COVID 19 and The Heart - Lessons Learnt from this Pandemic
Presentation by Dr Jeremy Chow
Cardiologist, Electrophysiologist
Asian Heart & Vascular Centre
www.ahvc.com.sg
This document discusses the cardiovascular manifestations and effects of COVID-19. Some key points:
- Cardiovascular disease is a common comorbidity in patients with COVID-19, SARS, and MERS. Myocardial injury is independently associated with high mortality in COVID-19 patients.
- SARS-CoV-2 binds to ACE2 receptors, which are highly expressed in heart, blood vessels and other organs. This disrupts the balance between protective and deleterious RAAS pathways.
- COVID-19 can cause direct damage to heart through ACE2 downregulation and indirect damage from cytokine release/coagulopathy. This leads to complications like myocarditis, heart failure, arrhythmias and
Covid 19 and the cardiovascular system implications for risk assessment dia...Ramachandra Barik
The novel coronavirus disease (COVID-19) outbreak, caused by SARS-CoV-2, represents the greatest medical challenge in decades. We provide a comprehensive review of the clinical course of COVID-19, its comorbidities, and
mechanistic considerations for future therapies. While COVID-19 primarily affects the lungs, causing interstitial
pneumonitis and severe acute respiratory distress syndrome (ARDS), it also affects multiple organs, particularly the
cardiovascular system. Risk of severe infection and mortality increase with advancing age and male sex. Mortality is
increased by comorbidities: cardiovascular disease, hypertension, diabetes, chronic pulmonary disease, and cancer.
The most common complications include arrhythmia (atrial fibrillation, ventricular tachyarrhythmia, and ventricular
fibrillation), cardiac injury [elevated highly sensitive troponin I (hs-cTnI) and creatine kinase (CK) levels], fulminant
myocarditis, heart failure, pulmonary embolism, and disseminated intravascular coagulation (DIC). Mechanistically,
SARS-CoV-2, following proteolytic cleavage of its S protein by a serine protease, binds to the transmembrane
angiotensin-converting enzyme 2 (ACE2) —a homologue of ACE—to enter type 2 pneumocytes, macrophages,
perivascular pericytes, and cardiomyocytes. This may lead to myocardial dysfunction and damage, endothelial dysfunction, microvascular dysfunction, plaque instability, and myocardial infarction (MI). While ACE2 is essential for viral invasion, there is no evidence that ACE inhibitors or angiotensin receptor blockers (ARBs) worsen prognosis.
Hence, patients should not discontinue their use. Moreover, renin–angiotensin–aldosterone system (RAAS) inhibitors might be beneficial in COVID-19. Initial immune and inflammatory responses induce a severe cytokine storm
[interleukin (IL)-6, IL-7, IL-22, IL-17, etc.] during the rapid progression phase of COVID-19. Early evaluation and
continued monitoring of cardiac damage (cTnI and NT-proBNP) and coagulation (D-dimer) after hospitalization
may identify patients with cardiac injury and predict COVID-19 complications. Preventive measures
1. HIV was first described in 1981 and is caused by HIV-1 and HIV-2 viruses which deplete CD4 lymphocytes. As of 2000, 58 million people were infected globally and 21.8 million had died.
2. Cardiac manifestations are common in HIV/AIDS patients, occurring in 28-73% of patients. Prior to antiretroviral therapy, cardiac disease was usually only detected at autopsy.
3. Guidelines recommend regular echocardiograms to monitor cardiac dysfunction in HIV patients, with increased frequency if abnormalities are detected. Endocarditis prevalence is increased in HIV patients.
Percutaneous Balloon Mitral Valvuloplasty (PBMV) is a procedure to dilated the mitral valve in the setting of rheumatic mitral valve stenosis. A catheter is inserted into the femoral vein, advanced to the right atrium and across the interatrial septum. Then the mitral valve is crossed with a balloon and it is inflated to relieve the fusion of the mitral valve commissures effectively acting to increase the mitral valve area and reduce the degree of mitral stenosis. Mitral regurgitation is a potential complication and thus PBMV is contraindicated if moderate or severe regurgitation is present. The Wilkins score examines mitral valve morphology and is determined via echocardiography to assess the likelihood of using PBMV based on certain echocardiographic criteria.
This document outlines an introduction to pulmonary hypertension including its epidemiology, etiology, pathogenesis, clinical features, treatment, and future directions. It defines pulmonary hypertension and notes the most common causes are lung diseases like COPD. In Nigeria, common causes include COPD, tuberculosis, connective tissue diseases, and sickle cell disease. The pathogenesis involves remodeling of the pulmonary vasculature from factors like endothelial dysfunction and an imbalance of vasoconstrictors and vasodilators. Over time, this can lead to right heart failure if the right ventricle can no longer compensate for the increased resistance.
HCM is a common genetic heart disease reported in populations globally
Inherited in an autosomal dominant pattern
The distribution of HCM is equal by sex, although women are diagnosed less commonly than men
The prevalence of unexplained asymptomatic hypertrophy in young adults has been reported to range from 1:200 to 1:500
This document discusses the cardiovascular manifestations and effects of COVID-19. Some key points:
- Cardiovascular disease is a common comorbidity in patients with COVID-19, SARS, and MERS. Myocardial injury is independently associated with high mortality in COVID-19 patients.
- SARS-CoV-2 binds to ACE2 receptors, which are highly expressed in heart, blood vessels and other organs. This disrupts the balance between protective and deleterious RAAS pathways.
- COVID-19 can cause direct damage to heart through ACE2 downregulation and indirect damage from cytokine release/coagulopathy. This leads to complications like myocarditis, heart failure, arrhythmias and
Covid 19 and the cardiovascular system implications for risk assessment dia...Ramachandra Barik
The novel coronavirus disease (COVID-19) outbreak, caused by SARS-CoV-2, represents the greatest medical challenge in decades. We provide a comprehensive review of the clinical course of COVID-19, its comorbidities, and
mechanistic considerations for future therapies. While COVID-19 primarily affects the lungs, causing interstitial
pneumonitis and severe acute respiratory distress syndrome (ARDS), it also affects multiple organs, particularly the
cardiovascular system. Risk of severe infection and mortality increase with advancing age and male sex. Mortality is
increased by comorbidities: cardiovascular disease, hypertension, diabetes, chronic pulmonary disease, and cancer.
The most common complications include arrhythmia (atrial fibrillation, ventricular tachyarrhythmia, and ventricular
fibrillation), cardiac injury [elevated highly sensitive troponin I (hs-cTnI) and creatine kinase (CK) levels], fulminant
myocarditis, heart failure, pulmonary embolism, and disseminated intravascular coagulation (DIC). Mechanistically,
SARS-CoV-2, following proteolytic cleavage of its S protein by a serine protease, binds to the transmembrane
angiotensin-converting enzyme 2 (ACE2) —a homologue of ACE—to enter type 2 pneumocytes, macrophages,
perivascular pericytes, and cardiomyocytes. This may lead to myocardial dysfunction and damage, endothelial dysfunction, microvascular dysfunction, plaque instability, and myocardial infarction (MI). While ACE2 is essential for viral invasion, there is no evidence that ACE inhibitors or angiotensin receptor blockers (ARBs) worsen prognosis.
Hence, patients should not discontinue their use. Moreover, renin–angiotensin–aldosterone system (RAAS) inhibitors might be beneficial in COVID-19. Initial immune and inflammatory responses induce a severe cytokine storm
[interleukin (IL)-6, IL-7, IL-22, IL-17, etc.] during the rapid progression phase of COVID-19. Early evaluation and
continued monitoring of cardiac damage (cTnI and NT-proBNP) and coagulation (D-dimer) after hospitalization
may identify patients with cardiac injury and predict COVID-19 complications. Preventive measures
1. HIV was first described in 1981 and is caused by HIV-1 and HIV-2 viruses which deplete CD4 lymphocytes. As of 2000, 58 million people were infected globally and 21.8 million had died.
2. Cardiac manifestations are common in HIV/AIDS patients, occurring in 28-73% of patients. Prior to antiretroviral therapy, cardiac disease was usually only detected at autopsy.
3. Guidelines recommend regular echocardiograms to monitor cardiac dysfunction in HIV patients, with increased frequency if abnormalities are detected. Endocarditis prevalence is increased in HIV patients.
Percutaneous Balloon Mitral Valvuloplasty (PBMV) is a procedure to dilated the mitral valve in the setting of rheumatic mitral valve stenosis. A catheter is inserted into the femoral vein, advanced to the right atrium and across the interatrial septum. Then the mitral valve is crossed with a balloon and it is inflated to relieve the fusion of the mitral valve commissures effectively acting to increase the mitral valve area and reduce the degree of mitral stenosis. Mitral regurgitation is a potential complication and thus PBMV is contraindicated if moderate or severe regurgitation is present. The Wilkins score examines mitral valve morphology and is determined via echocardiography to assess the likelihood of using PBMV based on certain echocardiographic criteria.
This document outlines an introduction to pulmonary hypertension including its epidemiology, etiology, pathogenesis, clinical features, treatment, and future directions. It defines pulmonary hypertension and notes the most common causes are lung diseases like COPD. In Nigeria, common causes include COPD, tuberculosis, connective tissue diseases, and sickle cell disease. The pathogenesis involves remodeling of the pulmonary vasculature from factors like endothelial dysfunction and an imbalance of vasoconstrictors and vasodilators. Over time, this can lead to right heart failure if the right ventricle can no longer compensate for the increased resistance.
HCM is a common genetic heart disease reported in populations globally
Inherited in an autosomal dominant pattern
The distribution of HCM is equal by sex, although women are diagnosed less commonly than men
The prevalence of unexplained asymptomatic hypertrophy in young adults has been reported to range from 1:200 to 1:500
The document discusses various techniques for assessing myocardial viability, including stress echocardiography, single photon emission computed tomography (SPECT), positron emission tomography (PET), and cardiac magnetic resonance imaging (MRI). Stress echocardiography evaluates contractile reserve through techniques like dobutamine stress echocardiography. SPECT assesses viability by detecting thallium or technetium uptake, which relies on intact cell membranes. PET detects FDG uptake indicating active glucose metabolism. MRI evaluates viability through detection of late gadolinium enhancement, indicating scar tissue, and can also assess contractile reserve with stress MRI. A combined approach utilizing multiple techniques can provide complementary information on viability.
A cardiologists perspective to current scenario in light of corona pandemic in india and world wide. cardiac procedures , heart disease , aceinhibitors , arni , heart failure , troponin, nt probnp
A Practical Approach to the Management of Complications During Percutaneous C...vaibhavyawalkar
1. Abrupt vessel closure is one of the most common major complications during PCI, with an incidence of approximately 0.3%. It can be caused by dissection, thrombus formation, embolization, spasm, or air injection. Immediate treatment involves confirming guidewire position, treating underlying causes like dissection or thrombus, and considering emergency CABG if persistent.
2. Coronary perforation is most commonly caused by balloon or stent oversizing, occurring in around 0.5% of PCIs. Treatment depends on the Ellis grade but may include balloon tamponade, covered stents, coils, surgery. Grade I perforations sometimes resolve on their own.
3. Device embol
Contrast echocardiography uses microbubble ultrasound contrast agents to improve image quality. These microbubbles remain in the intravascular space and allow for assessment of cardiac structure, function, and perfusion. Second generation contrast agents use an inert gas encapsulated by albumin or phospholipid shells. They interact with ultrasound by reflecting at fundamental frequencies and resonating to produce harmonic frequencies. Continuous infusion provides steady contrast levels needed for perfusion assessment. Contrast echocardiography is a non-invasive technique that improves evaluation of the heart.
2015 ESC Guidelines on Infective Endocarditis ppt. by Dr Abhishek Rathore MDdrabhishekbabbu
The document summarizes guidelines for the management of infective endocarditis (IE). It recommends an endocarditis team approach in a reference center for complicated IE cases. It emphasizes the importance of early diagnosis, antibiotic therapy, and consideration of early surgery. It also discusses new recommendations for specific IE situations, antibiotic prophylaxis, surgical management, and the roles of imaging and multidisciplinary care in IE management.
Electrical storm refers to multiple episodes of ventricular tachycardia or ventricular fibrillation within a short period, typically 24 hours. The document discusses the various definitions of electrical storm and reviews its incidence, triggers, risk factors, types including monomorphic ventricular tachycardia and polymorphic ventricular tachycardia, differential diagnosis, evaluation and management. Electrical storm is a medical emergency requiring identification and treatment of its underlying causes.
LVNC is a rare genetic cardiomyopathy characterized by a spongy appearance of the myocardium due to incomplete compaction of the embryonic myocardium. It can present with heart failure, arrhythmias, or thromboembolism. Echocardiography and cardiac MRI are used to diagnose LVNC based on identifying a two-layered myocardium. Management involves treating heart failure and preventing thromboembolism with anticoagulation in high-risk patients. While the cause of LVNC is thought to be due to an arrest in normal myocardial compaction during embryonic development, the pathophysiology is not fully understood.
Guideline for management of Acute heart failure. This will be important tool to know the management of Acute heart failure. How to approach heart failure. Bwhuafuqub hsughsbvd. Jaydtgavwb. Jjoauywcdvhs. Juggbnsui. Djusgvwhhwhwbbw. Navgsyshhabaysyusbbvcchhhhuijbvfrtbvkjagsybx vxhsyuevsv. Ghu hctyubcf you jhysysftebshaishgs.
This document discusses various types of single ventricle heart defects where there is only one functioning ventricle pumping blood to both the lungs and body. It describes the different terms used to describe these hearts including single ventricle, univentricular heart, and double inlet ventricle. The most common type is double inlet left ventricle where both atria connect to a dominant left ventricle. Other types include double inlet right ventricle, absent atrioventricular connections, and a common atrioventricular valve. The document outlines the challenges these hearts face in maintaining adequate blood flow and oxygen levels to both circulations.
The document discusses the history and technique of transseptal puncture (TSP). It describes how TSP provides direct access to the left atrium and has become a routine skill for electrophysiologists performing procedures like atrial fibrillation ablation. The technique involves using a Brockenbrough needle and Mullins sheath inserted via the femoral or jugular vein to puncture the interatrial septum, usually at the fossa ovalis. Landmarks, equipment, steps of the procedure, challenges, and complications are reviewed in detail. The summary emphasizes the importance and increasing use of TSP as well as reviews key aspects of the technique and potential complications.
Brugada Syndrome and LQTS - the evidenceJunhao Koh
Brugada Syndrome and Long QT Syndrome are cardiac conditions that can cause abnormal heart rhythms and sudden cardiac death. For Brugada Syndrome, the key aspects of diagnosis, risk stratification, and management discussed include identifying type 1 ECG patterns, assessing risk based on exercise stress tests and signal-averaged ECGs, and treating high-risk patients with medications like quinidine or catheter ablation. For Long QT Syndrome, diagnosis involves measuring the corrected QT interval on ECG, risk stratification considers specific genetic mutations and history of syncope, and management relies on beta blockers and ICDs for high-risk patients. Both conditions require careful medical management to reduce risks of life-threatening arrhythmias.
Admixture lesions in congenital cyanotic heart diseaseRamachandra Barik
Admixture lesions in congenital cyanotic heart disease
Jaganmohan A Tharakan
Department of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India
Assessment of prosthetic valve functionSwapnil Garde
This document discusses the assessment of prosthetic valve function through various imaging modalities. It begins with an introduction to prosthetic valves and outlines topics to be covered, including classification of valve types. Evaluation methods like chest x-ray, fluoroscopy, echocardiography, and CT are described. Parameters assessed on each modality and guidelines for evaluation are provided. Complications of prosthetic valves and 3D imaging advances are also mentioned.
This document discusses atrioventricular septal defects (AVSDs). It begins with epidemiology, noting a prevalence of 4-5% of congenital heart defects. It then covers embryology, anatomy, pathology, classification, clinical features, diagnosis and management. Key points include abnormal development of endocardial cushions leading to absence of AV septum and common atrioventricular valves. Clinical features include congestive heart failure in infancy. Diagnosis is made via echocardiogram showing absent AV septum. Surgical repair aims to close defects and preserve left AV valve competence.
HCM – Presentation, Hemodynamics and InterventionAnkur Gupta
This document describes a case of a 50-year-old female presenting with symptoms of breathlessness, angina, and presyncope. Echocardiography revealed asymmetric septal hypertrophy and systolic anterior motion of the mitral valve, consistent with hypertrophic obstructive cardiomyopathy (HOCM). The document then provides detailed background information on HOCM, including definitions, pathophysiology, clinical presentation, diagnostic testing, and treatment options such as beta-blockers, septal ablation, and disqualification from competitive sports in severe cases.
This document provides information on coronary stents. It begins with an introduction to coronary artery disease and percutaneous angioplasty. It then discusses the history and development of stents, including bare metal stents which reduced restenosis compared to angioplasty alone but still had issues. Drug-eluting stents were developed using drugs like sirolimus and paclitaxel to further reduce restenosis. The document covers first-generation drug-eluting stents and limitations, as well as second-generation stents with improved polymers and drugs that showed better outcomes than first-generation stents in clinical trials. Specific second-generation stent platforms are discussed.
This document discusses low flow, low gradient aortic stenosis. It begins by introducing aortic stenosis and its prevalence. It then outlines the different types of low flow, low gradient aortic stenosis, including those with low ejection fraction and those with normal ejection fraction. For those with low EF, the document discusses the pathophysiology, importance of distinguishing true from pseudo-severe stenosis, and role of dobutamine stress echocardiography in making this distinction. It provides details on dobutamine stress echo protocol and parameters used to identify true severe stenosis versus pseudosevere stenosis.
This document discusses percutaneous mitral valve interventions for mitral regurgitation. It begins by describing the anatomy of the mitral valve and causes of mitral regurgitation. It then discusses the natural history of mitral regurgitation and indications for surgery. Current percutaneous options are described including the MitraClip device, which is the only FDA approved one. The MitraClip procedure involves grasping the leaflets edges to reduce regurgitation. Early results show high rates of procedural success for MitraClip in patients at high risk for surgery. Complications are usually low at 15-19% and include bleeding, partial clip detachment, and stroke.
Left ventricular free-wall rupture is one of the most fatal complications after acute myocardial infarction. Surgical
treatment of post-infarction left ventricular free-wall rupture has evolved over time. Direct closure of the ventricular
wall defect (linear closure) and resection of the infarcted myocardium (infarctectomy), with subsequent closure of the
created defect with a prosthetic patch, represented the original techniques. Recently, less aggressive approaches, either
with the use of surgical glues or the application of collagen sponge patches on the infarct area to cover the tear and
achieve haemostasis, have been proposed. Despite such modifications in the therapeutic strategy and surgical treatment,
however, postoperative in-hospital mortality may be as high as 35%. In extremely high-risk or inoperable patients, a nonsurgical approach has been reported
Covid Pathophysiology and clinical featuresNaveen Kumar
The document summarizes the pathophysiology of COVID-19. It discusses that SARS-CoV-2 enters cells through the ACE2 receptor and causes a cytokine storm. This can lead to organ damage and failure. Symptoms range from mild to severe and include fever, cough and shortness of breath. Those at highest risk are the elderly, immunocompromised, and those with pre-existing conditions like heart or lung disease. The clinical severity is classified as mild, moderate or severe based on symptoms and oxygen levels.
This document describes a case of fulminant myocarditis likely caused by COVID-19 infection in a 59-year-old woman. Key points:
- The patient presented with fever and chest pain but no respiratory symptoms. Tests confirmed SARS-CoV-2 infection and showed signs of cardiac injury.
- Echocardiograms showed myocardial thickening, edema, and dysfunction. She deteriorated into cardiogenic shock requiring interventions.
- Treatment for suspected acute myocarditis included immunoglobulins, steroids, and antivirals. Cardiac function improved but she required ongoing ECMO support for respiratory issues.
- This case suggests that in rare cases, COVID-19 can cause severe myocarditis
The document discusses various techniques for assessing myocardial viability, including stress echocardiography, single photon emission computed tomography (SPECT), positron emission tomography (PET), and cardiac magnetic resonance imaging (MRI). Stress echocardiography evaluates contractile reserve through techniques like dobutamine stress echocardiography. SPECT assesses viability by detecting thallium or technetium uptake, which relies on intact cell membranes. PET detects FDG uptake indicating active glucose metabolism. MRI evaluates viability through detection of late gadolinium enhancement, indicating scar tissue, and can also assess contractile reserve with stress MRI. A combined approach utilizing multiple techniques can provide complementary information on viability.
A cardiologists perspective to current scenario in light of corona pandemic in india and world wide. cardiac procedures , heart disease , aceinhibitors , arni , heart failure , troponin, nt probnp
A Practical Approach to the Management of Complications During Percutaneous C...vaibhavyawalkar
1. Abrupt vessel closure is one of the most common major complications during PCI, with an incidence of approximately 0.3%. It can be caused by dissection, thrombus formation, embolization, spasm, or air injection. Immediate treatment involves confirming guidewire position, treating underlying causes like dissection or thrombus, and considering emergency CABG if persistent.
2. Coronary perforation is most commonly caused by balloon or stent oversizing, occurring in around 0.5% of PCIs. Treatment depends on the Ellis grade but may include balloon tamponade, covered stents, coils, surgery. Grade I perforations sometimes resolve on their own.
3. Device embol
Contrast echocardiography uses microbubble ultrasound contrast agents to improve image quality. These microbubbles remain in the intravascular space and allow for assessment of cardiac structure, function, and perfusion. Second generation contrast agents use an inert gas encapsulated by albumin or phospholipid shells. They interact with ultrasound by reflecting at fundamental frequencies and resonating to produce harmonic frequencies. Continuous infusion provides steady contrast levels needed for perfusion assessment. Contrast echocardiography is a non-invasive technique that improves evaluation of the heart.
2015 ESC Guidelines on Infective Endocarditis ppt. by Dr Abhishek Rathore MDdrabhishekbabbu
The document summarizes guidelines for the management of infective endocarditis (IE). It recommends an endocarditis team approach in a reference center for complicated IE cases. It emphasizes the importance of early diagnosis, antibiotic therapy, and consideration of early surgery. It also discusses new recommendations for specific IE situations, antibiotic prophylaxis, surgical management, and the roles of imaging and multidisciplinary care in IE management.
Electrical storm refers to multiple episodes of ventricular tachycardia or ventricular fibrillation within a short period, typically 24 hours. The document discusses the various definitions of electrical storm and reviews its incidence, triggers, risk factors, types including monomorphic ventricular tachycardia and polymorphic ventricular tachycardia, differential diagnosis, evaluation and management. Electrical storm is a medical emergency requiring identification and treatment of its underlying causes.
LVNC is a rare genetic cardiomyopathy characterized by a spongy appearance of the myocardium due to incomplete compaction of the embryonic myocardium. It can present with heart failure, arrhythmias, or thromboembolism. Echocardiography and cardiac MRI are used to diagnose LVNC based on identifying a two-layered myocardium. Management involves treating heart failure and preventing thromboembolism with anticoagulation in high-risk patients. While the cause of LVNC is thought to be due to an arrest in normal myocardial compaction during embryonic development, the pathophysiology is not fully understood.
Guideline for management of Acute heart failure. This will be important tool to know the management of Acute heart failure. How to approach heart failure. Bwhuafuqub hsughsbvd. Jaydtgavwb. Jjoauywcdvhs. Juggbnsui. Djusgvwhhwhwbbw. Navgsyshhabaysyusbbvcchhhhuijbvfrtbvkjagsybx vxhsyuevsv. Ghu hctyubcf you jhysysftebshaishgs.
This document discusses various types of single ventricle heart defects where there is only one functioning ventricle pumping blood to both the lungs and body. It describes the different terms used to describe these hearts including single ventricle, univentricular heart, and double inlet ventricle. The most common type is double inlet left ventricle where both atria connect to a dominant left ventricle. Other types include double inlet right ventricle, absent atrioventricular connections, and a common atrioventricular valve. The document outlines the challenges these hearts face in maintaining adequate blood flow and oxygen levels to both circulations.
The document discusses the history and technique of transseptal puncture (TSP). It describes how TSP provides direct access to the left atrium and has become a routine skill for electrophysiologists performing procedures like atrial fibrillation ablation. The technique involves using a Brockenbrough needle and Mullins sheath inserted via the femoral or jugular vein to puncture the interatrial septum, usually at the fossa ovalis. Landmarks, equipment, steps of the procedure, challenges, and complications are reviewed in detail. The summary emphasizes the importance and increasing use of TSP as well as reviews key aspects of the technique and potential complications.
Brugada Syndrome and LQTS - the evidenceJunhao Koh
Brugada Syndrome and Long QT Syndrome are cardiac conditions that can cause abnormal heart rhythms and sudden cardiac death. For Brugada Syndrome, the key aspects of diagnosis, risk stratification, and management discussed include identifying type 1 ECG patterns, assessing risk based on exercise stress tests and signal-averaged ECGs, and treating high-risk patients with medications like quinidine or catheter ablation. For Long QT Syndrome, diagnosis involves measuring the corrected QT interval on ECG, risk stratification considers specific genetic mutations and history of syncope, and management relies on beta blockers and ICDs for high-risk patients. Both conditions require careful medical management to reduce risks of life-threatening arrhythmias.
Admixture lesions in congenital cyanotic heart diseaseRamachandra Barik
Admixture lesions in congenital cyanotic heart disease
Jaganmohan A Tharakan
Department of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India
Assessment of prosthetic valve functionSwapnil Garde
This document discusses the assessment of prosthetic valve function through various imaging modalities. It begins with an introduction to prosthetic valves and outlines topics to be covered, including classification of valve types. Evaluation methods like chest x-ray, fluoroscopy, echocardiography, and CT are described. Parameters assessed on each modality and guidelines for evaluation are provided. Complications of prosthetic valves and 3D imaging advances are also mentioned.
This document discusses atrioventricular septal defects (AVSDs). It begins with epidemiology, noting a prevalence of 4-5% of congenital heart defects. It then covers embryology, anatomy, pathology, classification, clinical features, diagnosis and management. Key points include abnormal development of endocardial cushions leading to absence of AV septum and common atrioventricular valves. Clinical features include congestive heart failure in infancy. Diagnosis is made via echocardiogram showing absent AV septum. Surgical repair aims to close defects and preserve left AV valve competence.
HCM – Presentation, Hemodynamics and InterventionAnkur Gupta
This document describes a case of a 50-year-old female presenting with symptoms of breathlessness, angina, and presyncope. Echocardiography revealed asymmetric septal hypertrophy and systolic anterior motion of the mitral valve, consistent with hypertrophic obstructive cardiomyopathy (HOCM). The document then provides detailed background information on HOCM, including definitions, pathophysiology, clinical presentation, diagnostic testing, and treatment options such as beta-blockers, septal ablation, and disqualification from competitive sports in severe cases.
This document provides information on coronary stents. It begins with an introduction to coronary artery disease and percutaneous angioplasty. It then discusses the history and development of stents, including bare metal stents which reduced restenosis compared to angioplasty alone but still had issues. Drug-eluting stents were developed using drugs like sirolimus and paclitaxel to further reduce restenosis. The document covers first-generation drug-eluting stents and limitations, as well as second-generation stents with improved polymers and drugs that showed better outcomes than first-generation stents in clinical trials. Specific second-generation stent platforms are discussed.
This document discusses low flow, low gradient aortic stenosis. It begins by introducing aortic stenosis and its prevalence. It then outlines the different types of low flow, low gradient aortic stenosis, including those with low ejection fraction and those with normal ejection fraction. For those with low EF, the document discusses the pathophysiology, importance of distinguishing true from pseudo-severe stenosis, and role of dobutamine stress echocardiography in making this distinction. It provides details on dobutamine stress echo protocol and parameters used to identify true severe stenosis versus pseudosevere stenosis.
This document discusses percutaneous mitral valve interventions for mitral regurgitation. It begins by describing the anatomy of the mitral valve and causes of mitral regurgitation. It then discusses the natural history of mitral regurgitation and indications for surgery. Current percutaneous options are described including the MitraClip device, which is the only FDA approved one. The MitraClip procedure involves grasping the leaflets edges to reduce regurgitation. Early results show high rates of procedural success for MitraClip in patients at high risk for surgery. Complications are usually low at 15-19% and include bleeding, partial clip detachment, and stroke.
Left ventricular free-wall rupture is one of the most fatal complications after acute myocardial infarction. Surgical
treatment of post-infarction left ventricular free-wall rupture has evolved over time. Direct closure of the ventricular
wall defect (linear closure) and resection of the infarcted myocardium (infarctectomy), with subsequent closure of the
created defect with a prosthetic patch, represented the original techniques. Recently, less aggressive approaches, either
with the use of surgical glues or the application of collagen sponge patches on the infarct area to cover the tear and
achieve haemostasis, have been proposed. Despite such modifications in the therapeutic strategy and surgical treatment,
however, postoperative in-hospital mortality may be as high as 35%. In extremely high-risk or inoperable patients, a nonsurgical approach has been reported
Covid Pathophysiology and clinical featuresNaveen Kumar
The document summarizes the pathophysiology of COVID-19. It discusses that SARS-CoV-2 enters cells through the ACE2 receptor and causes a cytokine storm. This can lead to organ damage and failure. Symptoms range from mild to severe and include fever, cough and shortness of breath. Those at highest risk are the elderly, immunocompromised, and those with pre-existing conditions like heart or lung disease. The clinical severity is classified as mild, moderate or severe based on symptoms and oxygen levels.
This document describes a case of fulminant myocarditis likely caused by COVID-19 infection in a 59-year-old woman. Key points:
- The patient presented with fever and chest pain but no respiratory symptoms. Tests confirmed SARS-CoV-2 infection and showed signs of cardiac injury.
- Echocardiograms showed myocardial thickening, edema, and dysfunction. She deteriorated into cardiogenic shock requiring interventions.
- Treatment for suspected acute myocarditis included immunoglobulins, steroids, and antivirals. Cardiac function improved but she required ongoing ECMO support for respiratory issues.
- This case suggests that in rare cases, COVID-19 can cause severe myocarditis
Patients with severe acute respiratory syndrome coronavirus 2 (SARS-Cov2) infection mainly present severe pneumonia associated with complications related to cytokine storm syndrome. So, it was associated with thrombotic incidents like acute limb ischemia and pulmonary embolism.
Patients with severe acute respiratory syndrome coronavirus 2 (SARS-Cov2) infection mainly present severe pneumonia associated with complications related to cytokine storm syndrome. So, it was associated with thrombotic incidents like acute limb ischemia and pulmonary embolism.
Patients with severe acute respiratory syndrome coronavirus 2
(SARS-Cov2) infection mainly present severe pneumonia associated with complications related to cytokine storm syndrome. So, it
was associated with thrombotic incidents like acute limb ischemia
and pulmonary embolism.
We report 3 cases of COVID-19 infection complicated by arterial
thrombosis in the form of acute limb ischemia.
Patients with severe acute respiratory syndrome coronavirus 2 (SARS-Cov2) infection mainly present severe pneumonia associated with complications related to cytokine storm syndrome. So, it was associated with thrombotic incidents like acute limb ischemia and pulmonary embolism.
This document provides an overview of the radiological presentation of COVID-19 based on CT scans and chest x-rays. It finds that ground glass opacities are the most common CT finding and often appear bilaterally in the lower lobes in a peripheral or subpleural distribution. Later stages may also show consolidation, septal thickening, and traction bronchiectasis. Chest x-rays are less sensitive than CT early on but can still detect signs of disease progression like bilateral opacities and consolidation. Pediatric cases tend to be milder with fewer abnormal CT findings. The document outlines typical features, frequencies of signs, and comparisons between adult and pediatric presentations.
A 67-year-old woman presented with respiratory symptoms and was diagnosed with COVID-19. One week later, she presented with worsening symptoms and was found to have a large hemorrhagic pericardial effusion causing cardiac tamponade. She underwent pericardiocentesis, draining 800ml of fluid. After the procedure, she developed signs of takotsubo cardiomyopathy. The case report discusses the rare presentation of cardiac tamponade secondary to COVID-19 infection and the subsequent development of takotsubo cardiomyopathy.
Transverse Myelitis in a Patient with COVID-19: A Case Reportkomalicarol
This case report describes a 45-year-old female who presented with transverse myelitis. MRI revealed abnormalities in her thoracic spinal cord. She tested positive for COVID-19 during workup. The patient did not improve with steroids but did improve after a course of plasmapheresis. This case suggests that COVID-19 should be considered as a potential cause of transverse myelitis, as the virus can cause neurological manifestations through various mechanisms. More research is still needed but physicians should be aware of unusual neurological presentations potentially associated with COVID-19 infection.
Karaganda medical university discusses Covid-19 neurological complications. It begins with an introduction to SARS-CoV-2 and its structure. It then discusses the virus's pathogenesis and transmission through ACE2 receptors. Common clinical features are fever, cough and loss of smell or taste. The virus can reach the brain through olfactory neurons or disrupting the blood brain barrier. Neurological complications discussed include anosmia, meningitis, encephalitis, stroke, Guillain-Barré syndrome and epilepsy. Diagnosis and treatment of each condition is explained. The conclusion emphasizes prevention of complications and treating underlying conditions.
The document discusses COVID-19 and its impact on the cardiovascular system. It covers the epidemiology of COVID-19 and how it can lead to myocardial infarction through several pathways. The pathophysiology involves three phases - early infection, pulmonary, and hyperinflammation - that can result in direct myocardial injury, cytokine storm, or stress-induced cardiomyopathy. Those at highest risk are the elderly, those with pre-existing cardiovascular conditions, and those with other comorbidities. Assessment of cardiac issues in COVID-19 patients involves evaluating symptoms like chest pain and dyspnea, as well as diagnostic tests. Management depends on the specific cardiovascular presentation, such as protocols for STEMI patients or those with cardiogenic shock.
A 58-year-old woman was admitted with COVID-19 symptoms and developed cardiogenic and septic shock. An echocardiogram showed findings consistent with takotsubo cardiomyopathy - also known as stress cardiomyopathy - with left ventricular dysfunction. Her left ventricular function improved over the next few days, supporting the diagnosis of reversible acute stress cardiomyopathy secondary to COVID-19. This is the first reported case of takotsubo cardiomyopathy associated with COVID-19 in the United States.
The severe acute respiratory syndrome-coronavirus-2-caused coronavirus disease-2019 (COVID-19) has arisen as a serious worldwide public health adversity. Early in the COVID-19 pandemic, an increased incidence of arterial and venous thrombosis was found, linked to systemic inflammation, immobilization, and a prothrombotic environment. Venous thromboembolism (VTE) can manifest itself in a variety of ways. A 55-year-old man presented to the emergency department with peripheral arterial disease (PAD) history.
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This document discusses management of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19. MIS-C is a rare condition that can occur in children 2-6 weeks after SARS-CoV-2 infection. It involves inflammation of multiple organs and can cause symptoms like fever, rash, gastrointestinal issues, and cardiac involvement. The document outlines the epidemiology, pathophysiology, clinical manifestations, diagnostic evaluation, treatment including medications like IVIG and steroids, and follow-up care of MIS-C. Treatment is aimed at reducing inflammation and involves IVIG, steroids, aspirin, and enoxaparin in severe cases.
The document describes 4 cases of COVID-19-associated pneumothorax reported at a hospital in Brazil. Pneumothorax is a rare complication of COVID-19 that can occur when patients are asymptomatic or have improving symptoms. The cases included patients ranging from 22 to 84 years old, with pneumothoraces detected on imaging during or after recovery from COVID-19. COVID-19 can cause lung damage that leads to air leaks and pneumothorax. Physicians need to be aware of this potential complication in COVID-19 patients.
Dresslers syndrome should be considered in the differential diagnosis of chest pain, especially in patients at late stages of the progression of the ischemic process. Myocardial rupture is a rare event often associated with sudden death after myocardial infarction. This case report describes the 56 years age old man who present in persistent chest pain with radiating in shoulder and breathlessness with high grade fever. He had previously myocardial infraction in one month back and treated with reperfusion therapy and also history of hypertension and type 2 diabetes mellitus under medications. He finally diagnosed in evidence of ECG and CT findings. K Karpagam | Deepan M "Dressler’s Syndrome: Case Report" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-1 , February 2023, URL: https://www.ijtsrd.com/papers/ijtsrd53868.pdf Paper URL: https://www.ijtsrd.com/medicine/other/53868/dressler’s-syndrome-case-report/k-karpagam
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COVID 19 and The Heart - Lessons Learnt from this Pandemic
1. COVID-19 and The Heart -
Lessons Learnt from this Pandemic
PRESENTED BY:
DR JEREMY CHOW
Consultant Cardiologist & Electrophysiologist
Director of Electrophysiology Service
MBBS, MRCP (UK), MRCP (London), M Med (Int Med)
FAMS, FESC, FHRS
Certified Cardiac Device Specialist
Website:www.ahvc.com.sg
Email: drchow.jeremy@ahvc.com.sg
ZOOM SEMINAR
4. Overview
Covid 19 infection- 3 stages of the Disease
COVID 19 and cardiac consequences /
complications
Should our cardiac patients consider
vaccination?
Is COVID Vaccine 100% effective and safe?
5.
6.
7. 3 stages of COVID 19 infection
Stage 1 - mild and early, mainly flu
symptoms and resolved in 80%
Stage 2 - moderate disease with lung
involvement “ COVID Pneumonia”
Stage 3 - severe and systemic disease
due to hyper-inflammation
Most cardiac complications occur here
25. COVID Case (From RH)
40 year old Male
No medical history
Came to hospital for chest pain and
breathlessness
He was also having fever at 38C
At A&E, he was confused with SpO2 96% on
NRM
COVID PCR +
28. COVID Case (From Gleneagles)
81 year old Male
No medical history. COVID Vaccinated in July
Transferred from CCF to us for COVID
Pneumonia
He was transferred to ICU for progressive
dyspnoea with new onset AF with ECG
showing ST elevation
Trop T 29.1 -> 36 pg/mL, normal CKMB <5
ng/mL
39. Case 1
50 year old Male
No medical history
Went for COVID vaccination (Pfizer) on 9
April 2021
4 days later had palpitation and irregular
heart beat.
He saw his GP and did ECG and was
referred to A&E.
41. Case 1
He was sent home from A&E after
spontaneously reverted to sinus rhythm and
was started on Concor.
3 days later he was admitted for expressive
aphasia in NUH.
CT Head was normal and his symptoms
resolved in 24 hours —> TIA
So he came to see me for second opinion
for long term anticoagulation
45. Case 2
45 year old Male
No medical history
Completed COVID vaccination (Pfizer) x 2
uneventful in February.
Went for Booster (Pfizer) on 17 September
Complained of sudden onset chest pain on 21
October with radiation to jaw and dyspnoea.
He saw his GP and did ECG and was referred
to A&E.
48. Case 2
ECG showed ST elevation MI? in inferior
lateral territory
Coronary angiogram done showed normal
coronaries
What did the labs show?
Trop T 1033->1133 -> 733
CKMB 66 -> 17 -> 3.6
ESR 21, CRP <4
56. Take Home Message….
COVID-19 is not going to go away!
Cardiac complications are common with
COVID infection.
Our index of suspicion for must be high
for post COVID vaccination complication.
Overall vaccination confers more
protection than risk!
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ANNEXE BLOCK
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Thank You and
Stay Safe