The document provides information on Dengue Fever, including that it is caused by a mosquito-borne flavivirus transmitted by Aedes aegypti and Aedes albopictus mosquitoes. It has four serotypes that provide varying levels of immunity. Symptoms include fever, headache, rash and bleeding. Diagnosis involves antibody and viral testing. Severe dengue is classified as dengue hemorrhagic fever or dengue shock syndrome, characterized by bleeding, low platelets and plasma leakage. Monitoring of patients involves serial complete blood counts and hematocrit levels to detect signs of plasma leakage. Proper fluid management and monitoring for bleeding and organ dysfunction is important throughout the illness.
contains about the introduction , causative agents , transmission , clinical features , diagnosis , management and guidelines in Nepal , breaking the chain of transmission
contains about the introduction , causative agents , transmission , clinical features , diagnosis , management and guidelines in Nepal , breaking the chain of transmission
This webinar is organized by MyICID and Institute for Clinical Research (ICR), NIH, Ministry of Health in conjunction with Neglected Tropical Disease Day 2022. The purpose of this webinar is to refresh and update our knowledge on Dengue fever, which has been overshadowed by COVID-19 since the beginning of the pandemic.
Presenter: Dr Fazlina Binti Mohamed Yusoff, Family Medicine Specialist at Klinik Kesihatan (Health Clinic) Anika, Klang, Selangor, Malaysia.
#dengue #WorldNTDDay #BeatNTDs #BestScienceforAll
Pediatric dengue management - Dr. Arunkumar, MD(Paed)Arun Kumar
A presentation on clinical management of dengue fever and severe dengue in children.
By
Dr. Arunkumar. A, MD(Pediatrics)
consultant pediatrician,
KMCH Erode.
This webinar is organized by MyICID and Institute for Clinical Research (ICR), NIH, Ministry of Health in conjunction with Neglected Tropical Disease Day 2022. The purpose of this webinar is to refresh and update our knowledge on Dengue fever, which has been overshadowed by COVID-19 since the beginning of the pandemic.
Presenter: Dr Yasmin Mohamed Gani, Infectious Disease Physician at Hospital Sungai Buloh, Malaysia.
#dengue #WorldNTDDay #BeatNTDs #BestScienceforAll
Proper Case Presentation for Dengue Fever, Prevention, Treatment and everything else. Prepared by Dr Zain Khan, Doctor at Liaquat College of Medicine and Dentistry
The information regarding the dengue fever, Introduction, epidemiology, aetiology, symptoms, general management and prevention , along with one example of the journal club.
An acute fibrile illness syndrome caused by arboviruses that characterized by biphasic fever, myalgia, arthralgia, leukopenia, rash & lymphadenopathy.A.k.a dengue / breakbone fever
Only 1/3 of DHF patient develop shock and circulatory failure ( outpatient Tx is enough , bring back when there are alarming signs) .Early plasma, fluid & electrolyte replacement proved to have favourable outcome( maintain circulation). In DHF/DSS case, great care taken to reduce invasive procedures while managing shock
This webinar is organized by MyICID and Institute for Clinical Research (ICR), NIH, Ministry of Health in conjunction with Neglected Tropical Disease Day 2022. The purpose of this webinar is to refresh and update our knowledge on Dengue fever, which has been overshadowed by COVID-19 since the beginning of the pandemic.
Presenter: Dr Fazlina Binti Mohamed Yusoff, Family Medicine Specialist at Klinik Kesihatan (Health Clinic) Anika, Klang, Selangor, Malaysia.
#dengue #WorldNTDDay #BeatNTDs #BestScienceforAll
Pediatric dengue management - Dr. Arunkumar, MD(Paed)Arun Kumar
A presentation on clinical management of dengue fever and severe dengue in children.
By
Dr. Arunkumar. A, MD(Pediatrics)
consultant pediatrician,
KMCH Erode.
This webinar is organized by MyICID and Institute for Clinical Research (ICR), NIH, Ministry of Health in conjunction with Neglected Tropical Disease Day 2022. The purpose of this webinar is to refresh and update our knowledge on Dengue fever, which has been overshadowed by COVID-19 since the beginning of the pandemic.
Presenter: Dr Yasmin Mohamed Gani, Infectious Disease Physician at Hospital Sungai Buloh, Malaysia.
#dengue #WorldNTDDay #BeatNTDs #BestScienceforAll
Proper Case Presentation for Dengue Fever, Prevention, Treatment and everything else. Prepared by Dr Zain Khan, Doctor at Liaquat College of Medicine and Dentistry
The information regarding the dengue fever, Introduction, epidemiology, aetiology, symptoms, general management and prevention , along with one example of the journal club.
An acute fibrile illness syndrome caused by arboviruses that characterized by biphasic fever, myalgia, arthralgia, leukopenia, rash & lymphadenopathy.A.k.a dengue / breakbone fever
Only 1/3 of DHF patient develop shock and circulatory failure ( outpatient Tx is enough , bring back when there are alarming signs) .Early plasma, fluid & electrolyte replacement proved to have favourable outcome( maintain circulation). In DHF/DSS case, great care taken to reduce invasive procedures while managing shock
Dr. Sachin Verma is a young, diligent and dynamic physician. He did his graduation from IGMC Shimla and MD in Internal Medicine from GSVM Medical College Kanpur. Then he did his Fellowship in Intensive Care Medicine (FICM) from Apollo Hospital Delhi. He has done fellowship in infectious diseases by Infectious Disease Society of America (IDSA). He has also done FCCS course and is certified Advance Cardiac Life support (ACLS) and Basic Life Support (BLS) provider by American Heart Association. He has also done a course in Cardiology by American College of Cardiology and a course in Diabetology by International Diabetes Centre. He specializes in the management of Infections, Multiorgan Dysfunctions and Critically ill patients and has many publications and presentations in various national conferences under his belt. He is currently working in NABH Approved Ivy super-specialty Hospital Mohali as Consultant Intensivists and Physician.
Dengue is a febrile illness caused by a flavivirus transmitted by Aedes aegypti or Aedes albopictus mosquitoes while taking a blood meal. There are four dengue virus (DENV) types (DENV-1, DENV-2, DENV-3, and DENV-4), all of which are capable of inducing severe disease (dengue hemorrhagic fever [DHF]/dengue shock syndrome [DSS]). Dengue is endemic in more than 125 countries in tropical and subtropical regions and causes an estimated 390 million infections annually worldwide, of which 96 million are clinically apparent
In dengue-endemic regions, suspected, probable, and confirmed cases of dengue infection should be reported to the relevant authorities as soon as possible, so that appropriate measures can be instituted to prevent dengue transmission
A mosquito-borne viral disease occurring in tropical and subtropical areas.
Those who become infected with the virus a second time are at a significantly greater risk of developing severe disease.
Symptoms include high fever, headache, rash and muscle and joint pain. In severe cases there is serious bleeding and shock, which can be life threatening.
Treatment includes fluids and pain relievers. Severe cases require hospital care.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
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2 Case Reports of Gastric Ultrasound
2. Virology
Dengue Virus Mosquito-borne flavivirus
Transmitted by Aedes aegypti and Aedes albopictus.
Serotypes -> DEN-1, 2, 3 and 4.
Each episode of infection induces a life-long protective
immunity to the homologous serotype but only partial and
transient protection against subsequent infectionof other
three serotypes
3. Course
incubation period is 4-7 days (range 3-14)
It may be asymptomatic or may result in a spectrum of
illness ranging from undifferentiated mild febrile illness to
severe disease, with or without plasma leakage and organ
impairment.
Symptomatic dengue infection is a systemic and dynamic
disease with clinical, haematological and serological
profiles changing from day to day
4.
5. WHO (1997) CASE DEFINITION FOR DENGUE FEVER
Probable – an acute febrile illness with two or more of the following manifestations:
headache
retro-orbital pain
myalgia
arthralgia
rash
haemorrhagic manifestations
leukopenia
AND
supportive serology (a reciprocal haemagglutination-inhibition antibody titre ≥ 1280, a
comparable IgG enzyme-linked immunosorbent assay (ELISA) titre or a positive IgM antibody test
on a late acute or convalescent-phase serum specimen)
OR
occurrence at the same location and time as other confirmed cases of dengue fever
Confirmed – a case confirmed by laboratory criteria (see below).
Reportable – any probable or confirmed case should be reported.
6. Cont’ - CASE DEFINITION FOR DENGUE FEVER
Laboratory criteria for confirmation of dengue fever are
Isolation of the dengue virus from serum or autopsy samples: or
Demonstration of a fourfold or greater change in reciprocal IgG or
IgM antibody titres to one or more dengue virus antigens in paired
serum samples; or
Demonstration of dengue virus antigen in autopsy tissue, serum or
cerebrospinal fluid samples by immunohistochemistry,
immunofluorescence or ELISA;
OR
Detection of dengue virus genomic sequences in autopsy tissue serum
or cerebrospinal fluid samples by polymerase chain reaction (PCR)
7. WHO (1997) CASE DEFINITION FOR DENGUE
HAEMORRHAGIC FEVER
following must ALL be present :
Fever, or history of acute fever, lasting 2–7 days, occasionally biphasic.
Haemorrhagic tendencies, evidenced by at least one of the following :
a positive tourniquet test
petechiae, ecchymoses or purpura
bleeding from the mucosa, gastrointestinal tract, injection sites or other locations
haematemesis or melaena.
Thrombocytopenia (100,000 cells per mm3 or less).
Evidence of plasma leakage due to increased vascular permeability, manifested by
at least one of the following:
a rise in the HCT equal to or greater than 20% above average for age, sex and
population;
a drop in the HCT following volume-replacement treatment equal to or greater than
20% or baseline;
signs of plasma leakage such as pleural effusion, ascites and hypoproteinaemia.
8. WHO (1999) CASE DEFINITION FOR DENGUE
SHOCK SYNDROME
All of the above four criteria for DHF must be present, plus
evidence of circulatory failure manifested by :
Rapid and weak pulse, and
Narrow pulse pressure [<20mmHg (2.7 kPa)]
OR manifested by :
Hypotension for age, and
Cold, clammy skin and restlessness.
9. Another classification of Dengue Haemorrhagic
Syndrome by Grades
NON-SHOCK PATIENTS
Grade l : Fever accompanied by non-specific constitutional symptoms; the
only haemorrhagic manifestation is a positive tourniquet test and / or easy
bruising.
Grade ll : Spontaneous bleeding, in addition to the manifestations of Grade
l patients, usually in the form of skin or other haemorrhages.
DENGUE SHOCK SYNDROME
*Grade lll : Circulatory Failure manifested by a rapid, weak pulse and
narrowing of pulse pressure or hypotension with the presence of cold,
clammy skin and restlessness.
*Grade lV : Profound shock with undetectable blood pressure or pulse.
10.
11.
12. TOURNIQUET TEST
DHF grade 1, a positive tourniquet test serves as the only indicator
ofhaemorrhagic tendency.
The sensitivity of the : 0% to 57%, depending on the phase of illness
and how often the test was repeated, if negative.
5-21% of patients with dengue like illness had positive tourniquet test
but subsequently have negative dengue serology
A recent study demonstrated that there was 95.3% positive
predictive value if fever, positive tourniquet test, leucopenia/
thrombocytopaenia / haemoconcentration were used as screening
criteria
The tourniquet test may be useful as an additional tool when the
diagnosisis in doubt, especially when the platelet count is still
relatively normal.
13.
14. Diagnostic Lab Test
Dengue IgM test - is significantly higher in primary infections, compared
to secondary infections. Once the IgM is detectable, it rises quickly and
peaks at about 2 weeks after the onset of symptoms, and it wanes to
undetectable levels by 60 days. However in some patients, it may
persist for more than 90 days. positive result has to be intepreted and
correlated cautiously with the clinical picture
Indirect IgG ELISA test - primary and secondary dengue infection,
dengue IgG was detected in 100% of patients after day 7 of onset of
fever. Therefore dengue IgG is recommended if dengue IgM is still
negative after day 7 with the negative IgG in the initial test sample.
15. Key points in Interpretation
In order to establish serological confirmation of dengue illness a seroconversion of dengue IgM
needs to be demonstrated. Therefore a dengue IgM should be taken as soon as the disease is
suspected.
Dengue IgM is usually positive after day 5-7 of illness. Therefore a negative IgM taken before day
5-7 of illness does not exclude dengue infection.
If dengue IgM is negative before day 7, a repeat sample must be taken in recovery phase.
If dengue IgM is still negative after day 7 with negative IgG tested at less then 7 days, dengue IgG
is recommended for diagnostic confirmation.
False positive dengue serology - Serological tests for dengue have been shown to cross-react with:
other flavivirus – Japanese Encephalitis
non-flavivirus – malaria, leptospirosis, toxoplasmosis, syphilis
connective tissue diseases – rheumatoid arthritis
16. Other diagnostic test
VIRUS ISOLATION – takes 2 week to complete & expensive
POLYMERASE CHAIN REACTION (PCR) - ability to determine dengue
serotypes, but limited centres with facilities, expensive, special storage
temperatures and short transportation, time between collection and
extraction
NON-STRUCTURAL PROTEIN-1 (NS1 Antigen) - a hallmark of flavivirus
infecting mammalian cells and can be found in dengue infection as well as
in yellow fever and West Nile virus infection. Present high concentrations
in the sera of dengue infected patients during the early phase of the
disease. not useful in the convalescence phase. However,this test is still
undergoing evaluation.
24. PATIENT TRIAGING AT EMERGENCY & TRAUMA / OUTPATIENT
DEPARTMENT
The purpose of triaging patients is to determine whether they require
urgent attention. This is to avoid critically ill patients being missed
upon arrival.
27. Referral From hospitals without specialist to
hospitals with specialists
Early consultation with the nearest physician should
be initiated for ALL DHF or DF with organ
dysfunction/ bleeding.
28. Issues of Monitoring According to
Different Phases Of Dengue Illness
Febrile
- Differentiation of dengue illness from other febrile illnesses.
- Not possible to differentiate DF from DHF.
Critical
- Plasma leakage occurs as patient progresses to late febrile phase or as temperature begins
todefervescence (T < 38.0 °C).
- Clinical deterioration occurs during this phase due to plasma leakage.
- Plasma leakage results in haemoconcentration and hypovolemia/ shock.
- Excessive plasma leakage due, in part, to intravenous fluid therapy may cause respiratory
distress.
- Bleeding can be precipitated by prolonged shock and shock can be perpetuated by bleeding.
- May mimic acute abdomen of other causes.
- May be confused with septic shock or other forms of shock.
29. Reabsorption
- Cessation of plasma leakage.
- Reabsorption of fluid from extravascular compartment.
- Haemodilution occurs following fluid reabsorption.
- Hypervolaemia and pulmonary oedema if intravenous fluid
therapy is continued.
30.
31.
32.
33. Lab work monitoring throughout the course
Full Blood Count (FBC)
1. White cell count (WCC) : In early febrile phase WCC is usually normal but will
decrease rapidly as the disease progresses. This trend of leucopenia should raise the
suspicion of possible dengue infection.
2. Haematocrit (HCT) : A rising HCT is a marker of plasma leakage in dengue infection
and helps to differentiate between DF and DHF but it can be masked in patients with
concurrent significant bleeding and in those who receive early fluid replacement. Setting
the patient’s baseline HCT in the early febrile phase of disease will be very useful in the
recognition of a rising HCT level.
3. Thrombocytopaenia : In the early febrile phase, platelet count is usually within normal
range but it will decrease rapidly as the disease progresses to the late febrile phase or at
defervescence. it may continue to remain low for the first few days of recovery. There is
a significant negative correlation between disease severity and platelet count
Liver Function Test
Elevated liver enzymes is common and is characterised by greater elevation of the AST as
compared to the ALT.. The frequency and degree of elevation of the liver enzymes are
higher with DHF compared to DF.
34. Key points in Monitoring
Leucopaenia followed by progressive thrombocytopaenia is suggestive of
dengue infection.
A rising HCT accompanying progressive thrombocytopaenia is suggestive
of DHF.
There is no local data available on the normal range of HCT in adults. In
the absence of a baseline HCT level, a HCT value of >40% in female
adults and >46% in male adults should raise the suspicion of plasma
leakage.
Recommendation
The baseline HCT and WCC should be established as early aspossible in
all patients with suspected dengue.
Serial FBC and HCT must be monitored as the disease progresses.
35.
36.
37. DISCHARGE CRITERIA
• Afebrile for 48 hours
• Improved general condition
• Improved appetite
• Stable haematocrit
• Rising platelet count
• No dyspnoea or respiratory distress from pleural effusion or
ascites
• Resolved bleeding episodes
• Resolution/recovery of organ dysfunction
38. DENGUE IN PREGNANCY - All pregnant women with
suspected dengue infection must be admitted.
The following physiological changes in pregnancy may make the
diagnosis and assessment of plasma leakage challenging :
• Elevation of HCT in dengue is masked by haemodilution due to
increase in plasma volume especially in the 2nd and 3rd trimester.
Serial HCT measurement is crucial for disease monitoring in
pregnancy.
• The detection of third space fluid accumulation is difficult due
to the presence of gravid uterus.
• Baseline blood pressure is often lower and pulse pressure wider
• Baseline heart rate may be higher.
39. Management of infected pregnant patients close to delivery :
• Risk of bleeding is at its highest during the period of plasma
leakage (critical phase).
• If possible, avoid Lower Segment Caesarean Section (LSCS) or
induction of labour during critical phase (plasma leakage)
• Procedures/manoeuvres that may provoke or augment labour
should be avoided during this critical phase.
Care for the mother should be provided in a multidisciplinary way in an
area of the hospital where there are trained personnel available to
handle labour and its complications.
The baby should be observed for vertical transmission of dengue after
delivery.