Regulatory Aspects associated to genome editing – U.S. Environmental Protecti...OECD Environment
In September 2016, EPA indicated in the National Strategy for Modernizing the Regulatory System for Biotechnology Products (put forward by the United States EPA, USDA, and FDA) that it intends to clarify its approach to pesticidal products derived from genome editing.
In this SlideShare, we're covering an overview on RNA technologies and recent applications in the field of life sciences. RNA is the pivotal ‘molecule of life’, involved in almost all aspects of cell biology. Recent successes in mRNA-based vaccines indicate just one of the near-infinite possibilities that RNA technology can offer in life sciences.
Regulatory Aspects associated to genome editing – U.S. Environmental Protecti...OECD Environment
In September 2016, EPA indicated in the National Strategy for Modernizing the Regulatory System for Biotechnology Products (put forward by the United States EPA, USDA, and FDA) that it intends to clarify its approach to pesticidal products derived from genome editing.
In this SlideShare, we're covering an overview on RNA technologies and recent applications in the field of life sciences. RNA is the pivotal ‘molecule of life’, involved in almost all aspects of cell biology. Recent successes in mRNA-based vaccines indicate just one of the near-infinite possibilities that RNA technology can offer in life sciences.
Japanese Regulatory Policy of Genome Editing Technologyapaari
Japanese Regulatory Policy of Genome Editing Technology by Takeshi Urao during the Regional Expert Consultation on Gene Editing in Agriculture and its Regulations Technical Session II
These slides highlight the approved & widely used therapeutics for treating COVID-19 patients (end Q1 2021). At the time of writing, there are 5 therapeutics that have been granted Emergency Use Authorization by the US FDA, mostly being antivirals and monoclonal antibodies (mAbs). The use of corticosteroids and cytokine inhibitors are also showing promise in their ability to reduce case fatalities, progression as well as hospitalization time.
"Global HIV Vaccine Market Future Outlook" Report Highlights:
Introduction to HIV Vaccines
Issues Related to the Development of HIV Vaccines
Parameters for Successful Commercialization of HIV Vaccines
Global HIV Vaccines Market Opportunity Analysis
Global HIV Vaccine Clinical Pipeline by Company & Phase
Global HIV Vaccine Clinical Pipeline: 100 Vaccines
Majority Vaccine in Preclinical Phase: 42 Vaccines
“Global Cancer Kinase Inhibitors Market & Pipeline Insight” Report Highlight:
Classification & Mechanism of Kinase Inhibitors
Cancer Kinase Inhibitors Therapy Market Overview
Cancer Kinase Inhibitors Therapy Pipeline by Phase, Indication, Company & Country
Marketed Cancer Kinase Inhibitors Therapy by Indication, Company & Country
Patent Analysis & Orphan Designation of Kinase Inhibitors
Cancer Kinase Inhibitors In Clinical Pipeline: 649 Drugs
Marketed Cancer Kinase Inhibitors: 35 Drugs
Gennaro D'Urso: PharmaDAO - The future of MedicineEdunomica
Gennaro D'Urso: PharmaDAO - The future of Medicine
DAO Camp 2022
Website: https://daocamp.org
Youtube: https://www.youtube.com/channel/UCeHtPZ_ZLZ-nHFMUCXY81RQ
FB: https://www.facebook.com/DAO-Camp-102442798988862/
"Global HIV Vaccine Market Future Outlook" Report Highlights:
Introduction to HIV Vaccines
Issues Related to the Development of HIV Vaccines
Parameters for Successful Commercialization of HIV Vaccines
Global HIV Vaccines Market Opportunity Analysis
Global HIV Vaccine Clinical Pipeline by Company & Phase
Global HIV Vaccine Clinical Pipeline: 100 Vaccines
Majority Vaccine in Preclinical Phase: 42 Vaccines
GERD is a day to day common problem, which is on the increase due to so many obvious reasons. It needs to be addressed to the public and the medical fraternity for proper management and treatment.
GERD (Gastro Esophageal Reflux Disease) is one of the commonest medical conditions found in the community today. GERD patients often suffer from frequent symptoms and require long term medication. However, how much of what we know about GERD is truly fact based on medical evidence? We challenge traditional paradigms to GERD
The company founder effectively life-hacked a $billion dollar OTC product and was awarded 6 patents for it. The funds raised were to prove efficacy and will probably be the only funding required before licensing.
We took a highly technical breifing and created a story that is both understandable and informative. We developed the brands, strategy, copy, graphics, and put together the deck and arranged key meetings with investors.
www.wildoutwest.com
Japanese Regulatory Policy of Genome Editing Technologyapaari
Japanese Regulatory Policy of Genome Editing Technology by Takeshi Urao during the Regional Expert Consultation on Gene Editing in Agriculture and its Regulations Technical Session II
These slides highlight the approved & widely used therapeutics for treating COVID-19 patients (end Q1 2021). At the time of writing, there are 5 therapeutics that have been granted Emergency Use Authorization by the US FDA, mostly being antivirals and monoclonal antibodies (mAbs). The use of corticosteroids and cytokine inhibitors are also showing promise in their ability to reduce case fatalities, progression as well as hospitalization time.
"Global HIV Vaccine Market Future Outlook" Report Highlights:
Introduction to HIV Vaccines
Issues Related to the Development of HIV Vaccines
Parameters for Successful Commercialization of HIV Vaccines
Global HIV Vaccines Market Opportunity Analysis
Global HIV Vaccine Clinical Pipeline by Company & Phase
Global HIV Vaccine Clinical Pipeline: 100 Vaccines
Majority Vaccine in Preclinical Phase: 42 Vaccines
“Global Cancer Kinase Inhibitors Market & Pipeline Insight” Report Highlight:
Classification & Mechanism of Kinase Inhibitors
Cancer Kinase Inhibitors Therapy Market Overview
Cancer Kinase Inhibitors Therapy Pipeline by Phase, Indication, Company & Country
Marketed Cancer Kinase Inhibitors Therapy by Indication, Company & Country
Patent Analysis & Orphan Designation of Kinase Inhibitors
Cancer Kinase Inhibitors In Clinical Pipeline: 649 Drugs
Marketed Cancer Kinase Inhibitors: 35 Drugs
Gennaro D'Urso: PharmaDAO - The future of MedicineEdunomica
Gennaro D'Urso: PharmaDAO - The future of Medicine
DAO Camp 2022
Website: https://daocamp.org
Youtube: https://www.youtube.com/channel/UCeHtPZ_ZLZ-nHFMUCXY81RQ
FB: https://www.facebook.com/DAO-Camp-102442798988862/
"Global HIV Vaccine Market Future Outlook" Report Highlights:
Introduction to HIV Vaccines
Issues Related to the Development of HIV Vaccines
Parameters for Successful Commercialization of HIV Vaccines
Global HIV Vaccines Market Opportunity Analysis
Global HIV Vaccine Clinical Pipeline by Company & Phase
Global HIV Vaccine Clinical Pipeline: 100 Vaccines
Majority Vaccine in Preclinical Phase: 42 Vaccines
GERD is a day to day common problem, which is on the increase due to so many obvious reasons. It needs to be addressed to the public and the medical fraternity for proper management and treatment.
GERD (Gastro Esophageal Reflux Disease) is one of the commonest medical conditions found in the community today. GERD patients often suffer from frequent symptoms and require long term medication. However, how much of what we know about GERD is truly fact based on medical evidence? We challenge traditional paradigms to GERD
The company founder effectively life-hacked a $billion dollar OTC product and was awarded 6 patents for it. The funds raised were to prove efficacy and will probably be the only funding required before licensing.
We took a highly technical breifing and created a story that is both understandable and informative. We developed the brands, strategy, copy, graphics, and put together the deck and arranged key meetings with investors.
www.wildoutwest.com
General Investor and partnership presentation for the launch of a new pharmaceutical product. Specifically funds the initial clinical trial and market tests.
This presentation and our commentary and responses to your questions may contain forward-looking statements, including comments concerning drug development programs, evaluation of potential opportunities, the level of corporate expenditures, the assessment of our technology by potential corporate partners, capital market conditions, timing of events, cash consumption and other subjects. Information concerning factors that could cause actual results to differ materially from those set forth in our regulatory filings from time to time.
Mandy Hagan - Advancing Technologies to Feed 9 BillionJohn Blue
Advancing Technologies to Feed 9 Billion - Mandy Hagan, Vice President, State Affairs and Grassroots, Grocery Manufacturers Association, from the 2015 Animal Agriculture Alliance Stakeholders Summit, The Journey to Extraordinary, May 6 - 7, 2015, Kansas City, MO, USA.
More presentations at http://www.trufflemedia.com/agmedia/conference/2015-the-journey-to-extraordinary
Happy to share this month’s edition of Nutrify Today magazine. This is no ordinary magazine that scraps internet data and presents to you some news. We hardly carry any news.
Our team carefully screens innovators from across the world and feature innovation of the month that is ready for goto market. Our technical team deeply analyzes latest patents being filed across the world on nutraceuticals and that would help you stay ahead with latest innovations evolving in various parts of the world.
This edition has innovations screened from Belgium-Sporobiotics to Japan- Nichi Glucans.
This edition has a transcript of an interview between our Editor and Chief – Sheldon Baker and business of interest to us.
All future editions will also be unique in the information being brought to you that can certainly impact your business progressively.
Trust me, these magazines are worth documenting as each edition will set standards for next edition.
If you have something interesting to share to the nutraceutical world then do write to us at hello@nutrifytoday.com
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
SURGICAL ANATOMY OF THE RETROPERITONEUM, ADRENALS, KIDNEYS AND URETERS.pptx
Coxmew gastroesophageal web
1. A NEW COMPOUND BY NANO BIOTECH
FOR
Gastro Esophageal Reflux Disease(GERD)
A Discovery Made By Nanosgroup
IN USA;
* About 44% of the US adult population have heartburn at least once a month
* 14% of Americans have symptoms weekly
* 7% have symptoms daily
mewasinghsandhu@hotmail.com- 609-902-7128
www.nanosgroup.com
Meda Biotech, USA
2. Opportunity
The global Gastro esophageal Reflux Disease
(GERD) market was worth $ 21.5 billion in 2009. It
is forecast to decline at a Compound Annual Growth
Rate (CAGR) of 8.7% for the next eight years to reach
$10.4 billion by 2017. The high projected rate of
decline is primarily attributable to the patent
expiries of all Proton Pump Inhibitors (PPIs) by the
end of the forecast period. Increase in the treatment
seeking population, the diagnosis population and
long term anti-reflux maintenance therapy are
expected to sustain the GERD market.
3. Proof of concept
A new drug developed for GERD
The drug releases at stomach where the environment
is acidic
As the formulation hits the acidic conditions, it
burst out to release the active molecule which
absorbed by the tissue to east out the acid reflux
conditions
While the drug is absorbed the local environment of
the stomach be eased out from acidic conditions too
4. COXTOIT- A Safe And Better Compound
COXTOIT
Nano-Technology for drug delivery and better absorption
IT WORKED
To ReliefEase on acid
6. Opportunity
It is estimated that GERD affects 25%–35% of the
population. Approximately 25 million adult
Americans have acid reflux, or heartburn, on a daily
basis, and more than 60 million Americans suffer
from heartburn at least once a month.
Main parent starting material is toxic for most of the
drugs in the market and end up with toxic drug. Our
parent molecule is not toxic and our drug is not toxic
too.
7. Mechanism of protection
Act on IL6 and IL8 for cell protection in the presence
of acid. COX 2 mechanism involvement
Prevents inflammation and ulcer caused by acid
production
Healing the cell damage
Reduces acidic environment
Result in healing the damage
8. Progress
POC>>>>>>>>>>>>>>>>>Established
R&D>>>>>>>>>>>>>>>>~ Completed
Pilot scale process>>>>>>> Established
Animal Trials>>>>>>>>>>10 dogs for 30 day
safety study
More than 100 people have used and Benefited
GMP production>>>>>>>> Needed
Clinical trials>>>>>>>.>>> Needed
Investment made so for over $1M
Patent Protection
9. Established
Raw material secured
Multiple batches reproduction in pilot scale
established
Safety study established (10 dogs for 30 days)
Efficacy (off record)
11. Plan to market/Exit
With sufficient fund the product will be generating
revenue in three years in some parts of the globe
In five years the product will be in USA market
cGMP and pre-clinical in
18 months
Phase-1 clinical in 9
months
Phase-2 and FDA
submission 18months
Sale in India , Bangla
desh and Dubai
Use of Data for USA
submission
Drug is for
multiple
uses