This document outlines a conceptual framework for improving the HIV/AIDS response in chiefdoms in Zambia. It identifies several issues with the current inadequate and uncoordinated response at the chiefdom level, including a lack of leadership, duplication of efforts, and failure to influence cultural practices. It proposes strengthening the capacity of chiefdoms by establishing strategic plans, monitoring and evaluation systems, and coordinating bodies. The desirable outcomes include improved access to quality services, monitoring of service delivery, resource mobilization, and advocacy. The desired impacts are an improved quality of life for people living with HIV/AIDS, orphans and vulnerable children, and reduced new infections and AIDS-related deaths in each chiefdom.