This document describes integrated continuous extrusion and pelletization systems and fluid bed coating machines manufactured by Umang Pharmatech Pvt. Ltd. The systems can continuously produce drug pellets or granules of controlled shape and size from 400 microns to large sizes. The systems feature compact GMP-compliant designs with PLC controls. Throughputs for the different models range from 20 grams to 450 kilograms per hour or batch. Options include various extruder, spheronizer, and coating components to suit varied applications and throughput needs.

1. www.umangpharmatech.com
INTEGRATED CONTINUOUS EXTRUDER
AFully integrated continuous drug pelletization system including a Extruder (Axial, Cone, Dome, Radial, Die roller, Basket extruder,
etc.), with twin bucket weigh assembly and twin spherodizer for continuous pelletization, suitable for Large scale production of
pellets. This system fully integrates the extrusion and twin spheronization processes for converting drug formulations into free
flowing spheres of controlled shape and size of various sizes from 400 top large micron pellet sizes as desired .
STANDARD FEATURES :
Compact design GMP suites for continuous pellet production.
Fully integrated with Allen Bradley PLC controls 21 CFR certified.
Integrated plate lifting device for twin spheronizer plates.
Standard Cone extruder with feed hopper. (other extruders can be fitted as optional if desired by customer / product suitability.
Standard set-up 1mm, optional size of cone meshes (0.4 / 0.5 / 0.6 / 0.8 / 1.0 / 1.2mm).
Twin Drum diameter standard 500 / 700 / 900 mm depending on the size of extruder and throughput.
Recording of critical process data in software.
Report on Excel file can be exported to USB to view on computer.
System components easily accessible for cleaning and maintenance.
Spheronizer equipped with WIP system, i.e. wash in place nozzle and system.
Stainless steel 316 GMP design with high polish finish.
Variable speed for extruder (20-100 rpm), twin spheronizer (50-1500 rpm).
Twin bucket assembly with Load cell measurement for exact spheronization volume per batch.
Standard chequered plate : 3.2mm.
Controls by 12.1” IPC by a touch panel control with trends. (21 CFR part 11 certified).
OPTIONAL FEATURES :
THROUGHPUT / OUTPUT :
Model
Capacity
UICE - LAB
20 - 1000 gms/hr
UICE - 41 (Twin SPH-500)
30 - 50 kgs/hr
UICE - 101 (Twin SPH-700)
80 - 100 kgs/hr
UICE - 250 (Twin SPH-900)
250 - 300 kgs/hr
UICE - 20 (SPH-380)
5 - 15 kgs/hr
Radial extrusion machine with various mesh size (0.3 / 0.4 / 0.5 / 0.6 / 0.8 / 1.0 / 1.2 / special size) or other type of extruder desired.
Teflon coated drum, Various sizes of chequered plate (1mm / 2mm / 3.2mm / 6.5mm).
Continuous monitoring camera for spheronization process, measuring the roundness, size and sphericity of the spheres.
Jacketed / Insulated extrusion chamber and Spheronizer drums for temperature / heat sensitive applications.

2. SOLID DRUG LAYERING
FLUID BED COATER
Survey No. 146, H. No.1 (PT), Vasai Phata Highway Junction, Pelhar, Nh8, Vasai (E) - 401 208, Maharashtra (India).
Tel. : (+91-22) 30018900 / 30018915 - 98, Mob. : (+91) 982 012 0954, Fax : (+91-22) 30018908 / 30018913
E-mail : budhraja@umangpharmatech.com, Website : www.umangpharmatech.com / www.umangpharmaceuticals.com
Umang Pharmatech Pvt. Ltd.
Fluid Bed Coating is the new FAST COATING WURSTER range that builds on the proven Umang
technology and its benefits. The design of in-line removable nozzles, and continuous working air
purging filters makes it a unique bottom spray coating machine. This unique design of the
distribution plate and nozzles make it a ideal machine for fast and uniform coating application on
Mico pellets, Pellets, Granules &Tablets.
Drug layering is the new pelletization range that builds on the proven Umang technology and its
operational benefits. Similar design of loss in weight twin screw feeder, rotating plate and spray
gun for liquid ensures that process and validation scalability from a laboratory scale to a
production scale. This unique design of twin screw feeder, plate and spray nozzle makes the not
only a perfect drug layering machine but also an ideal machine suited for fast pelletization.
Powder loading from 10 - 600% is possible using this technique of pelletization. Our unique
sensors assure the product to be layered without touching the product during operation.
Minimum size of pellets which can be layered is 300 microns and above.
THROUGHPUT / OUTPUT :
Model
Capacity
USDL - 250
100 - 800 gms/batch
USDL - 380
2 - 3 kgs/batch
USDL - 700
20 - 30 kgs/batch
USDL - 1080
50 - 75 kgs/batch
STANDARD FEATURES :
www.umangpharmatech.com
THROUGHPUT / OUTPUT :
Model
Capacity
UFBM - 1
0.5-1 kgs/batch
UFBM - 3 / 5
2-5 kgs/batch
UFBM - 15 / 30
10 - 30 kgs/batch
STANDARD FEATURES :
USDL - 1300
100 - 150 kgs/batch
UFBM - 60
40 - 75 kgs/batch
UFBM - 120 (3 wurster)
120 - 250 kgs/batch
UFBM - 300 (5 wurster)
200 - 450 kgs/batch
Compact design suitable for GMP suites for continuous powder loading pelletization.
Perfect cGMP - design: smooth covering, No external tubing and piping allowing easy cleaning.
Through the wall installation: minimum space required in GMP area.
Cyclone assembly for capturing the dust and blower assembly for blowing air.
Stainless steel 316 GMP design with high polish mirror inside finish.
Fully integrated with Allen Bradley PLC controls and 12.1” IPC (21 CFR Part 11 certified).
Integrated plate lifting device for drug layering plates.
Variable speed for drug layering plate & Load cell based Twin screw feeder.
Two nozzles one for powder and other for liquid spraying.
High resistive meter for sensing automatic powder or liquid spray for automatic drug loading.
Liquid dosing peristaltic pump by speed & volume, load cell based controls.
Perfect cGMP - design: smooth covering, no external tubing and piping allowing easy cleaning.
Through the wall installation: minimum space required in GMP area.
FAST COATING (FS) distribution plate for wurster coating with in-process removable nozzles.
Continuous working filters with pneumatic air purging arrangement.
Flexibility (processes and products) for spheronization or pellet line / pelletization process.
Fully integrated with Allen Bradley PLC controls and 12.1” IPC (21 CFR Part 11 certified).
2 bar and optional 10 / 12 bar designs available.
Critical process data recording like temperature, airflow, humidity, pressure drop, etc.
Organic solvent processing with flame proof components available as optional supply.