1. UMP WELCOMES
Professor MARIANO ANDERLE Ms. CARLOTTA COLLI
Scientific Attache Consul General of Italy
Italian Embassy - Vietnam Ho chi Minh City, Vietnam
University of Medicine & Pharmacy (UMP)
Ho Chi Minh City, VIETNAM
4. Prof. Tran, Diep Tuan
President, UMP
As a leading institute in medical education of Vietnam, the promotion of scientific
research activities has always been an active and pivotal part of our mission.
UMP is now taking the new challenge in developing modern biomedical research
to align our scientific programs with the international medical community, and
importantly, to harness the advancements of biological sciences for medical
services, via translational research, for unmet medical illnesses of the Vietnamese
patients.
5. Members of the Biomedicine Program at UMP
5
Thuy Thanh Thi Do, MD PhD - Vice Director
Bao Chi Bui, PhD - Faculty
Vu Anh Hoang, MD PhD - Vice Director
Son Tan Vo, MD PhD - Director
Thai Duc Nguyen, PhD - Advisor/International Relation
Minh Duc Do, MD PhD - Faculty
Tuan Thanh Huynh, MD PhD - Faculty
7. Philosophy & Direction
The TRANSLATIONAL MEDICINE of UMP aspires
to create:
- Biomedical doctors and life science researchers
of Vietnam to innovate the basic and clinical
research in and their applications on health care
- A rich biotech ecosystem, besides conventional
trainings, at all stages and agendas of the school
in response to the demand for innovation
- A necessary responsible social agenda aiming
for needs-driven innovation serving the general
population of Vietnam
8. UNIVERSITY MEDICAL CENTER
UNIVERSITY MEDICAL CENTER
Address: 215 Hong Bang St., Dist.5,
Ho Chi Minh City, Viet Nam
Tel: (84-8) 3855 4269
Email: bvdh@umc.edu.vn
Website: www.bvdaihoc.com.vn
University of Medicine & Pharmacy (UMP)
Prof. Nguyen, D. Hoi
Founder & President
UMP Hospital
(~ 5,000 outpatients/daily - 15 Departments)
9. UNIVERSITY MEDICAL CENTERUNIVERSITY MEDICAL CENTER
BRANCHES
Branch No1
270 beds
Branch No.2 70
beds
Branch No.3 30
beds
Branch No.4
190 beds
Branch No.5
200 beds
TOTAL
760 BEDS
10. UNIVERSITY MEDICAL CENTERUNIVERSITY MEDICAL CENTER
HUMAN RESOURSE
Physician 725
Pharmacist 92
Registered nurse 436
Midwife 175
Technician 200
Others 824
TOTAL 2,353
11.
12. STEPS FOR TRANSLATIONAL RESEARCH & MEDICAL
PRACTICE AT UMP
1) Create Biomedical Program/UMP as an academic home
for Translational Research associates with clinical
studies at hospitals of HCM City and other parts of
Vietnam.
2) Identify innovative and beneficial research projects and
facilitate bench-to-bedside translation (e.g. diagnostics,
therapies).
3) Facilitate clinical investigators at hospitals to benefit
from Translational Research at UMP and collaborators
(e.g. efficient clinical studies).
4) Translate health benefits to the public via engagement
of the hospitals and its affiliates.
BioMed Clinical investigators Hospitals Public
18. Teaching: Biomedicine
Collaboration:
- Partnership with leading
institutes of VN & international
Conference:
- Importing the world knowledge
- Promoting progresses of Vietnam
Advisory:
- Connecting to the international
community
- Assisting development in VN
R&D:
- Building biotech platforms for
innovation toward advancement
Industry Relation:
- Building Biotech group
for commercialization
Building the Biomedical Program
at UMP - Ho Chi Minh City
TRANSLATIONAL
MEDICINE
19.
20.
21. SIGNIFICANCE
(UMP Biomedical Program)
- Training grassroots of biomedical scientists/physicians
to promote biomedicine for Vietnam health care
- Improving efficacy of health care via implementation
of biotechnologies in the R&D on unmet medical issues
affecting the Vietnamese population
- Promoting high value biologics via developing bio-
pharmaceutical sectors of Vietnam
- Achieving the ultimate goal of making UMP a modern
biomedical research center of Vietnam
25. + cytokines
DC CANCER
THERAPY
Viet Quoc Pham, Sinh Truong Nguyen, Phuc Van Pham: Production of functional dendritic cells from mouse bone marrow. Biomedical Research and Therapy.
09/2014; 1(4).
Pham Van Phuc, Chi Jee Hou, Nguyen Thi Minh Nguyet, Duong Thanh Thuy, Le Van Dong, Truong Dinh Kiet, Phan Kim Ngoc: Effects of breast cancer
stem cell extract primed dendritic cell transplantation on breast cancer tumor murine models. Annual Review & Research in Biology. 01/2011; 1:1-13.
CANCER VACCINE THERAPIES
26.
27. 27
Khanh Hong-Thien Bui, Triet Dinh Duong, Nhan Thanh Nguyen, Thanh Duc Nguyen, Vien Tuong Le, Viet Thanh Mai, Nhan Lu-Chinh Phan, Dung
Minh Le, Ngoc Kim Phan, Phuc Van Pham: Symptomatic knee osteoarthritis treatment using autologous adipose derived stem cells and platelet-rich
plasma: a clinical study. Biomedical Research and Therapy. 02/2014; 1(1):2-8.
Phuc Van Pham, Ngoc Bich Vu, Thuy Thanh Duong, Tam Thanh Nguyen, Nhung Hai Truong, Nhan Lu Chinh Phan, Tue Gia Vuong, Viet
Quoc Pham, Hoang Minh Nguyen, Kha The Nguyen, Nhung Thi Nguyen, Khue Gia Nguyen, Lam Tan Khat, Dong Van Le, Kiet Dinh
Truong, Ngoc Kim Phan: Suppression of human breast tumors in NOD/SCID mice by CD44 shRNA gene therapy combined with doxorubicin
treatment.. OncoTargets and Therapy 01/2012; 5:77-84.
STEM CELL THERAPIES
28. Procedures for mAb Cloning
Therapeutic mAb
A
B
C
Inoculation
Hybridoma
Cloning L-H
D Humanization
MONOCLONAL ANTIBOBY THERAPIES
29. 1st
2nd
3rd
HBV Vaccine: The 3 rd Generation
HBV Vaccines & VLP (virus like particle) Technologies
1 st generation: HBV surface antigens from the serum
of hepatitis patients, Australia; approved in 1980.
2 nd generation: Recombinant VLP vaccine from yeast
using S antigen (i.e. HBsAg) by Chiron, USA;
approved in 1986 .
3 rd generation: Recombinant VLP vaccine from CHO
using multi complex antigens of S, PreS1 and PreS2
(Sci-B-Vac by SciGen), Israel; approved in 2013
NOVEL VACCINE
30. infectious
not
infectious
VLP Vaccines vs. Traditional Vaccines
1 - Very safe due to lack of the viral nuclear DNA/RNA genes,
and eggs are not used & could be applied universally for other viruses.
2 - VLP vaccines elicit stronger and longer immune responses
than conventional vaccines.
3 - Induce neutralizing antibody responses to both primary and
conformational epitopes
4 - The VLP vaccines are cell-based using E. coli, insect cells
or fungi with much higher yield from 10-50 folds.
5 - Economical production, much shorter time for quick response
to urgent epidemics (about 2 months compared to the 6 mons-1year).
PreS1
PreS2
S
VLP Technologies
Virus
Cloning & expression
PreS1, PreS2 & S genes
HBV genome Virion
31. * Novel biomarkers for early detection of liver cancer
Glycan-3, GP73, HBV receptor & others
*Improved Methodologies (Nano particles)
Biomarkers for early detection of liver cancer
32.
33. Vietnam Biotechnology development
(In our experience from 1990s-present)
A- Characteristics
- Product-driven
- Establishing standardized biotechnology
- In search for development to make biotech a powerhouse for
modernizing Vietnam health care
B- Stages
- Initial stage (1995-2000): Acquaintance with biotech sciences, limited
application
- Progressive development (2000-2005): Gradual applications of
biotechnologies
- Rapid changes (2005-2010): Booming of ideas and research activities
34. The world incubator of biomedical
education & development
Prof. Herbert Boyer
Inventor of Biotechnology
Founder, Genentech Inc.
The Creation of Biotechnology (1973)
University of Califonria, San Francisco (UCSF)
Oncogene discoveries
48. Vietnam cell based therapeutic research are explored at various centers aims
toward both R&D and applications. The Gene Therapy Center was
established in Bach Mai Hospital, Ha Noi in 2009. It is the first center in Viet
Nam applying DNA technology to explore future treatments of genetic
disorders and cancers.
Cell-Gene Therapy Developments
49. Summary of Vietnam Biotech Progresses
1994 2014
PCR - Mass-Spec
- Protein/mAb
- Cell/Gene Therapy
- Need significant improvements for international standard, efficiency
- Require sustained government support
- Participation of advanced institutes abroad
- Open for partnerships and investments
50. BIOTECH POTENTIAL/OPPORTUNITY IN
VIETNAM
R&D
- Regenerative medicine
- Clinical studies with large selection
- Drug research & discovery
- Disease studies & Biomarkers
- Neutraceutical & Herbal research
Business
- Production/Manufacturing for cost saving
- Partnership/Investments for expansion
- Company distributors in Vietnam and SEA
regions
52. Proposal for future association/collaboration
A- ACADEMIC
1- Exchange Programs: students, faculties, research collaboration
2- Teaching and Research for Translational Medicine
B- R-D & CLINICAL STUDIES
1- Gene, cell and immunotherapies (liver cancer programs)
2- Clinical studies at hospitals & general population
C- OTHERS
1- Conference on Translational Medicine at UMP
2- Workshops & Trainings on specific topics
3- Publications
