A small presentation for pharmacy students.

1. DIFFERENTIAL SCANNING
COLORIMETRY

2. PRINCIPLE

3. INSTRUMENTATION
• POWER COMPENSATED TYPE (PC)
• HEAT FLUX TYPE(HF)

4. POWER COMPENSATED TYPE (PC)

5. HEAT FLUX TYPE(HF)

6. FACTORS AFFECTING DSC CURVE
1.Instrumental Factors
• Furnace heating rate
• Recording or chart speed
• Furnace atmosphere
• Geometry of sample holder/locationof sensors
• Sensitivity of recording mechanism
• Composition of sample container

7. 2.Sample Characteristics
• Amount of sample
• Solubility of elvoved gases in sample
• Particle size
• Heat of reaction
• Sample packing
• Nature of sample
• Thermal conductivity

8. Advantages
• Small size upto 1 to 10mg
• Simple and rapid procedure of analysis,typically 15 to 30 min
per determination
• Ideal for comparison of sample purity for example in quality
control
• Does not require high absolute temperature accuracy
• Doesnot require calibration with known impurity
leavel,Cryoscopic constant is obtained simultaneously

9. APPLICATIONS

10. • To measure melting temp of crystalline solid.
• To measure the heat of fusion of a crystalline solid.
• To determine solubility of crystalline small molecule in polymer.
• To identify polymorphs as different polymorphs usually different
melting temp and heat of fusion.
• To determine percent purity.