The COVID-19 patient group continually studied by PRA serves as a baseline to understand the demographics of patients receiving the vaccine. Between April and May of this year, 13% of recently diagnosed COVID-19 patients received inpatient care, according to our report. Learn more.

1. COVID-19 Weekly Trend Insights
Compiled on 6/11/2021

2. • Global cases reached 174.5 million cases,
which represents an increase of 6% from
the last report.
• Over 3.7 million deaths have occurred
worldwide since the start of the pandemic.
• South American countries have seena
significant increase in cases, as Argentina
and Uruguay lead the surge.
Last report had data through week ending
5/28/2021
Confidential 2
Sources:
https://www.nytimes.com/interactive/2021/world/covid-cases.html
https://coronavirus.jhu.edu/map.html
Confirmed Cases
Worldwide
COVID-19 INSIGHTS
Confirmed Cases
174,570,342
Deaths
3,764,494
Total Vaccinations
~2,240,748,480

3. Confirmed Cases in the
USA
Confidential 3
COVID-19 INSIGHTS
• The rate of U.S. cases continues to level off,
as we observed an increase of 317K cases
(approximately 1%) since our last report.
• North Carolina garnered an increase in
deaths of 2.3% since our last report, the
highest among the top 10 states.
Last report had data through week ending
5/28/2021
Confirmed Cases
33,420,582
Deaths
598,355
Sources:
https://www.nytimes.com/interactive/2021/world/covid-cases.html
https://coronavirus.jhu.edu/map.html
State/Territory Confirmed Cases Case % Change Deaths Death % Change
California 3,799,010 0.6% 63,611 1.1%
Texas 2,971,646 1.1% 51,986 1.5%
Florida 2,329,859 0.9% 36,972 1.4%
New York 2,105,507 0.5% 52,914 -0.4%
Illinois 1,390,331 1.2% 25,413 1.7%
Pennsylvania 1,211,487 1.3% 27,472 1.8%
Ohio 1,105,720 0.8% 20,021 1.6%
Georgia 1,102,755 -1.5% 20,381 -1.4%
New Jersey 1,018,491 0.5% 26,309 0.9%
North Carolina 1,007,567 1.2% 13,252 2.3%

4. Confidential 4
Data Week 1 Current Year: June 12th, 2020
Data Week 52 Current Year: June 4th, 2021
Projected Retail, Unprojected Mail Order,
Projected LTC, All Other TRx Counts
NATIONAL TRENDS: Prescription activity continues to exceed 2020 pandemic trends
overall, dropping only as a consequence of the Memorial Day holiday with week ending
6/4/2021.
3-Year National Trends
(TRx)
Rolling 12 Weeks:
TRx % CHANGE COMPARED TO
PRIOR YEARS
Peak Pandemic
Response March
20th, 2020

5. COVID-19 Vaccine Administration:
Patient Demographic & Care Patterns
5
COVID-19 Special Report

6. Confidential 6
PFIZER 21 DAYS
MODERNA 28 DAYS
Covid-19 Vaccine Administration - Patient Demographics
PRA observed a sample of 43.79 M patients vaccinated from Nov 5, 2020, to June 4, 2021. This patient group serves as a baseline to understand the
demographics of patients receiving the Covid-19 Vaccine.
88% of the vaccine administrations in the sample have been distributed at a retail pharmacy.
PRA US patient longitudinally linked medical and hospital claims data, raw patient volumes
MEDIAN DAYS BETWEEN DOSES
UNIQUE PATIENTS VACCINATED PERCENT OF DISTRIBUTION
PATIENTS THAT HAVE RECEIVED THE COMPLETE
COURSE OF VACCINATION
PFIZER 24,121,952 55% 71.8%
MODERNA 16,495,669 38% 73.5%
JANSSEN 3,176,519 7%
CAVEAT - While extensive in capture of clinical activity of US patients, PRA’s database may not include some activity of patients, if their claims were not submitted
or captured in PRA’s data sources, accounting for difference in aggregated patient activity in comparison with public sources.

7. Confidential
Covid-19 Vaccine Administration - Patient Ages by Week
The average age of patients who have received the Covid-19 vaccine has been decreasing, with an increased in patients age group
10-19
7
PRA US patient longitudinally linked medical and hospital claims data, raw patient volumes

8. PRA leveraged insights from
Chronic Conditions Present in Covid-19
Vaccinated Patients
CAVEAT - This analysis is based on insights from our US Patient Real World Data to assess underlying conditions for patients that were administered the Covid-19 vaccine. Only the patients seen
in medical claims with at least 2 visits during the 18-month lookback period were eligible for evaluation. For the risk factor/chronic condition to be included, patients were required to have at
least 2 visits for the diagnosis in the 18-month look back period. PRA observed 19.2 M vaccinated patients eligible for analysis from Nov 5, 2020, to June 4, 2021.
Confidential
• 5.1 million vaccinated patients had at least 1 chronic condition.
• The most common chronic conditions were T2DM, Obesity, and Heart Disease
• Obesity was the most common in younger patients
• 22% of patients had a history of hypertension diagnosis
• 4% of patients had a history of Covid-19 diagnosis, prior to their first vaccine
administration
PRA US patient longitudinally linked medical and hospital claims data, raw patient volumes

9. COVID-19 Patient Monitoring:
Demographics & Treatments
Confidential 9
COVID-19: Overview of PRA Real World Data

10. Through patient activity observed for diagnosis, testing, exposure or symptoms of Covid-19 infection, PRA is tracking over 52M patients
overall and over 6.5M diagnosed patients in its US real world data during the time period from Feb 2, 2020, to June 2, 2021
Patients could report in multiple status categories based on claims captured and mapped to status
PRA US patient longitudinally linked medical and hospital claims data, raw patient volumes
PRA US Patient Real World Data COVID-19 Infection Trends

11. PRA is tracking 197,817 Covid-19 patients
during the most recent 4-week time period of
May 9, 2021- June 5, 2021
Among the Covid-19 diagnosed patients:
− Median age is 53
− 13% of the diagnosed patients had at least
one record of inpatient care for their
diagnosis.
PRA US patient longitudinally linked medical and hospital claims data, raw patient volumes
PRA US Patient Real World Data
COVID-19 Diagnosed
Patient Demographics
*Patients could be covered by
more than one payer type

12. Confidential
Covid-19 Weekly Trends- Inceptive Place of Care for Diagnosed Patients
There has been a decline in Covid-19 diagnosed patients, especially at Skilled Nursing Facilities since the Covid-19 vaccine rollout
12
PRA US patient longitudinally linked medical and hospital claims data, raw patient volumes
RECENT 4- WEEK AVERAGE
HOSPITAL INPATIENT 13%
HOSPITAL- ER 7%
OUTPATIENT 26%
OFFICE 23%
TELEHEALTH 7%
SKILLED NURSING 0%
URGENT CARE
FACILITY
13%
OTHER 10%

13. Confidential 13
Covid-19 Patients’ Acute Diagnosis by Week
PRA US patient longitudinally linked medical and hospital claims data, raw patient volumes
In the last 6 months, there has been a decline in respiratory failure, acute renal failure, sepsis, and hypoxemia

14. Confidential 14
Covid-19 Patients’ Symptoms by Week
In the last 6-months, symptom distribution have been relatively steady with the most common symptoms being cough, muscle and body aches, and
shortness of breath
PRA US patient longitudinally linked medical and hospital claims data, raw patient volumes

15. 15
Confidential
Treatments within 30 Days of
COVID-19 Diagnosis
PRA US patient longitudinally linked medical and hospital claims data, raw patient volumes
39%
58%
48%
44% 42%
38%
32%
27%
19%
40%
27%
35%
38% 39% 39% 38% 36%
32%
3%
10%
18% 17% 18%
15% 14%
11% 9%
1% 2%
8% 10% 11%
14% 16%
19%
22%
2% 2% 3% 4% 4% 5% 4% 3%
<=9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+
AZITHROMYCIN (38%) DEXAMETHASONE (38%) METHYLPREDNISOLONE (15%) REMDESIVIR (14%) BAMLANIVIMAB/ETESEVIMAB (4%)
Possible Treatments within 30 days of Covid-19
Diagnosis (all ages, N=25,313)
Possible Treatments by Age within 30 days of Covid-19 Diagnosis (N= 25,313)
PRA evaluated 25,313 Covid-19 diagnosed patients for observed use of possible
treatments within a 30- day window of Covid-19 diagnosis over the most recent 4-
week period of May 9,2021 to June 5, 2021
Azithromycin and dexamethasone continue to be most common treatments