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Chapter 5
Epidemiology
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
Epidemiology Is …
… the study of the distribution and determinants of health and
disease in human populations
(Harkness, 1995)
… the principal science of public health
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
2
Historical Perspective
Investigations of disease pattern in the community; comparing
people who had disease or who remained healthy
Person-Place-Time Model
Person: “Who” factors, such as demographic characteristics,
health, and disease status
Place: “Where” factors, such as geographic location, climate
and environmental conditions, political and social environment
Time: “When” factors, such as times of day, week, or month and
secular trends over months and year
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
3
Different Types of Epidemiology
Descriptive Epidemiology
Study of the amount and distribution of disease
Used by public health professionals
Identified patterns frequently indicate possible causes of disease
Analytic Epidemiology
Examine complex relationships among the many determinants of
disease
Investigation of the causes of disease, or etiology
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
4
Epidemiological Triangle
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
5
Figure 5-1
Agent of Disease
(Etiologic Factors)
Nutritive elements
Excesses, deficiencies
Chemical agents
Poisons, allergens
Physical agents
Ionizing radiation, mechanical
Infectious agents
Metazoa, protozoa, bacteria, fungi, rickettsia, viruses
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
6
Host Factors–Intrinsic Factors
(Susceptibility, or Response to Agent)
Genetic
Age
Sex
Ethnic group
Physiological state
Prior immunological experience
Active/, passive
Intercurrent or preexisting disease
Human behavior
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
7
Environmental Factors— Extrinsic Factors…
… influence existence of the agent, exposure, or susceptibility
to agent
Physical environment
Biological environment
Human populations, flora, fauna
Socioeconomic environment
Occupation, urbanization and economic development, disruption
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
8
Wheel Model of
Human-Environment Interaction
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
9
Figure 5-2
Redrawn from Mausner JS, Kramer S: Mausner and Bahn
epidemiology: an introductory text, ed 2, Philadelphia, 1985,
Saunders.
Web of Causation
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
10
Figure 5-3
From Friedman GD: Primer of epidemiology, ed 4, New York,
1994, McGraw-Hill.
Ecosocial Approach
Emphasize the role of evolving macro-level socioenvironmental
factors along with microbiological process in understanding
health and illness (Smith & Lincoln, 2011)
Challenges the more individually focused risk factor approach
to understanding disease origins
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
11
Calculation of Rates
Rates are arithmetic expressions that help practitioners consider
a count of an event relative to the size of the population from
which it is extracted
Number of health events in a specified period
Population in same area in same specified period
Proportion multiplied by a constant (k)
For example, the rate can be the number of cases of a disease
occurring for every 1000, 10,000 or 100,000 people in the
population
Can make meaningful comparisons
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
12
Morbidity Rates
Incidence rates
New cases or conditions
Attack rate
Number of new cases of those
exposed to the disease
Prevalence rates
All cases of a specific
disease or condition at
a given time
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
13
Prevalence Pot
The relationship between incidence
and prevalence
Figure 5-4
Redrawn from Morton RF, Hebel JR, McCarter RJ: A study
guide to epidemiology and biostatistics, ed 3, Gaithersburg,
MD, 1990, Aspen Publishers.
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
14
Morbidity Rates (Cont.)
Incidence Rate
Prevalence Rate
Number of existing cases
Total Population
_____
Number of new cases
_in given time period
Population at risk in
same time period
___75___
4000–250
× 1000
= 0.02
0.02 × 1,000 = 20 per 1000 per time period
250
4000
= 0.0625
0.0625 × 1000 = 62.5 per 1000
Mortality Rates
(routinely collected birth and death rates)
Other rates
Crude rates
Age-specific rates
Age-adjusted rates or standardization of rates
Proportionate mortality ratio (PMR)
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
15
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
16
Number of deaths in year
Total population size
_1720_
200,000
× 100,000
= 0.0086
Number of births in year
Total population size
_2900_
200,000
× 100,000
= 0.0145
Concept of Risk
Risk—probability of an adverse event
Risk factor
Refers to the specific exposure factor
Often external to the individual
Attributable risk
Estimate of the disease burden in a population
Relative risk ratio
Divide the incidence rate of disease in the exposed population
by the incidence rate of disease in the nonexposed population.
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
17
Use of Epidemiology
Disease prevention
Primary prevention
Health promotion and specific prevention
Secondary and tertiary prevention
Establishing causality
Screening
Surveillance
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
18
Use of Epidemiology (Cont.)
Health services
Used to describe the distribution of disease and its determinants
in populations
Study population health care delivery
Evaluate use of community health services
Nurses must apply findings in practice
Incorporate results into prevention programs for communities
and at-risk populations
Extend application into major health policy decisions
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
19
Community health nurses should exercise “social responsibility”
in applying epidemiological findings, but this will require the
active involvement of the consumer.
Community health nurses collaborating with community
members can combine epidemiological knowledge and
aggregate-level strategies to affect change on the broadest scale.
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
20
Epidemiological Methods
Descriptive epidemiology
Focuses on the amount and distribution of health and health
problems within a population
Analytic epidemiology
Investigates the causes of disease by determining why a disease
rate is lower in one population group than in another
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
21
Analytic Epidemiology
Observational studies
Descriptive purposes
Etiology of disease
No manipulation by investigator
Cross-sectional studies
Sometimes called prevalence or correlational studies
Examine relationships between potential causal factors and
disease at a specific time
Impossible to make causal inferences
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
22
Analytic Epidemiology (Cont.)
Retrospective studies
Compare individuals with a particular condition or disease with
those who do not have the disease
Data collection extends back in time
Prospective studies
Monitor a group of disease-free individuals to determine if and
when disease occurs
Cohort shares a common experience within a defined time
period
Monitors cohort for disease development
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
23
Analytic Epidemiology (Cont.)
Experimental design
Also called a Randomized Clinical Trial (RCT)
Subjects assigned to experimental or control group
Apply experimental methods to test treatment and prevention
strategies
Ethical considerations with human subject rights review
Also useful for investigating chronic disease prevention
Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
an imprint of Elsevier Inc.
24
Grading Rubric: Short Essay # 1
Women in other Countries
Your first essay will be highlighting women from other
countries. You will select one country outside the United States
and report how women are viewed, interesting information
regarding the culture, unknown facts about the country and its
lifestyle, and what types of health challenges women face
caring for themselves and their family. Your essay will be at
least 2 complete typed pages in your original thought. Please be
aware if your work is copied from another source, it is
considered plagiarism and you will receive a zero. Please
organize your paper to include a 12 font, double spaced format.
You will submit your paper in the Dropbox area (as a word
document) for grading and the Discussion Board (copy and
paste) for this assignment only.
Grading Criteria Maximum
Points
Describes the country selected and how women are generally
viewed 30
Describes 3 health challenges women face (illness, hospitals,
medical care) 30
Describe the impact the subject had on you (at least five
sentences) 20
Describes 2 unknown facts about the country and its people
10
No grammar or spelling errors, 3 references cited
10

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Chapter 5EpidemiologyCopyright © 2015, 2011, 2007, 2001, 199.docx

  • 1. Chapter 5 Epidemiology Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. Epidemiology Is … … the study of the distribution and determinants of health and disease in human populations (Harkness, 1995) … the principal science of public health Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 2 Historical Perspective Investigations of disease pattern in the community; comparing people who had disease or who remained healthy Person-Place-Time Model Person: “Who” factors, such as demographic characteristics, health, and disease status Place: “Where” factors, such as geographic location, climate and environmental conditions, political and social environment Time: “When” factors, such as times of day, week, or month and secular trends over months and year Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
  • 2. an imprint of Elsevier Inc. 3 Different Types of Epidemiology Descriptive Epidemiology Study of the amount and distribution of disease Used by public health professionals Identified patterns frequently indicate possible causes of disease Analytic Epidemiology Examine complex relationships among the many determinants of disease Investigation of the causes of disease, or etiology Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 4 Epidemiological Triangle Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 5 Figure 5-1 Agent of Disease (Etiologic Factors) Nutritive elements Excesses, deficiencies Chemical agents Poisons, allergens
  • 3. Physical agents Ionizing radiation, mechanical Infectious agents Metazoa, protozoa, bacteria, fungi, rickettsia, viruses Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 6 Host Factors–Intrinsic Factors (Susceptibility, or Response to Agent) Genetic Age Sex Ethnic group Physiological state Prior immunological experience Active/, passive Intercurrent or preexisting disease Human behavior Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 7 Environmental Factors— Extrinsic Factors… … influence existence of the agent, exposure, or susceptibility to agent
  • 4. Physical environment Biological environment Human populations, flora, fauna Socioeconomic environment Occupation, urbanization and economic development, disruption Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 8 Wheel Model of Human-Environment Interaction Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 9 Figure 5-2 Redrawn from Mausner JS, Kramer S: Mausner and Bahn epidemiology: an introductory text, ed 2, Philadelphia, 1985, Saunders. Web of Causation Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 10 Figure 5-3 From Friedman GD: Primer of epidemiology, ed 4, New York, 1994, McGraw-Hill.
  • 5. Ecosocial Approach Emphasize the role of evolving macro-level socioenvironmental factors along with microbiological process in understanding health and illness (Smith & Lincoln, 2011) Challenges the more individually focused risk factor approach to understanding disease origins Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 11 Calculation of Rates Rates are arithmetic expressions that help practitioners consider a count of an event relative to the size of the population from which it is extracted Number of health events in a specified period Population in same area in same specified period Proportion multiplied by a constant (k) For example, the rate can be the number of cases of a disease occurring for every 1000, 10,000 or 100,000 people in the population Can make meaningful comparisons Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 12 Morbidity Rates Incidence rates New cases or conditions Attack rate
  • 6. Number of new cases of those exposed to the disease Prevalence rates All cases of a specific disease or condition at a given time Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 13 Prevalence Pot The relationship between incidence and prevalence Figure 5-4 Redrawn from Morton RF, Hebel JR, McCarter RJ: A study guide to epidemiology and biostatistics, ed 3, Gaithersburg, MD, 1990, Aspen Publishers. Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 14 Morbidity Rates (Cont.) Incidence Rate
  • 7. Prevalence Rate Number of existing cases Total Population _____ Number of new cases _in given time period Population at risk in same time period ___75___ 4000–250 × 1000 = 0.02 0.02 × 1,000 = 20 per 1000 per time period 250 4000 = 0.0625 0.0625 × 1000 = 62.5 per 1000
  • 8. Mortality Rates (routinely collected birth and death rates) Other rates Crude rates Age-specific rates Age-adjusted rates or standardization of rates Proportionate mortality ratio (PMR) Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 15 Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 16 Number of deaths in year Total population size _1720_ 200,000 × 100,000 = 0.0086 Number of births in year Total population size _2900_ 200,000 × 100,000 = 0.0145
  • 9. Concept of Risk Risk—probability of an adverse event Risk factor Refers to the specific exposure factor Often external to the individual Attributable risk Estimate of the disease burden in a population Relative risk ratio Divide the incidence rate of disease in the exposed population by the incidence rate of disease in the nonexposed population. Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 17 Use of Epidemiology Disease prevention Primary prevention Health promotion and specific prevention Secondary and tertiary prevention Establishing causality Screening Surveillance Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 18 Use of Epidemiology (Cont.) Health services
  • 10. Used to describe the distribution of disease and its determinants in populations Study population health care delivery Evaluate use of community health services Nurses must apply findings in practice Incorporate results into prevention programs for communities and at-risk populations Extend application into major health policy decisions Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 19 Community health nurses should exercise “social responsibility” in applying epidemiological findings, but this will require the active involvement of the consumer. Community health nurses collaborating with community members can combine epidemiological knowledge and aggregate-level strategies to affect change on the broadest scale. Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 20 Epidemiological Methods Descriptive epidemiology Focuses on the amount and distribution of health and health problems within a population Analytic epidemiology Investigates the causes of disease by determining why a disease rate is lower in one population group than in another Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders,
  • 11. an imprint of Elsevier Inc. 21 Analytic Epidemiology Observational studies Descriptive purposes Etiology of disease No manipulation by investigator Cross-sectional studies Sometimes called prevalence or correlational studies Examine relationships between potential causal factors and disease at a specific time Impossible to make causal inferences Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 22 Analytic Epidemiology (Cont.) Retrospective studies Compare individuals with a particular condition or disease with those who do not have the disease Data collection extends back in time Prospective studies Monitor a group of disease-free individuals to determine if and when disease occurs Cohort shares a common experience within a defined time period Monitors cohort for disease development Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc.
  • 12. 23 Analytic Epidemiology (Cont.) Experimental design Also called a Randomized Clinical Trial (RCT) Subjects assigned to experimental or control group Apply experimental methods to test treatment and prevention strategies Ethical considerations with human subject rights review Also useful for investigating chronic disease prevention Copyright © 2015, 2011, 2007, 2001, 1997, 1993 by Saunders, an imprint of Elsevier Inc. 24 Grading Rubric: Short Essay # 1 Women in other Countries Your first essay will be highlighting women from other countries. You will select one country outside the United States and report how women are viewed, interesting information regarding the culture, unknown facts about the country and its lifestyle, and what types of health challenges women face caring for themselves and their family. Your essay will be at least 2 complete typed pages in your original thought. Please be aware if your work is copied from another source, it is considered plagiarism and you will receive a zero. Please organize your paper to include a 12 font, double spaced format. You will submit your paper in the Dropbox area (as a word document) for grading and the Discussion Board (copy and
  • 13. paste) for this assignment only. Grading Criteria Maximum Points Describes the country selected and how women are generally viewed 30 Describes 3 health challenges women face (illness, hospitals, medical care) 30 Describe the impact the subject had on you (at least five sentences) 20 Describes 2 unknown facts about the country and its people 10 No grammar or spelling errors, 3 references cited 10