This document discusses the embryology and development of the skull and spine, as well as common developmental anomalies that can occur. It begins with an overview of skull development, including the neurocranium and viscerocranium. It then discusses spine development and neurulation. Common skull anomalies discussed include anencephaly, craniosynostosis, and encephalocele. For the spine, anomalies discussed are spina bifida cystica, meningocele, myelomeningocele, and spina bifida occulta. The document emphasizes that early diagnosis and management of these anomalies is important for better prognosis, and that folic acid supplementation can help in prevention.