The DAFNE project aims to establish a decision-analytic framework for integrated planning of water, energy, and food resources in transboundary contexts in fast-growing countries. The framework will develop understanding of the water-energy-food nexus, generate alternative management solutions, and foster equitable resource use without environmental harm. Case studies include the Zambezi River Basin shared by 8 countries and the transboundary Omo-Turkana basin of Ethiopia and Kenya. The project involves stakeholders and uses modeling and scenarios to assess management alternatives and pathways.