FarGen aims to implement whole genome sequencing for the entire population of 50,000 people in the Faroe Islands. This will provide a foundation for personalized healthcare focused on prevention and treatment, and establish an infrastructure for research. A pilot study of 100 individuals will test the workflow and monitor the scientific, technical, ethical and social impacts. This initiative aims to develop genomic medicine that benefits both the Faroese population and has global applicability, while respecting ethical standards like informed consent and individual rights.
A retrospective analysis of deep neck infection patients profile in p.stradin...Linda Veidere
RSU MF studentu Lindas Veideres un Marka Roņa pētījums. Uzstājās Rīga Stradiņš University Student International Conference "Health and Social Sciences" 2015 un 3rd International Helath Sciences Conference Lietuvā.
Prehospital rapid sequence intubation improves functional outcome for patient...Emergency Live
In adults with severe TBI, prehospital rapid sequence intubation by paramedics increases the rate of favorable neurologic outcome at 6 months compared with intubation in the hospital.
A retrospective analysis of deep neck infection patients profile in p.stradin...Linda Veidere
RSU MF studentu Lindas Veideres un Marka Roņa pētījums. Uzstājās Rīga Stradiņš University Student International Conference "Health and Social Sciences" 2015 un 3rd International Helath Sciences Conference Lietuvā.
Prehospital rapid sequence intubation improves functional outcome for patient...Emergency Live
In adults with severe TBI, prehospital rapid sequence intubation by paramedics increases the rate of favorable neurologic outcome at 6 months compared with intubation in the hospital.
Assessment of Traditional Medicinal Plants Used for Treatment of Human Diseas...Chala Dandessa
Assessment of Traditional Medicinal Plants Used for
Treatment of Human Diseases in Oromia Region,
West Shewa Zone: Jeldu Woreda, Ethiopia, Published article on Asian Plant Research Journal.
Evaluation of the safety of conventional lighting replacement by artificial d...Prof. Hesham N. Mustafa
Background
Short morning exposure to high illuminance visible electromagnetic radiations termed as artificial daylight is beneficial for the mental health of people living in geographical areas with important seasonal changes in daylight illuminance. However, the commercial success of high illuminance light sources has raised the question of the safety of long hour exposure.
Methods
We have investigated the effect of the replacement of natural daylight by artificial daylight in Swiss mice raised under natural lighting conditions. Mice were monitored for neurotoxicity and general health changes. They were submitted to a battery of conventional tests for mood, motor and cognitive functions’ assessment on exposure day (ED) 14 and ED20. Following sacrifice on ED21 due to marked signs of neurotoxicity, the expression of markers of inflammation and apoptosis was assessed in the entorhinal cortex and neurons were estimated in the hippocampal formation.
Results
Signs of severe cognitive and motor impairments, mood disorders, and hepatotoxicity were observed in animals exposed to artificial daylight on ED20, unlike on ED14 and unlike groups exposed to natural daylight or conventional lighting. Activated microglia and astrocytes were observed in the entorhinal cortex, as well as dead and dying neurons. Neuronal counts revealed massive neuronal loss in the hippocampal formation.
Conclusions
These results suggest that long hour exposure to high illuminance visible electromagnetic radiations induced severe alterations in brain function and general health in mice partly mediated by damages to the neocortex-entorhinal cortex-hippocampus axis. These findings raise caution over long hour use of high illuminance artificial light.
Huong dan dat ve may bay gia re cac hang VIETNAM AIRLINES, JETSTAR, VIETJET AIR – VNTIC.VN
Ve may bay tu TPHCM - HA NOI - Đà Nẵng - Thanh Hóa - Huế - Đồng hới - Nha Trang - Chu Lai - Singapore - BangKok - Seoul
An overview of the Companies Act 2014 as it pertains to Irish registered limited companies, with the information and practical knowledge necessary to ensure that such companies comply with the Act.
Selamat berjumpa melalui majalah digital POTENTIA edisi ketigabelas, yang merupakan sarana komunikasi bagi kita semua untuk melakukan refleksi atas perjalanan karya kita sepanjang tahun 2016. Apakah kita semua telah mengisi kehidupan ini dengan sesuatu yang berkualitas dan berdampak bagi kehidupan sesama?
Tema “Sambut Era Baru” yang diusung pada edisi kali ini menandai berakhirnya tahapan pengembangan I peziarahan universitas ini (tahun 2011-2015) dan dimulainya tahapan pengembangan II (tahun 2016-2020) dari Rencana Induk Pengembangan (RIP) Universitas Katolik Widya Mandala Surabaya (UKWMS) tahun 2011-2025. Saatnya bagi institusi ini untuk ‘go to the next level and to the next landscape’ melalui pergantian jajaran kepemimpinan yang baru di semua jenjang. Pada akhir periode RIP, UKWMS diharapkan menjadi sebuah Perguruan Tinggi unggulan yang mampu menjadi mediasi transendental bagi sekelompok individu yang tersusun atas tubuh, jiwa, dan roh, untuk secara kolektif dapat melaksanakan transformasi sosial bagi masyarakat Indonesia.
Untuk mewujudkan mimpi tersebut, saya mengajak semua pihak bersikap pro-aktif. Cermati karakteristik dari masing-masing nilai keutamaan Universitas, PeKA: (1) Peduli: aktif ikut bagian dalam setiap kegiatan; (2) Komit: kesediaan untuk berbuat yang sejauh mungkin … “beyond the call of duty”; (3) Antusias: sikap amat bergairah, sangat berminat, dan bersemangat berapi-api dalam setiap tugas dan kegiatan, tidak ada rasa keterpaksaan, bahkan (serasa) selalu ingin melaksanakannya. Ekspresi lahiriah dari semuanya itu teramati pada torehan prestasi cemerlang dari dosen, tenaga kependidikan, mahasiswa, dan alumni yang berkarya dan studi di UKWMS, seperti diulas pada majalah ini. Hal ini semakin dipertegas dengan diraihnya Akreditasi Institusi Perguruan Tinggi dengan peringkat A dan tercatatnya UKWMS sebagai salah satu institusi yang termuat di dalam Buku Profil Peringkat 50 Besar Kekuatan Institusi Ilmiah Indonesia.
Bagi para pembaca di luar lingkungan Universitas, selamat mengecap dan menikmati suasana akademik yang kondusif di kampus kehidupan ini. Semoga dapat menginspirasi kehidupan anda sekalian untuk mau menjadi pribadi yang lebih baik sehingga kehidupan anda lebih berdampak positif bagi sesama.
Semoga kampus ini terasa semakin dekat dengan masyarakat dan selalu berada di hati masyarakat.
Tuhan Yang Maha Pengasih dan Maha Penyayang senantiasa memberkati kita semua.
Solid Car Rental Costa Rica rent a car costa ricaSolid Car Rental
Solid Car Rental Costa Rica esta preparada para hacer su experiencia de alquiler de coches tan simple, agradable y emocionante como sea posible, al mismo tiempo que proporciona el mejor valor en los servicios de alquiler de coches.
Fireside Chat with Sander Arts of Atmel: The Journey to Account-Based Marketi...G3 Communications
From the B2B Content2Conversion Conference, with:
Panelists:
-Chris Golec, CEO of Demandbase
-Sander Arts, VP, Corporate Marketing, Atmel
-Jen Gray, Director of Marketing, Extole
Assessment of Traditional Medicinal Plants Used for Treatment of Human Diseas...Chala Dandessa
Assessment of Traditional Medicinal Plants Used for
Treatment of Human Diseases in Oromia Region,
West Shewa Zone: Jeldu Woreda, Ethiopia, Published article on Asian Plant Research Journal.
Evaluation of the safety of conventional lighting replacement by artificial d...Prof. Hesham N. Mustafa
Background
Short morning exposure to high illuminance visible electromagnetic radiations termed as artificial daylight is beneficial for the mental health of people living in geographical areas with important seasonal changes in daylight illuminance. However, the commercial success of high illuminance light sources has raised the question of the safety of long hour exposure.
Methods
We have investigated the effect of the replacement of natural daylight by artificial daylight in Swiss mice raised under natural lighting conditions. Mice were monitored for neurotoxicity and general health changes. They were submitted to a battery of conventional tests for mood, motor and cognitive functions’ assessment on exposure day (ED) 14 and ED20. Following sacrifice on ED21 due to marked signs of neurotoxicity, the expression of markers of inflammation and apoptosis was assessed in the entorhinal cortex and neurons were estimated in the hippocampal formation.
Results
Signs of severe cognitive and motor impairments, mood disorders, and hepatotoxicity were observed in animals exposed to artificial daylight on ED20, unlike on ED14 and unlike groups exposed to natural daylight or conventional lighting. Activated microglia and astrocytes were observed in the entorhinal cortex, as well as dead and dying neurons. Neuronal counts revealed massive neuronal loss in the hippocampal formation.
Conclusions
These results suggest that long hour exposure to high illuminance visible electromagnetic radiations induced severe alterations in brain function and general health in mice partly mediated by damages to the neocortex-entorhinal cortex-hippocampus axis. These findings raise caution over long hour use of high illuminance artificial light.
Huong dan dat ve may bay gia re cac hang VIETNAM AIRLINES, JETSTAR, VIETJET AIR – VNTIC.VN
Ve may bay tu TPHCM - HA NOI - Đà Nẵng - Thanh Hóa - Huế - Đồng hới - Nha Trang - Chu Lai - Singapore - BangKok - Seoul
An overview of the Companies Act 2014 as it pertains to Irish registered limited companies, with the information and practical knowledge necessary to ensure that such companies comply with the Act.
Selamat berjumpa melalui majalah digital POTENTIA edisi ketigabelas, yang merupakan sarana komunikasi bagi kita semua untuk melakukan refleksi atas perjalanan karya kita sepanjang tahun 2016. Apakah kita semua telah mengisi kehidupan ini dengan sesuatu yang berkualitas dan berdampak bagi kehidupan sesama?
Tema “Sambut Era Baru” yang diusung pada edisi kali ini menandai berakhirnya tahapan pengembangan I peziarahan universitas ini (tahun 2011-2015) dan dimulainya tahapan pengembangan II (tahun 2016-2020) dari Rencana Induk Pengembangan (RIP) Universitas Katolik Widya Mandala Surabaya (UKWMS) tahun 2011-2025. Saatnya bagi institusi ini untuk ‘go to the next level and to the next landscape’ melalui pergantian jajaran kepemimpinan yang baru di semua jenjang. Pada akhir periode RIP, UKWMS diharapkan menjadi sebuah Perguruan Tinggi unggulan yang mampu menjadi mediasi transendental bagi sekelompok individu yang tersusun atas tubuh, jiwa, dan roh, untuk secara kolektif dapat melaksanakan transformasi sosial bagi masyarakat Indonesia.
Untuk mewujudkan mimpi tersebut, saya mengajak semua pihak bersikap pro-aktif. Cermati karakteristik dari masing-masing nilai keutamaan Universitas, PeKA: (1) Peduli: aktif ikut bagian dalam setiap kegiatan; (2) Komit: kesediaan untuk berbuat yang sejauh mungkin … “beyond the call of duty”; (3) Antusias: sikap amat bergairah, sangat berminat, dan bersemangat berapi-api dalam setiap tugas dan kegiatan, tidak ada rasa keterpaksaan, bahkan (serasa) selalu ingin melaksanakannya. Ekspresi lahiriah dari semuanya itu teramati pada torehan prestasi cemerlang dari dosen, tenaga kependidikan, mahasiswa, dan alumni yang berkarya dan studi di UKWMS, seperti diulas pada majalah ini. Hal ini semakin dipertegas dengan diraihnya Akreditasi Institusi Perguruan Tinggi dengan peringkat A dan tercatatnya UKWMS sebagai salah satu institusi yang termuat di dalam Buku Profil Peringkat 50 Besar Kekuatan Institusi Ilmiah Indonesia.
Bagi para pembaca di luar lingkungan Universitas, selamat mengecap dan menikmati suasana akademik yang kondusif di kampus kehidupan ini. Semoga dapat menginspirasi kehidupan anda sekalian untuk mau menjadi pribadi yang lebih baik sehingga kehidupan anda lebih berdampak positif bagi sesama.
Semoga kampus ini terasa semakin dekat dengan masyarakat dan selalu berada di hati masyarakat.
Tuhan Yang Maha Pengasih dan Maha Penyayang senantiasa memberkati kita semua.
Solid Car Rental Costa Rica rent a car costa ricaSolid Car Rental
Solid Car Rental Costa Rica esta preparada para hacer su experiencia de alquiler de coches tan simple, agradable y emocionante como sea posible, al mismo tiempo que proporciona el mejor valor en los servicios de alquiler de coches.
Fireside Chat with Sander Arts of Atmel: The Journey to Account-Based Marketi...G3 Communications
From the B2B Content2Conversion Conference, with:
Panelists:
-Chris Golec, CEO of Demandbase
-Sander Arts, VP, Corporate Marketing, Atmel
-Jen Gray, Director of Marketing, Extole
Graeme Osborne
Director, National Health IT Board
Peter Gow
Chair, National Information Clinical Leadership Group
Ernie Newman
Chair, NHITB Consumer Panel
Barry Vryenhoek
Chief Executive, healthAlliance New Zealand Ltd
(Thursday, 9.45, Keynote)
The InSiGHT-Human Variome Project Collaboration - Finlay MacraeHuman Variome Project
The International Society for Gastrointestinal Hereditary Tumours and the Human Variome Project have had a long and fruitful collaboration. Finlay Macrae, InSiGHT's Secretary spoke at the 4th Biennial Meeting of the Human Variome Project Consortium to update delegates on the progress of the collaboration and to share some of the methods that InSiGHT has used to build their organisation and their database.
Nw biotech fundamentals day 2 session 4 medical devices and diagnosticsNicholas Weston Lawyers
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• Definition of Medical devices and Diagnostics
• The stages of an R&D project
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Assembling the Norway Spruce Genome: 20Gb and many challenges, Umeå Plant Sci...Copenhagenomics
Dr. Douglas G. Scofield is Principal Research Engineer at Umeå Plant Science Centre at Umeå University in Sweden. Slides for his presentation: Assembling the Norway Spruce genome.
Uncovering the impacts of circumcision on the penis microbiome, Translational...Copenhagenomics
Dr. Lance Price, Director of Center for Food Microbiology and Environmental Health
Translational Genomics Research Institute (TGen) presents his talk: Uncovering the impacts of circumcision on the penis microbiome
The Art Pastor's Guide to Sabbath | Steve ThomasonSteve Thomason
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Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
This is a presentation by Dada Robert in a Your Skill Boost masterclass organised by the Excellence Foundation for South Sudan (EFSS) on Saturday, the 25th and Sunday, the 26th of May 2024.
He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
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Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
3. Proposal
• To implement routine whole genome sequencing in healthcare for a whole
society of 50,000 people
• To provide a cornerstone for optimal individualised health care with emphasis
on prevention as well as treatment, cost effectiveness and democratic
implementation
• To provide a foundation and resource for national and international research
• To develop a genomic healthcare model that has national and global
compatibility
• To perform a pilot study that explores the critical
scientific, technical, ethical, legal and social aspects
• To create an infrastructure for long-term management, maintenance and
evolution of the system
4.
5.
6.
7. Motivation
• Better Health Care
• Participating in solving global challenges
• Optimizing isolation, trust, smallness and
transparency
• Utilizing data richness
• Faroese genetic disorders: CTD and others
• Develope research competences and
knowledge in the Faroes
• Biotechnology cluster and job creation
• Being first
9. Initiation
• 1998: Initiative with Decode developed but
stopped
• 1998-2006: Internal discussions and
development of ethical framework
• 2005: Biobank Act passed in parliament
• 2006: Ílegusavnið/Genetic Biobank started
• 2007: First research project started
• 2008: Feasibility study of larger genomic
projects in the Faroes
• 2009-2012 Development of the FarGen
concept and initiation of the project
• Is a part of the Department of Research &
Development, Ministry of Health
10. The Biobank Act
§ 1. The purpose of this Act is:
1. to protect the rights of individuals in connection with Human Genetics
Research.
2. to establish the parameters for and to encourage research in the Faroe
Islands into human genetics so that such research may in the end:
a. advance competencies in the cure and prevention of disease;
b. advance competencies within the Faroese National Health Care System;
c. develop the research environment in the Faroe Islands.
• Diagnostics, therapy and treatment
11. Ílegusavnið/Genetic Biobank (GB)
• A coordinating Biobank and research unit in the Faroese Health Sector
• Mandated to develop and process applications for all research projects to
ensure they meet requirements of the Biobank Act
• Has custody of
• The Genealogy Registry
• Diagnosis Registries (various clinical sources)
• Collection of all clinical samples
• The GB is open for proposals for cooperation from any competent entity.
13. Healthcare databases with individual data
IHIS Pat-reg Pharmacy
Uniq_ID
Uniq_ID
In- and aoupatient
In- patient data
data 2009 - Uniq_ID
1994-2009-
Diagnoses(ICD10) Prescriptions 1994-
Diagnoses(ICD10)
Surgical ATC-kodes
Surgical
procedures(NCSP)
procedures(NCSP)
CPR
Uniq_ID
Date of Birth
Date of Death
CPR-number
Gender
Address
Name
Mortality- Cancer- Lab. tests
reg. reg.
Uniq_ID
Uniq_ID Uniq_ID In- and aoupatient
data 1984- From 1984 (1961) data 2004 –
ICD10 ICD03 Analysis
Results
14. Proposed Workflow
3. Store in Biobank for
- comparing to
genealogy, diagnosis and tissue
1.Blood sample or blood from
2. Whole genome sequence registries
biobank
- attach to the individual‘s
personal health record via the
Digital Health System (THS)
4. An individual has a medical
5. The clinician responsible for the
consultation. There is suspicion of
Genetic Biobank at the medical
6. The laboratory runs the test a genetically identifiable
center in the Main Hospital
condition. The GP/MD requests a
decides on the request.
test on the specific suspicion.
7. The GP/MD is informed of test 8. The patient receives the result.
9.Continued counseling from the
result, a decision on the level of And where necessary, follow up
genetic counseling team and/or
the genetic counseling needed from GP/MD, genetic counselor
relevant institution if needed as
and possible medical treatment of and/or relevant institution
well as possible treatment.
the patient (Nærverk, Gigni)
15. Implementation
• Public Health System
• Genetic Biobank
• Hospital
• THS infrastructure (Digital Health Record system, EPR)
• Other entities
• ELSI
• Political system
• Administrative system The Faroese Prime Minister
strongly supports the
• Relevant agencies and institutions initiative.
• Education – curricula and school material
• Buy-in from health care
• Buy-in from the people
16. FarGen Pilot Study
• Test sample of 100 individuals
• Implement prototype workflow
• Monitor scientific, technical, ethical and societal impact
• Education and public awareness
• Options to focus:
• Ongoing genetic studies including rare Mendelian conditions, cancers, specific Faroese diseases
• Healthy population: individual, family, familial disease association, imputation of genetic
information
• Impute 1000-5000 sequenced individuals to make a public health tool as a
goal.
• 1-2 year time frame for initial reporting
17. Ethical Issues
• Need for a democratic process
• Equality of genomics opportunity and uptake for all people
• Individual right to opt in or out – register of “non participants”
• The personal right to have your own genome interpreted privately
• Personal sequence should follow principle of “human right for best possible health care” (Treaty
of Human Rights)
• How to make a model with both local and global compatibility (maximise value)
• Responsible process empowering the individual – in a health and societal context i.e. in
cooperation with school system
• Informed consent
• Return of result - Feed back of actionable/non actionable information?
• The right to have your genome sequenced and combined with your health records – making it
usable
• Education of the people (population and professionals) and relevant institutions
18. Some aspects to consider in pilot study
• Should the pilot include minors?
• How will the individual right to data release be handled in the context of
family, population, pilot study?
• How will data be linked/integrated with THS(EPR)?
• Making the data usable
• Where will we store the data?
• Should individuals be told about actionable variations found in research made
in the FarGen database?
19. Ongoing Genetic Research Projects
• Four Eye diseases (Retinitis special focus on arrhythmias.
pigmentosa, Nanoftalmus, Albinismus oculi and • Parkinson
Bardet-Biedl syndrome) • Screening of 9th grade (14-15 year) for type 2
• Panic Anxiety (November 2007) diabetes risk
• Schizophrenia – (August 2008) ALSO: a range of epidemiological studies
• Psoriasis – is planned to start in Q2 2011 including: Crohn’s, ulcerative
• Autism (April 2008) colitis, indeterminate colitis, multiple
• Multiple Sclerosis (August 2008) sclerosis, thyroid disease, malignant
• Lethal Familial Syndrome (October 2008) haematological disorders, ovarian cancer
• GSD III
• Anosmia (March 2009)
• Psoreasis
• Idiopathic Generalised Epilepsy
• Carnitine transporter deficiency (CTD): health
status of heterozygous cases (population
frequency 1/400) in the Faroe Islands with
20. So......
• Practice today
• Ethical considerations
• Political and public engagement
• Cooperation
21. Acknowledgement
• Pál Weihe • David Bentley
• Sigurð Vang • James Lupski
• Tummas í Garði • Paul Flicek
• Guðrið Andorsdóttir • Gilean McVean
• Ulrike Steuerwald • Richard Gibbs
• Bjarni á Steig • John Belmont
• Hans Atli Dahl • Morris Foster
• Hannes Gislason • Stephen Turner
• Poul Gert Hansen • Lisa Brooks
• Oyvindur av Skarði • James Watson
• Ólavur Gregersen
• Jan Rasmussen
• Maria Skaalum Petersen
• Jónrit Halling
• Ann Østerø
• Jonhard Eysturskarð
• Fróði Joensen
22.
23. William Heinesen
”Far away in the mercury shimmering ocean there is
a lonely lead-coloured land. This tiny little rocky
land relates to the wide ocean as a grain of sand to
a ballroom floor, but viewed through a magnifying
glass this grain of sand is yet a complete world with
mountains, valleys, sounds and fjords, and houses
with little people.”