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Low grade oligodendroglioma

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The document discusses current treatment options for low grade oligodendroglioma and the significance of 1p/19q loss of heterozygosity. It reviews evidence that surgical resection provides better outcomes than observation alone. Chemotherapy with procarbazine, lomustine, and vincristine or temozolomide is effective particularly for tumors with 1p/19q codeletion, while radiotherapy improves progression-free survival after incomplete resection but not overall survival. There is no consensus on the optimal treatment approach due to lack of prospective randomized controlled trials.

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EVIDENCE BASED SURGERY MEETING “ CURRENT TREND IN TREATMENT OF LOW GRADE OLIGODENDROGLIOMA ” Sanmugarajah Paramasvaran 12 th May 2011
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Clinical Question What are the current treatment option for low grade oligodendroglioma and significance of loss of hetrozygosity ?
Search Strategy P – pts with low grade oligodendroglioma I – excision C –observation / excision with radiotherapy and or chemotherapy O – prolonged survival / recurrence free period
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Medline Ovid Search
Scopus Search
Cochrane Search
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Defer treatment ,[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment of low grade oligodendroglioma without radiotherapy ,[object Object],[object Object],[object Object],[object Object]
Phase ll trial of Procarbazine,Lomustine, and Vincristine as Initial Therapy for patients with Low-Grade astrocytoma: Efficacy and Associations With Chromosomal Abnormalities ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Successful treatment of LG oligodendroglial tumours with a chemotherapy regimen of PCV ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Temozolamide as Initial Treatment for Adults With LGO or Oligoastrocytoma and Correlation With Chromosome 1p Deletion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Progressive low Grade oligodendroglioma response o TMZ and corelation between Genetic Profile and MGMT Protein expression ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
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REVIEW ARTICLE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
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Review Article Low Grade oligodendroglioma: Current trend and future hopes ,[object Object],[object Object],[object Object],[object Object],[object Object]
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Low grade oligodendroglioma

  • 1. EVIDENCE BASED SURGERY MEETING “ CURRENT TREND IN TREATMENT OF LOW GRADE OLIGODENDROGLIOMA ” Sanmugarajah Paramasvaran 12 th May 2011
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  • 4. Clinical Question What are the current treatment option for low grade oligodendroglioma and significance of loss of hetrozygosity ?
  • 5. Search Strategy P – pts with low grade oligodendroglioma I – excision C –observation / excision with radiotherapy and or chemotherapy O – prolonged survival / recurrence free period
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