The nurses' role in treating sepsis includes administering IV fluids and antibiotics, ensuring labs are ordered and results are reviewed, and monitoring the patient's condition to meet treatment goals within specified timeframes. Antibiotics should be given within 1 hour for non-ED patients and 3 hours for ED patients to reduce mortality risk. Broad-spectrum antibiotics are administered initially before narrowing treatment based on lab results. Sepsis claims over 1,400 lives daily worldwide so timely antibiotic administration is critical for patient outcomes and survival.