This document discusses chronobiology and fatigue disorders. It notes that chronobiology examines periodic biological rhythms related to light and lunar cycles. The most important rhythm is the circadian rhythm, which is a roughly 24-hour cycle regulated by circadian clocks in the hypothalamus. Fatigue disorders like chronic fatigue syndrome are debilitating and cause severe fatigue, pain, and other symptoms. The document suggests circadian rhythm disturbances may contribute to fatigue disorders, as seen in lower melatonin and cortisol levels in patients, which can impair sleep quality and increase pain/stiffness. Understanding circadian rhythms could help optimize treatment timing for fatigue disorder patients.