure to melodic music increases dopamine and serotonin activities in rat forebrain areas linked to reward and motor control. Neuroscience Letters, 673, 73–78. https://doi.org/10.1016/j.neulet.2018.02.058 Generic Evidence for EM (Nostalgia): Wildschut, T., Sedikides, C., Arndt, J., & Routledge, C. (2006). Nostalgia: Content, triggers, functions. Journal of Personality and Social Psychology, 91(5), 975-993. http://dx.doi.org/10.1037/0022-3514.91.5.975 Chen, H.-B., Yeh, S.-S., & Huan, T.-C. (2014). Nostalgic emotion, experiential value, brand image, and consumption intentions of customers of nostalgic-themed restaurants. Journal of Business Research, 67(3), 354–360. http://doi.org/https://doi.org/10.1016/j.jbusres.2013.01.003 Hwang, J., & Hyun, S. S. (2013). The impact of nostalgia triggers on emotional responses and revisit intentions in luxury restaurants: The moderating role of hiatus. International Journal of Hospitality Management, 33(1), 250–262. https://doi.org/10.1016/j.ijhm.2012.09.001 Oba, K., Noriuchi, M., Atomi, T., Moriguchi, Y., & Kikuchi, Y. (2016). Memory and reward systems coproduce ‘nostalgic’ experiences in the brain. Social Cognitive and Affective Neuroscience, 11(7), 1069. https://doi.org/10.1093/SCAN/NSV073 Cavanagh, S. R., Glode, R. J., & Opitz, P. C. (2015). Lost or fond? Effects of nostalgia on sad mood recovery vary by attachment insecurity. Frontiers in Psychology, 6(JUN), 773. https://doi.org/10.3389/fpsyg.2015.00773 Cheung, W.-Y., Wildschut, T., Sedikides, C., Hepper, E. G., Arndt, J., & Vingerhoets, A. J. J. M. (2013). Back to the Future. Personality and Social Psychology Bulletin, 39(11), 1484–1496. https://doi.org/10.1177/0146167213499187 Barrett, F. S., & Janata, P. (2016). Neural responses to nostalgia-evoking music modeled by elements of dynamic musical structure and individual differences in affective traits. Neuropsychologia, 91, 234–246. https://doi.org/10.1016/j.neuropsychologia.2016.08.012 Kuzmanovic, B., Rigoux, L., & Tittgemeyer, M. (2018). Influence of vmPFC on dmPFC Predicts Valence-Guided Belief Formation. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 38(37), 7996–8010. https://doi.org/10.1523/JNEUROSCI.0266-18.2018
- JULIET: Please link the plan button above, 1:50 - 3:06 https://www.youtube.com/watch?v=0PH0SV4j1Es Other clips for Endo: https://www.youtube.com/watch?v=l9m4cW2yxy0 (12M views) Generic Evidence for Endorphins (exercise): Balchin, R., Linde, J., Blackhurst, D., Rauch, H. L., & Schönbächler, G. (2016). Sweating away depression? the impact of intensive exercise on depression. Journal of Affective Disorders, 200, 218–221. https://doi.org/10.1016/j.jad.2016.04.030 Morres, I. D., Hatzigeorgiadis, A., Stathi, A., Comoutos, N., Arpin-Cribbie, C., Krommidas, C., & Theodorakis, Y. (2018). Aerobic exercise for adult patients with major depressive disorder in mental health services: A systematic review and meta-analysis. Depression and Anxiety. https://doi.org/10.1002/da.22842 Schwarz, L., & Kindermann, W. (1992). Changes in β-Endorphin Levels in Response to Aerobic and Anaerobic Exercise. Sports Medicine, 13(1), 25–36. https://doi.org/10.2165/00007256-199213010-00003 Schwarz, L., & Kindermann, W. (1990). Endorphin, adrenocorticotropic hormone, cortisol and catecholamines during aerobic and anaerobic exercise. European Journal of Applied Physiology and Occupational Physiology, 61(3–4), 165–171. https://doi.org/10.1007/BF00357593 Craft, L. L., & Perna, F. M. (2004). The Benefits of Exercise for the Clinically Depressed. The Primary Care Companion to The Journal of Clinical Psychiatry, 06(03), 104–111. https://doi.org/10.4088/PCC.v06n0301 Choi, K. W., Chen, C.-Y., Stein, M. B., Klimentidis, Y. C., Wang, M.-J., Koenen, K. C., & Smoller, J. W. (n.d.). Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults: A 2-Sample Mendelian Randomization Study. JAMA Psychiatry. https://doi.org/10.1001/JAMAPSYCHIATRY.2018.4175 Generic Evidence for Endorphins (thrill seeking): Hennig, J., Laschefski, U., & Opper, C. (1994). Biopsychological changes after bungee jumping: β-endorphin immunoreactivity as a mediator of euphoria? Neuropsychobiology, 29(1), 28–32. https://doi.org/10.1159/000119059
- JULIET: please link this content with the play button above https://www.youtube.com/watch?v=Zt9zcTnW4R4 Other clips for Oxy: https://www.youtube.com/watch?v=bo_efYhYU2A (star is born - 756M views) https://www.youtube.com/watch?v=y6INp3k-vFc (lion king - 5.7M views) Generic Evidence for Oxytocin (cute animal): Beetz, A., Uvnäs-Moberg, K., Julius, H., & Kotrschal, K. (2012). Psychosocial and Psychophysiological Effects of Human-Animal Interactions: The Possible Role of Oxytocin. Frontiers in Psychology, 3, 234. https://doi.org/10.3389/fpsyg.2012.00234 Borgi, M., & Cirulli, F. (2016). Pet Face: Mechanisms Underlying Human-Animal Relationships. Frontiers in Psychology, 7, 298. https://doi.org/10.3389/fpsyg.2016.00298 Borgi, M., Cogliati-Dezza, I., Brelsford, V., Meints, K., & Cirulli, F. (2014). Baby schema in human and animal faces induces cuteness perception and gaze allocation in children. Frontiers in Psychology, 5, 411. https://doi.org/10.3389/fpsyg.2014.00411 Golle, J., Lisibach, S., Mast, F. W., & Lobmaier, J. S. (2013). Sweet Puppies and Cute Babies: Perceptual Adaptation to Babyfacedness Transfers across Species. PLoS ONE, 8(3), e58248. https://doi.org/10.1371/journal.pone.0058248 IsHak, W. W., Kahloon, M., & Fakhry, H. (2011). Oxytocin role in enhancing well-being: A literature review. Journal of Affective Disorders, 130(1–2), 1–9. https://doi.org/10.1016/j.jad.2010.06.001 Nagasawa, M., Mitsui, S., En, S., Ohtani, N., Ohta, M., Sakuma, Y., … Kikusui, T. (2015). Oxytocin-gaze positive loop and the coevolution of human-dog bonds. Science, 348(6232), 333–336. https://doi.org/10.1126/science.1261022 Nagasawa, M., Kikusui, T., Onaka, T., & Ohta, M. (2009). Dog’s gaze at its owner increases owner’s urinary oxytocin during social interaction. Hormones and Behavior, 55(3), 434–441. https://doi.org/10.1016/j.yhbeh.2008.12.002 Nittono H, Fukushima M, Yano A, Moriya H (2012) The Power of Kawaii: Viewing Cute Images Promotes a Careful Behavior and Narrows Attentional Focus. PLoS ONE 7(9): e46362. https://doi.org/10.1371/journal.pone.0046362 Generic Evidence for Oxytocin (love): Dölen, G., Darvishzadeh, A., Huang, K. W., & Malenka, R. C. (2013). Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin. Nature, 501(7466), 179–184. https://doi.org/10.1038/nature12518 Ross, H. E., & Young, L. J. (2009). Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior. Frontiers in Neuroendocrinology, 30(4), 534–547. https://doi.org/10.1016/j.yfrne.2009.05.004 Uvnäs-Moberg, K. (1998). Oxytocin may mediate the benefits of positive social interaction and emotions. In Psychoneuroendocrinology (Vol. 23, pp. 819–835). Pergamon. https://doi.org/10.1016/S0306-4530(98)00056-0 Milek, A., Butler, E. A., Tackman, A. M., Kaplan, D. M., Raison, C. L., Sbarra, D. A., … Mehl, M. R. (2018). “Eavesdropping on Happiness” Revisited: A Pooled, Multisample Replication of the Association Between Life Satisfaction and Observed Daily Conversation Quantity and Quality. Psychological Science, 095679761877425. https://doi.org/10.1177/0956797618774252 Tamir, D. I., & Hughes, B. L. (2018). Social Rewards: From Basic Social Building Blocks to Complex Social Behavior. Perspectives on Psychological Science, 13(6), 700–717. https://doi.org/10.1177/1745691618776263
- JULIET: please link this content with the play button above https://www.youtube.com/watch?v=QZ6LfQko9WQ&list=RDQZ6LfQko9WQ&start_radio=1 Generic Evidence for Dopamine and Endorphins: Dopamine: Chanda, M. L., & Levitin, D. J. (2013, April 1). The neurochemistry of music. Trends in Cognitive Sciences. Elsevier. https://doi.org/10.1016/j.tics.2013.02.007 Ferreri, L., Mas-Herrero, E., Zatorre, R. J., Ripollés, P., Gomez-Andres, A., Alicart, H., … Rodriguez-Fornells, A. (2019). Dopamine modulates the reward experiences elicited by music. Proceedings of the National Academy of Sciences of the United States of America, 201811878. https://doi.org/10.1073/pnas.1811878116 Endo: Balchin, R., Linde, J., Blackhurst, D., Rauch, H. L., & Schönbächler, G. (2016). Sweating away depression? the impact of intensive exercise on depression. Journal of Affective Disorders, 200, 218–221. https://doi.org/10.1016/j.jad.2016.04.030 Morres, I. D., Hatzigeorgiadis, A., Stathi, A., Comoutos, N., Arpin-Cribbie, C., Krommidas, C., & Theodorakis, Y. (2018). Aerobic exercise for adult patients with major depressive disorder in mental health services: A systematic review and meta-analysis. Depression and Anxiety. https://doi.org/10.1002/da.22842
- https://www.youtube.com/watch?v=2Qa9YDgtcaM https://www.youtube.com/watch?v=iJv141b_O7s
- https://www.youtube.com/watch?v=2Qa9YDgtcaM https://www.youtube.com/watch?v=iJv141b_O7s
- https://docs.google.com/document/d/1y9pmNiKVpzW9OZ4Z1fIIXwhC2qcE5jevJnJOhhlqLh8/edit What is Calm doing that made it the first mental health unicorn? Mindfulness and neuroscience “Nike for the mind” Launched in 2012 Google Play Editor’s choice 2018 Help people meditate, relax and sleep better “Freemium” business model (basic facilities are free) App is simple and intuitive (good and calming user experience which guides people through the sign up process is an easy mannar) Sessions are short and accessible for busy individuals Profesional/expert meditation guides (tamara levitt) Partnerships (RED - to combat AIDs) Testimonials!! Sleep stories are a huge hit (with famous actors reciting scripts) Our smartphones are making it harder to sleep and think. Is the solution really yet another app? In 2018 and Calm raised $25 million on a $250 million valuation Calm needed something it could own, and that something was original content. "We're taking a leaf out of the Netflix strategy book," he says. ORIGINAL CONTENT App for mental fitness Dopamine-frazzled Deep relaxation 1. Sleep market size and forecast The U.S. sleep market was worth an estimated $28.6 billion in 2017. For 2018, the market grew by 3.3%. And in 2023 it is estimated to rise by another 4.7%. Global sleep industry estimated worth is approximately 76 billion per year. 2. The shifting sleep medications market The major prescription insomnia drugs market, led by Belsomra, Ambien, and Lunesta, has been declining in value. But are still said to total about $1.4 billion per year. However, the non-prescription or over the counter sleeping pills market, valued at $576 million, is growing faster. This is due to the general public becoming increasingly aware of the extreme negative side effects of prescribed sleep aids such as ambien - which is an extremely powerful sedative with adverse side effects such as amnesia 3. The size of the sleep labs market There are an estimated 4,700 U.S. sleep centers or labs which perform studies (polysomnograms) to diagnose sleep disorders. The typical lab has revenues of $920,000 and a bed count of about 7-8. Labs are located in hospitals, MD practices, universities, or are independent. This segment was worth $4.3 billion in 2017. There has been consolidation and closures due to reimbursement pressure from competing portable home testing devices approved by Medicare.
- Ed Sheeran’s “Shape of You” video has been watched more times since its release in 2017, than were human beings people alive on planet earth in 1980. And it’s still shy of the #1 title by 2B views. These are the 10 most viewed YouTube videos of all time Masha and the Bear – Recipe for disaster (4.18 billion) https://youtu.be/KYniUCGPGLs *** evidence that more and more young parents are using youtube to sooth and distract children. Scary to think the digital addiction is starting to early in life. Pinkfong – Baby Shark Dance (4.03 billion) https://youtu.be/XqZsoesa55w PSY – Gangnam Style (3.47 billion) https://youtu.be/9bZkp7q19f0 Justin Bieber – Sorry (3.22 billion) https://youtu.be/fRh_vgS2dFE Maroon 5 – Sugar (3.08 billion) https://youtu.be/09R8_2nJtjg Katy Perry – Roar (2.96 billion) https://youtu.be/CevxZvSJLk8
- Music Key Spotify Statistics: 217M monthly active Spotify users. 100 million of these are Spotify Premium subscribers. Spotify's can lay claim to 36% of the global streaming market. Average users listen to 41 unique artists per week. Average hours spent listening to Spotify per month stands at 25 hours.
- Music
- https://www.pexels.com/video/light-effects-animation-857050/ Or this other one, if the first doesn’t work well https://www.pexels.com/video/2235282/
- @eliza please add a summary of the CMS here–number of articles, examples of journals, etc. Moodrise app relies on database of more than 10,000 published peer-reviewed scientific articles - coming from high impact journals within the primary literature and world of academia. Our database has been programed to categorize content based on its ability to trigger the release of GABA, dopamine, oxytocin, endorphins, acetylcholine, or serotonin. The initial machine learning phase of this process has been successful which is immensely exciting as we move on to larger and greater content based collaborations with the likes of companies such as … xyz… Sony and Universal Studios.
- MPM Description 1) Videos of foods rich in Serotonin’s precursor molecule: Tryptophan (food such as chicken, eggs, cheese, fish, peanuts, pumpkin, sesame seeds, milk, and turkey) 2) Videos of the sun, activities in the sun, fun, leisure, pleasure, unwinding Social Interactions (reward) Some foods (chicken, eggs, cheese, fish, peanuts, pumpkin, sesame seeds, milk, and turkey) Some exercises Cognition, Memory and Learning Patience practices Sleep inducing content Social Interactions Self-transcendence
- MPM Description 1) Videos of calm or meditative references, meditation, breathing exercises, moments of tranquility, push notifications and reminders to check in 2) Videos of snow, nature, open air, etc. Yoga Meditation Music Attention, learning and memory Drink --> Ginseng or Matcha or Valerian root / valerian root extract or Oolong Viewing Images of Food
- MPM Description 1) Videos of sports, competitive athletics, football matches, etc 2) Videos of thrill seeking activities such as bungee jumping, tight rope walking, paragliding, extreme sporting events (the sports most commonly placed in this group are skateboarding, snowboarding, freestyle skiing, in-line roller-skating, street lugeing, and BMX and mountain biking) Exercise Grooming (social touch) --> see also Oxytocin Euphoria/Pleasure/thrill seeking Pain Relief/Laughter Music during exercise Wellbeing Sexual arousal
- MPM Description 1) Games, quizzes, eye catching materials, memory tasks, and all other cognitively engaging materials 2) Cogs fitting into place, sliding gears, piston pumping, wheels of a clock, Memory and learning (higher order thought processes) Skill Learning Neuroprotective Effects of Choline Regulation or mood Food: nuts for Cognitive Functioning Motivational videos and images Sleep inducing content
- MPM Description 1) Videos of people laughing, music, positive self appraisals 2) Images of high caloric foods: chocolate, sugar etc 3) Novel, beautiful, thought-provoking Pleasurable videos and images Expectation and pleasurable materials Pleasure and Happiness Music (pleasure/reward) Sad Music Music/Favorite song! (pleasure) Anticipation --> Music ASMR (reward/pleasure) Art and pleasure Aesthetics (artwork) Beauty (faces) Art and Music (together = pleasure) Changing Stimuli Food and Pleasure Anticipation of Food and Pleasure Chocolate and Pleasure Behaviour/Cognition/Learning/Experiences/Motivation Memory Novelty Attention & Focus --> Beverage Attention and Focus Meditation Positive Self Appraisals Curiosity Sensation-seeking Thrill seeking Creative Thinking (verbal and visual) Aversive stimuli - motivation, learning and cognition Beautiful Faces and Reward/Pleasure Humour - Pleasure/Reward Laughter **ALSO Serotonin Calories presented with food Gut/Microbiome Gestalt Theory (art and pleasure)
- MPM Description 1) Videos cute animals, puppies, kittens etc 2) Images people hugging, laughing, cuddling, smiling, interacting with each other etc Social Memory - facial recognition Social Interactions (reward) -- Serotonin also Trust, Connection Sex, Affection Pair-Bonding Cuteness (Images of...) Pets and Babies Own a dog Kawali (cuteness and baby schema) Singing (with others) Empathy Emotional Recognition Meditation Physical Contact (get a massage) Physical Contact → touch/hug/grooming Romantic Relationships Activities with Couples
- *This is a $750K paid partnership, bringing us to profitability in 2019.
- The plan of attack is specific and staged: Expand the current contract with US Air Force; sell across the armed services Sell AeBeZe products and services to radiologists and air traffic controllers Expand the program to target and include NCAA athletic programs Sell the product suite into US employers and insurance providers
- BUILD OUT The Product Development Timeline Please reorder the categories alphabetically: EARNED MEDIA, EVENTS, PAID MEDIA, PARTNERSHIPS, then SCIENCE + R&D