There are four types of chromosomes defined by the location of the centromere: 1) Metacentric chromosomes have a centromere located in the center, dividing the chromosome into two equal lengths. Human chromosomes 1 and 3 are metacentric. 2) Submetacentric chromosomes have a centromere slightly offset from the center, making the two sections asymmetrical in length. Human chromosomes 4 through 12 are submetacentric. 3) Acrocentric chromosomes have a severely offset centromere, resulting in one very long and one very short section. Human chromosomes 13, 15, 21 and 22 are acrocentric. 4) Telocentric chromosomes have the centromere located