Crohn,s disease
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Crohn's disease is a chronic, relapsing inflammatory condition of the intestines that results from the body's failure to regulate immune responses to normal gut bacteria in genetically susceptible individuals. Mutations in genes controlling innate immunity and regulators of acquired immunity predispose people to developing Crohn's when exposed to environmental triggers. Treatment focuses on suppressing inflammation with corticosteroids and surgery, while probiotics aim to maintain a healthy balance of gut microbes.
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Ratycz GFRP Research Statement Final
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Inactivating, or “knocking out,” a mutated gene that is functioning improperly.
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Crohn,s disease
- 1. BY: MOHAMMED AFFAF US SALEEM RIMS ADILABAD
- 2. CROHN’S DISEASE IS A CHRONIC,RELAPSING AND REMITTING DISEASE THAT INVOLVES TRANSMURAL INFLAMMATION OF THE INTESTINE. USUALLY CONFINED TO DISTAL SMALL INTESTINE AND COLON. THE DISEASE REFLECTS A FAILURE TO DOWN- REGULATE INFLAMMATORY RESPONSES TO NORMAL COMMENSAL MICROBIOTA.
- 3. IN GENETICALLY SUSCEPTIBLE INDIVIDUALS, MUTATIONS IN GENES CONTROLLING INNATE IMMUNE RESPONSE REGULATORS OF ACQUIRED IMMUNITY APPEARS TO PREDISPOSE TO DISEASE WHEN INDIVIDUALS ARE EXPOSED TO APPROPRIATE ENVIRONMENTAL FACTORS,
- 4. The pattern recognition receptors(PRRs) May be intracellular, such as the NOD protein One of the NOD protein the NOD-2 encoding gene may undergo mutation which leads to crohn’s disease
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