Depression is associated with imbalances in neurotransmitters like serotonin, norepinephrine, and dopamine, which antidepressants target. Cranial electrotherapy stimulation (CES) offers a drug-free alternative to restoring brain neurochemistry, showing a 70% symptom relief rate without withdrawal symptoms or negative side effects. CES can be safely used alongside existing medications, providing a potential solution for individuals with depression to achieve balance in their brain function.