François Meurens is a research scientist from Belgium with expertise in veterinary sciences and immunology. He received his doctorate in veterinary sciences from the University of Liège in Belgium. His research focuses on porcine immunology, virology, parasitology, and vaccine development using pig models. He has worked at the University of Saskatchewan and the National Institute of Agronomic Research in France.
El 12 de mayo de 2017 celebramos en la Fundación Ramó Areces una jornada con IS Global y Unitaid sobre enfermedades transmitidas por vectores, como la malaria, entre otras.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
El 12 de mayo de 2017 celebramos en la Fundación Ramó Areces una jornada con IS Global y Unitaid sobre enfermedades transmitidas por vectores, como la malaria, entre otras.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
NVBDCP.pptx Nation vector borne disease control program
Curriculum vitae meurens_f_04_2014
1. CURRICULUM VITAE
IDENTITY: MEURENS François
Born in Louvain, Belgium on May 22nd
, 1976
ADDRESS: App. 214, 325-5th
Avenue North
Saskatoon, Saskatchewan S7K 2P7
Canada
Phone: +001 306 9668874
E-mail: fmeurens@yahoo.fr
francois.meurens@usask.ca
Profil on: http://www.linkedin.com
EDUCATION: Doctor in Veterinary Medicine, Université Catholique de
Louvain, UCL (first 3 years) and Université de Liège, ULg (last 3
years), Belgium, 2000 (highest grade, rank: 1/168).
Master of Veterinary Sciences (DEA), Université de Liège,
ULg, Belgium, 2001 (highest grade). Master’s thesis: “Study on
molecular recombination in bovine herpesvirus 1”.
PhD in Veterinary Sciences (Virology), Université de Liège,
ULg, Belgium, 10 September 2004 (highest grade). “Influence
of superinfection delay and genetic relatedness on bovine
herpesvirus 1 recombination”.
Postdoctoral fellow, University of Saskatchewan, Vaccine and
Infectious Disease organization (VIDO, Saskatoon, Canada),
4/01/2005 to 01/10/2006. Training period as INRA scientist in
the same place from October 2006 to March 2007.
Immunology training courses, « 18ème
cours annuel
d’immunologie de la société française d’immunologie » (30h),
Carry le Rouet, France, March 12-15th
, 2008.
Curriculum Vitae, François Meurens, 1
2. Authorization to lead research (HDR), Université François
Rabelais, Tours, France. September 2008 (highest grade). A
degree required in France to supervise graduate students.
Immunology training courses, « 19ème
cours annuel
d’immunologie de la société française d’immunologie » (30h),
La Grande Motte, France, April 1st
to 4th
, 2009.
Immunology training courses, « 20ème
cours annuel
d’immunologie de la société française d’immunologie » (30h),
La Grande Motte, France, March 29th
-April 1st
, 2010.
PROFESSIONAL CAREER AND MAJOR ACHIEVEMENTS:
♦ Vaccine and Infectious Disease Organization (VIDO-InterVac, 05/2012-now
Saskatoon, Canada), Research Scientist III
(Porcine immunology and infectious diseases)
♦ Veterinary Microbiology Department (University of Saskatchewan, 06/2012-06/2017
Saskatoon, Canada), Adjunct Professor.
♦ National Institute of Agronomy Research (INRA), Scientist CR1, 10/2006-05/2012
UR1282, Team leader.
“Relations Hôte/Pathogène dans le modèle Porcin” then, « Virologie
et Immunologie des muqueuses ». Ranked A (AERES 2012).
Teaching (Master 2, ICMV, Animal experimentation and Licence3 MAI)
at Université François Rabelais, Tours, France (approximately 20h/year).
♦ Postdoctoral fellow at Vaccine and Infectious Disease Organization 01/2005-10/2006
(VIDO), University of Saskatchewan, Saskatoon, Canada.
♦ Assistant at the service of virology and epidemiology 10/2004-12/2004
University of Liège (Faculty of Veterinary Medicine, Belgium).
♦ FNRS research fellow (National Research Funds of Belgium) 10/2000-10/2004
Study of genetic recombination in Alphaherpesvirinae family.
♦ Private veterinary practice, companion animals. 07/2000
Practice in collaboration with Dr M. Reuliaux in Nil St-Vincent.
Belgium
♦ Student jobs Summer 1994,
95, 96, 97, 99.
-French Community Department of “Enseignement Supérieur et Recherche
Scientifique”.
-Université de Liège (Physiology of Reproduction, Professeur J-F Beckers Faculty of
Veterinary Medicine). Belgium.
RESEARCH INTERESTS AND COLLABORATIONS:
Curriculum Vitae, François Meurens, 2
3. Porcine immunology (innate immune response, host/pathogen interactions,
development of the neonatal immune system, lymphocyte trafficking), Virology (bovine
herpesviruses, porcine respiratory and reproductive syndrome virus, and influenza),
Parasitology (Entamoeba histolytica), Bacteriology (Chlamydia suis and trachomatis,
Salmonella enterica, Escherischia coli), Probiotics (Saccharomyces cerevisae), Vaccinology
(vaccine development and safety assessment), Pig model development, Veterinary
Sciences, and Animal experimentation.
Previous leader of the team “Host/Pathogen Interactions in Pig" in Tours (INRA,
France) until my moving to VIDO (Canada; Principal Investigator and Adjunct Professor in
Veterinary Microbiology). My team studies host/pathogen interactions in the pig model and
aims at developing new porcine models to study human pathogens (C. trachomatis) and to
test new candidate vaccines.
Consulting activity for Danone Research (France).
Several collaborations:
-Porcine infectious diseases (Pr. Carl Gagnon), Université de Montréal, Québec, Canada.
Collaboration on PRRSV and porcine trachea epithelial cells.
-Porcine Immunology (Pr. Armin Saalmüller), Institute of Immunology, Department of
Pathobiology, University of Veterinary Medicine Vienna, Austria. Collaboration on T cells in
pigs.
-Biologie cellulaire du Parasitisme (Dr. Nancy Guillén), INSERM U786, Pasteur Institute
(Paris, France): This collaboration is about Entamoeba histolytica and the establishment of a
porcine model of this human parasite.
-Graft and dendritic cells team (Pr. Yvon Lebranchu) at Université François Rabelais (Tours,
France): This collaboration is about porcine dendritic cells.
-“Laboratoire des bactéries lactiques et immunité des muqueuses” (Dr. Bruno Pot) at Pasteur Institute
(Lille, France): The goal of this collaboration is the development of probiotic vector (Lactoccocus and
Lactobacillus) able to secrete cytokines or chemokines.
-Institute of Virology and Immunoprophylaxis (Pr. Artur Summerfield) (Mittelhäusern,
Switzerland): We have frequent collaborations with this Institute (monoclonal antibodies
workshop).
-Veterinary University of Hannover, Tierärztliche Hochschule Hannover, TiHo (Pr. Georg
Herrler) (Hanovre, Germany). We have collaborations about porcine flu and new system to
study interactions between the virus and the host.
-Agence nationale chargée de la sécurité sanitaire de l’alimentation, de l’environnement et
du travail, Anses (Dr. Gaëlle Simon) (Ploufragan, France). We have collaborations about
porcine flu.
SCIENTIFIC WORKS:
ARTICLES AND REVIEWS
Curriculum Vitae, François Meurens, 3
4. The “ranking” of the articles comes from “Journal of Citation report, 2012”. See publication
list.
KEY PERSONAL FEATURES:
- Able to work independently or in teams. I supervised studies thesis of numerous
graduate students.
- Ability to analyse and resolve complex situations.
- Open and positive minded, dynamic and entrepreneurial. Able to build up excellent
and reliable relationship with people.
- Adaptable to different types of responsibilities and styles. At ease in multicultural
environments.
PROFESSIONAL BACKGROUND:
TECHNICAL: Able to use different techniques like cell, virus and protozoa
(Entamoeba histolytica) cultures, tissue explant culture, RT-qPCR
(SYBR green and Taqman), RACE PCR, electrophoresis (conventional
and pulsed field), Southern and Western blot, cloning, simple and
double immunofluorescence staining, animal experimentation (levels 2
and 3 facilities), clinical monitoring.
SCIENTIFIC: Originally specialized in virology and the research on herpesviruses
such as bovine herpesvirus 1. I wrote a number of publications in
scientific journals and presentations at congress (details provided
above). Then, I started to work on the pig model (pig immunology and
development of pig models for the study of various human diseases). I
am still currently involved in the pig research.
LANGUAGE CAPABILITY: -French: Mother language.
-English: Fluent.
-Spanish: Good knowledge.
AWARDS AND GRANTS:
-Coordinator for a project funded by the Saskatchewan Health Research Foundation (SHRF,
establishment grant), “Establishment of a porcine model to study human genital Gonorrhoea
and Chlamydia”, 120,000 Canadian dollars (2013-2016).
-Coordinator for a project funded by the “Natural Sciences and Engineering Research
Council of Canada” (NSERC, discovery grant), “Les protéines Suppressor of Cytokine
Signalling (SOCS) et leur implication dans la régulation de la réponse innée aux infections
virales porcines”, 30,000 Canadian dollars (2013-2015).
-Co-PI in a grant from European NADI program, coordinator: Georg Herrler, “Innate immune
responses after infection with swine influenza virus H1N1 in naïve SPF pigs or SPF pigs pre-
infected with Mycoplasma hyopneumoniae”, 20,000 euros (2012-2013).
Curriculum Vitae, François Meurens, 4
5. -Co-PI in a Region Centre Grant on porcine cystic fibrosis model, coordinator: Bertrand
Schwartz, “Modèle d'Infections Respiratoires par Pseudomonas aeruginosa chez le porc”,
100,000 euros (2012-2014).
-Co-PI in an ANR program Sus_Flora, coordinator: Claire Rogel-Gaillard, “Gut microbiota
and homeostasis of immune system in swine: a joint genetic and genomic study”, 769,130
euros/3 years (2011-2014).
-Co-PI in a grant from Lesaffre SA to study the immuno-modulatory effect of Saccharomyces
cerevisae in the porcine model of enterotoxigenic colibacillosis, coordinator: Henri Salmon,
168,000 euros/3 years (2008-2011).
-PTR (transversal program) Pasteur (Paris)/INRA, coordinators of the program: François
Meurens and Fabienne Girard-Misguich, “Development of an immunopathologic swine model
for intestinal human amoebiasis”, 118,000 euros/2 years (2008-2010).
-Travel Grant from the French Embassy in Canada 2007 (2000 euros).
-Rotary District 1630 Grant 2005 (9000 euros) for international studies.
-First prize 2000 of the veterinary journal: “Annales de Médecine Vétérinaire” for studies
thesis: detection of recombinant viruses after co-infection of calves with two bovine
herpesvirus 1 strains.
OTHER ACTIVITIES AND MEMBERSHIPS:
• Member of French Veterinary Order (Région Centre) 2009-2012: Number 23649.
• Member of the Belgian Veterinary Order August 2000-December 2004: Number 3744.
• Member of the “Société Française d’Immunologie” 2008-2012: Number 3518.
• Member of the Editorial Board of the International Journal: Veterinary Immunology and
Immunopathology since January 2010, World Journal of Immunology since August 2012, and
Frontiers in Veterinary Medicine since March 2014.
• Member of the Administrative Board of AFMVP (“Association Française de Médecine
Vétérinaire Porcine”). since December 2010.
• Member of the Ethics Committee Val de Loire (2010-2012) (Veterinarian group).
• Member of the Ethics Committee University of Saskatchewan (AREB) (since June 2012).
PERSONAL INTERESTS:
-History, world news, swimming, classical and rock music.
REFERENCES:
-Pr. Etienne Thiry (Université de Liège, Belgique)
Etienne.Thiry@ulg.ac.be
-Pr. Georg Herrler (Tierärztliche Hochschule Hannover, Germany)
Georg.Herrler@tiho-hannover.de
-Dr. Nancy Guillén (Institut Pasteur, France)
nancy.guillen@pasteur.fr
Curriculum Vitae, François Meurens, 5
6. -Dr. Sasha Gogev (Pfizer) (Louvain-La-Neuve, Belgique)
sacha.gogev@pfizer.com
Last update : 26/04/2014
Curriculum Vitae, François Meurens, 6
7. -Dr. Sasha Gogev (Pfizer) (Louvain-La-Neuve, Belgique)
sacha.gogev@pfizer.com
Last update : 26/04/2014
Curriculum Vitae, François Meurens, 6