1) The document discusses the evidence and guidelines for use of radiation therapy (RT) in treatment of low-grade glioma. 2) Several practice-changing randomized controlled trials showed that for high-risk low-grade glioma, combining RT and chemotherapy improved outcomes over RT alone. 3) For anaplastic glioma, combining RT and chemotherapy improved survival compared to RT alone, especially for those with 1p/19q co-deletion. 4) Ongoing trials are exploring whether initial observation may be reasonable for some low-grade glioma patients after surgery, versus early adjuvant treatment.