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Acid Reflux and GERD
1.
2. Do you want to go with this PPI Drugs?
Big Problem?
• PPI drugs proven to cause vitamin B12
deficiency
• Tuesday, December 17, 2013 by: PF Louis
Tags: PPI drugs, B12 deficiency, vitamin
supplements
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GERD/Acid Reflux
3. Big Problem
• According to a new study in the Journal of the
American Medical Association, proton pump
inhibitors (PPIs) and histamine 2 receptor
antagonists (H2RAs) suppress gastric acid
production, which can mean that the Vitamin B12 in
food is not properly absorbed into the body. Vitamin
B12 deficiency is linked to serious health
complications, such as anemia, nerve damage, and
dementia
• The most commonly used PPIs are
Prilosec, Prevacid, Nexium, Protonix, and Aciphex.
The most popular H2RAs include
Zantac, Pepcid, and Tagamet.
6. Market Size
• In recent years, GI prescriptions have remained
one of the world’s largest therapeutic markets,
with sales of more than $20 billion
• Given the large public need and the propensity for
high returns, the gastroenterology market is set to
expand. As an increasing pool of smaller
specialty pharmaceutical players recognize the
need and importance of developing innovative
treatments to restore normal function of the GI
system and improve patients’ quality of life, the
doors to improved GI health are opening, and
opportunity
7. Established
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A newly discovered compound
Proof of concept
No generic cliff
Patent protection
Pilot scale production
Raw material qualification
Manufacturing and QC protocols
Machinery identified
Formulation