SIM4NEXUS is a 4-year, €7.9M EU Horizon 2020 project that aims to improve decision-making around the water-land-food-energy-climate nexus through an integrated modeling approach. The project involves 25 partners across 15 European countries and will develop nexus models by combining existing thematic models from different domains using complexity science methods. These models will be applied in 10 case studies at regional to global scales to assess policy initiatives and trade-offs. The project will also create a serious game to educate stakeholders and decision-makers about sustainable resource management.