The document discusses the challenges of uncertainty for doctors in general practice and family medicine. It defines uncertainty as being at the core of medicine due to a lack of complete information about patients' past, present, and future conditions. Doctors must cope with uncertainty in medical histories, diagnoses, potential outcomes, and impacts of interventions. How doctors and patients communicate and cope with uncertainty has implications for medical ethics, referrals, prescribing practices, and overuse of services. Uncertainty is an inevitable part of medicine that doctors and patients must learn to acknowledge and manage together.