Dementia was first described in 1894 by Dr. Alois Alzheimer, who observed changes in the brain caused by vascular disease. Dementia is defined as an acquired impairment of intellect, memory and personality without impaired consciousness. It is caused by damage or loss of nerve cells and their connections in the brain. The four main causes of dementia are Alzheimer's disease, frontotemporal dementia, dementia with Lewy bodies, and vascular dementia. Alzheimer's disease mainly affects the hippocampus and controls aspects of memory and navigation. Brain scans of Alzheimer's patients show shrinking grey matter and more problems as cells die over time.