The CONTROL trial investigated the efficacy and safety of recombinant activated factor VII (rFVIIa) in managing refractory traumatic hemorrhage. It was stopped early due to lower than expected mortality in the placebo group. There were no significant differences in 30-day mortality or morbidity between rFVIIa and placebo groups. Patients receiving rFVIIa required fewer red blood cell and total blood product transfusions within 48 hours. However, the study had limitations including an underpowered safety analysis and unclear adjustment for multiple comparisons. Overall, the study found no clear mortality benefit of rFVIIa for trauma patients.