Chronic long term Diabetes mellitus may result in a disease of nervous system called diabetic neuropathy. Neuropathy is resulted due to increased blood glucose levels affecting the long nerves that carry sensory information to legs. The symptoms resulted include numbness, sensory loss, dysesthesia and night time pain. The burning, pricking sensation, achy or dull pain is experienced. Sensation like pricking with pins and needles is common. Loss sensation in legs or feet may lead to formation of ulcers and pathogenic infections. Due to this amputation of feet or leg may become necessary to stop the infection spreading theroughout the body. The autonomic nervous system innervates various visceral organs like heart, lungs, gastrointestinal system and urogenital system etc. Affect of diabetes on autonomic nervous system may result in autonomic dysfunction leading to orthostatic hypotension, or fainting when standing up. This may occur due to the failure of the heart and arteries to adjust heart rate and vascular tone appropriately and to keep continuous blood supply to brain. This condition is usually accompanied by a loss of respiratory sinus arrhythmia. Frequent diarrhea and vommitings, urinary incontinence and polyuria are other symptoms caused due to autonomic neuropathy caused by diabetes. Cranial neuropathy may affect various cranial nerves and may result in dysfunction of various organ systems. Vision problems are common due to affecting nerves related to vision. Solution Chronic long term Diabetes mellitus may result in a disease of nervous system called diabetic neuropathy. Neuropathy is resulted due to increased blood glucose levels affecting the long nerves that carry sensory information to legs. The symptoms resulted include numbness, sensory loss, dysesthesia and night time pain. The burning, pricking sensation, achy or dull pain is experienced. Sensation like pricking with pins and needles is common. Loss sensation in legs or feet may lead to formation of ulcers and pathogenic infections. Due to this amputation of feet or leg may become necessary to stop the infection spreading theroughout the body. The autonomic nervous system innervates various visceral organs like heart, lungs, gastrointestinal system and urogenital system etc. Affect of diabetes on autonomic nervous system may result in autonomic dysfunction leading to orthostatic hypotension, or fainting when standing up. This may occur due to the failure of the heart and arteries to adjust heart rate and vascular tone appropriately and to keep continuous blood supply to brain. This condition is usually accompanied by a loss of respiratory sinus arrhythmia. Frequent diarrhea and vommitings, urinary incontinence and polyuria are other symptoms caused due to autonomic neuropathy caused by diabetes. Cranial neuropathy may affect various cranial nerves and may result in dysfunction of various organ systems. Vision problems are common due to affecting nerves related to vision..